Saturday, December 18, 2021

Motivation for me

 


Why is the USA so important to me? Is it being fucked and is there a way out of it? Why does India thrive? Can we predict the end of this journey? Does this matter at all to me?

The first three questions is about the USA. It is a relevant truth to me, dedicated to remaining modest citizen despite what I can achieve and ready to take risks, meaningful now since I believe in wish-death and the belief that I can partake in it. It is no longer academic.

So why did the USA fail? Why did India thrive? Why does China thrive? Understanding these issues delivers to non-actor me, meaningful prediction ability. If I understand markets that well, I will be a very rich man. I do believe that prices within a decade are best handled by chaos theory i.e. every soothsayer is a fraud. But a decade-wide or larger prediction is probabilistic and doable within the wide net of investment. That applies to both the political theory and the stock market. It is asymmetric prediction, winner prediction is slow, while losers are fast.

The hardest change in me comes from rising of India and China and the reducing strengthening of the USA. The link above blame rightly the effect of size on decision speed but that is only a visible effect, the rise of Asian giants (increasing centralization) and the weakening of the USA (increasing decentralization without effective coordination) is not caused by size but the politically correct speech by a technical specialist,  thus their weakening. Both Asians reaped the benefit of effective coordination by increasing centralization. I have believed for a long in decentralization which improves political correctness. It pails before centralization benefits, Modi wins, my feelings, because he listens to key bureaucrats as opposed to elected riff-raff. Xi gets effect for free. Both are personally uncorrupt, don't tolerate corruption, and have publically damaged lower corrupt.

One consequence in India has been the marginalization of Congress even in opposition. Better luck in HP and Uttarakhand with the solid tired-government sentiment. I predict the BJP government in UP and egg on the face of sir Akhilesh.

Modi juggernaut goes on to 2024 and likely another 5-years then. The replacement of centralization is replaced by both, chosen by effective coordination and anti-corruption transparency, even if privacy-incorrect! Political correctness is way too important and must never be abandoned even if operating in opposition. It is important to shut up political correctness sellers applying way excessive analysis to determine alleged incorrectness.

Friday, December 17, 2021

Spanish me culpa

 Medicina me culpa y Computación nueva medicina





 Me culpa significa que soy culpable. En pruebas empíricas, por lo tanto inexpugnables, el 20% de los diagnósticos de los médicos estadounidenses (los mejores en la tierra) dicen que prescribimos el medicamento equivocado, repetidamente, por lo tanto, un meta-imbécil en mi idioma. No es intencional, por lo que encontrar al culpable es una mala idea, pero las víctimas sufren y parte de la responsabilidad recae sobre los perpetradores.


Para mí, la razón es trivial para entender como científico de la computación, así como las soluciones: los pacientes tienen múltiples tipos, el enfoque de la medicina de talla única es estúpido, el mejor tipo de pacientes y luego lo hace como c ++, es decir, inventa el diagnóstico de clase o la medicina de precisión; o ir a mecanografía delegada o medicina personalizada. El médico estará mejor atendido si se enumeran los biomarcadores de diversas enfermedades y el medicamento, así como la frecuencia, el entorno (como el estómago vacío o lleno, etc.) y los efectos esperados, se derivan para los biomarcadores de cada enfermedad. Uno puede comenzar a escribir en C ++ (precisión) y pasar a personal. Es probable que la idea de diferentes fármacos para la misma enfermedad sea poco intuitiva y errónea, y es mejor expulsar a todos esos médicos si no se incluye la nueva información.


La FDA es estadounidense y los votantes allí pueden arreglar la medicina, pero yo vivo en la India con un rayo de esperanza más allá de la licencia raj, el sifarish y la victimización hindú (tanto que me llamé agnóstico, no hindú naastik) de una manera verdaderamente secular (menos tushtikaran ). Estoy orgulloso de estar a favor de la elevación a través de la reserva y los escaños políticos asignados, incluso una posición minoritaria en RSS durante mucho tiempo. La troika de Modi-Yogi-Ramdev llevará a India al siguiente nivel sin violencia. Y en Gadkari, Piyush y Sarma de Assam, etc., BJP tiene una profundidad más allá de la troika.


Hace poco se extinguieron una culpa y unos gustos muy grandes, presumiblemente capitalistas. El corredor de Kasi costó 332 millones de rupias, mejor utilizado para eliminar la desnutrición de los niños de la UP, dijo un idiota de Akhilesh. La respuesta contundente fue que si el corredor atraía solo a turistas, 3 millones de turistas que gastaban 1000 dólares cada uno, la inversión en Kashi generaría 3 mil millones por año. ¡La desnutrición durante muchos años en todo UP se solucionará para siempre con solo el 10% de impuestos! ¡Siempre que esos imitadores (supuestos) imbéciles nunca hayan estudiado con Sir Akhilesh!


