Yogi

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This is about an aging trial for Dr. Arya liposomal Aging, as developed between him, the medical school in Muzzafarnagar, UP, responsible for developing DNAm Age using Dr. Horvath's clock, Dr. Ramdev responsible for developing India based manufacturer of NMN, and Mr. Yogi, chief minister, UP for training the vast number of Liposome makers, for a very large number of technical entrepreneur capable of Liposome encapsulation of medical drugs.