Vendrán a los proyectos de Modi, pero es poco probable que vengan a los proyectos de Jinnah. Marque mis palabras para 4naths, Badri, Kedar, Gangotri y Yamnotri.


FSSAI es indio y debe incrementarse para aplicar estadísticas bayesianas, efectos cruzados aprobados por FSSAI y suplementos aprobados. No debería ser un reemplazo de la FDA, sino un complemento con ensayos igualmente respetados.


Vuelve a la medicina de precisión y personalizada. Es de esperar que los lectores comprendan la diferencia entre ellos, de ambos con la actual mm (Medicina Moderna), y su superioridad e inevitabilidad en el siglo XXI.

Medicine me culpa and Computing new medicine



 Me culpa means I am guilty. In empirical, hence unassailable tests, 20% of American Doctor diagnoses (best on earth) say that we prescribe the wrong medicine, repeatedly, hence a meta-moron in my language. It is not intentional, hence finding the guilty is ill-advised, yet the victims suffer and some responsibility lies on perpetrators.

The reason is trivial for me to understand as a computer scientist as is the solutions - patients are multi-typed, one size fits all approach to medicine is stupid, best type patients and then do as c++ i.e. invent class diagnosis or precision medicine; or go to delegate typing or personalized medicine. The doctor will be better served if biomarkers of various diseases are listed and the medicine, as well as frequency, environment ( like an empty stomach, or full, etc), and expected effects, are so derived for each disease biomarkers. One can start c++ typing (precision) and proceed to personal. The idea of different drugs to the same disease is likely to be unintuitive and wrong, and all such doctors are best expelled by non-inclusion is new mm

FDA is American and voters there can fix medicine, but I live in India with a gleam of hope beyond license raj, sifarish, and Hindu victimization (so much so I called myself agnostic, not naastik Hindu) in a truly secular fashion (minus tushtikaran). I am proud to be for upliftment through reservation and assigned political seats, even a minority position in RSS for long. The troika of Modi-Yogi-Ramdev will lift India to the next level without violence. And in Gadkari, Piyush, and Sarma of Assam, etc, BJP has depth beyond the troika. 

A very great, presumably capitalist guilt and likes were extinguished recently. Kasi corridor cost 332 crores, better used for removal of ill-nutrition of children of UP, said an Akhilesh moron. Telling reply was that if the corridor attracted just Tourists, 3 crore tourists who spent 1000 bucks each, the investment in Kashi will generate 3 billion per year. The malnutrition for many years in all of UP will be solved forever just by 10% taxes! Provided that copy-cat (alleged) morons never studied with Sir Akhilesh! 

They will come to Modi projects, unlikely to come in Jinnah projects. Mark my words for 4naths, Badri, Kedar, Gangotri, and Yamnotri. 

FSSAI is Indian and must be ramped up to apply Bayesian statistics, FSSAI-approved cross-effects, and approved supplements. It should not be a replacement of FDA but a complement with equally respected trials.

Return to precision and personalized medicine. Hopefully, readers understand the difference between them, of both with current mm (Modern Medicine), and their superiority and inevitability in century 21.

spanish morality



Thursday, December 16, 2021

On Morality of life-extension



 

Non-genetic negligible senescence-based Life-extension being proposed for life extension is new non-medicine-based technology that should and does drive doctors fearful and advised to be limited to medicine. This novelty is the discovery of DNA specialization by epigenetics and plasticity of every human, even Eutherian animals, age by epigenetic expression.

 

My method makes doctors irrelevant to age fixing by using liposomes for all products used, better than injections due to fixing of additional cell entry problems. By restricting To GRAS supplements, the need for Doctors is eliminated as is interference with off-aging drugs for normal illnesses. Opposition from doctors can and should be quelled for this special purpose

 

Since DSNA is not modified, every Hitler-like fears are baseless. Any modifications are to epigenome.

 

The reverse aging possibilities are a tremendous unexpected benefit of aging prevention research. It has a few amazing consequences.

 

1.    Idea of age-reset and thus wish-death. No one is required to live on, even a decrepitude life!

2.    Superior new medicines that not only cure beyond modern-medicine treatments but address cancers and aging,

 

I figure on 2 at least even if there is no proven aging reset. The point is that I do believe in plastic aging slows down which makes proven reset in extended years very useful. I consider cure possible but unproven at this point and my own risk under that of continued debilitation from chronic diseases and willingly undergo self-test by self-designed composition. I am 2 months into the 12-month test, my sugar levels have dropped below 120, have no episode of osteoarthritic pain, no need for nearly monthly isosorbide but no improvement in instability, which may require exercises in the gym, but feel better enough to try.

 

This is stupid once.

Elon Musk's Fears of Longevity

 

 

 

 

Tuesday, December 14, 2021

Repurpose drugs



There are existing applications of these ideas. The trick is to use them for different drugs and tests. Can be done by the state as well. Given the troika of Modi-yogi-Ramdev, India is no longer backward for reasons of entrepreneurship or corruption. For Covid-19, as example

https://hms.harvard.edu/news/repurposing-familiar-drug-covid-19

Dr. Arya repurpose-Algorithm by smart-search

1. For each FDA medicine, a table of proteins and genes impacted is made, where each entry gives the degree of effect.

2. The target disease is converted into the impacted proteins and genes.

3. The table is sorted by impacts. Partial impacts are ok, the result can be used to derive drug admixtures.

4. Top chemicals are further refined on basis of side-effects of an unwelcome kind.

5. Remaining chemicals are tested against human cells.

6. Safety of chemicals does not have to be done since repurpose. FDA1 and FDA3 can be elided. Let us call it the FSSAI test.

7. FDA tests can be pursued later at their pace.

Expect way cheaper and faster. Can and should be extended to supplements, which makes Indian FSSAI superior to FDA for two reasons - cross-dangers and supplements.

Dr. Arya repurpose-Algorithm by smart-parallel-test

Many pathology tests can be performed in parallel by using a quasi-test-tube, in which multiple test tubes are used at once, loaded by different samples in stoppered- test-tubes. Equipment like centrifuges can be purchased that work on quasi-tube. All elements can be loaded at once.

Strange repurpose of viagras:

 Fang, J., Zhang, P., Zhou, Y. et al. Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease. Nat Aging (2021). https://doi.org/10.1038/s43587-021-00138-z

  • Received

  • Accepted

  • Published

  • DOI[ medicalese ] https://doi.org/10.1038/s43587-021-00138-z[ English ] https://www.lifespan.io/news/viagra-identified-as-a-candidate-drug-for-alzheimers/?fbclid=IwAR3uXtJzG4bsR1byHCVoRpEIvvUpXSCrzeejT53D473PmYSU7Y26JNG6Ye8Dr. Sinclairc affordable cheek-swab DNAm aging-testshttps://www.reddit.com/r/longevity/comments/nkpjcm/by_early_2022_david_sinclair_plans_to_launch_an/

Sunday, December 5, 2021

Torn between India and the USA



Why torn between them?

None of the below are 7 ancient wonders, but they are Indian wonders. Can I repay the debt I feel, India for IIT, then second life, and the USA for a doctorate, post criminal TBI professorship, and ma social security?


I can try by gifting post-quantum NSA-proof encryption and signature system, undecidable by foreign powers. To both, I shall gift the world's best age-reduction system, likely so for a decade.

I hate some people in the USA but only a few, and these few have not done any violent act, so my retribution has to be within the law. But have convinced me it was not intended but circumstances of fears and economic hardship, that led to horrible life for 31 years for this TBI, who could not be cowed, now ending. There is no forgetting in my world view but the non-violent pursuit of justice in this life and beyond shall be done.

Do I have a prescription for others innocently wronged?

Yes, I do, close to Gandhiji. Retribution in kind, never initiate. Non-violent if inferior. Let unattached others return in kind. See me apply my prescription to myself. I have a Longevity protocol. Better than any FDA is self-application to myself and my family! I refuse to get old, or be a dead hero!

Retribution does not bother Nature. Many developments are dual-use. Applies easily to encryption. Harder but easy to see is aging reduction, considering my demise possibilities, why should any opponents escape justice or post-demise friendlies be justice-loving investigators?

What is the genesis of touted self/family applied aging protocol?

Take recommendations of the top 3 aging doctors; Dr. Sinclair. Gr. de Grey and Dr. Kennedy. Analyze them to suggested chemicals. Reduce them to the top few, ensure they are not-active, safe, and independent,  compose them for family, more for self. Comprehensive blood-test self/family after 1 month (me done, all okay), after 1 year, and also age-determination test after 1 year (I hope Sinclair swab done, many $300 otherwise).

Why in India and why torn?

Two top civilized countries in the world (at least while Modi/Yogi is in power). Both will benefit equally no matter where I am. India is better for now. Who knows when I become a dollar millionaire.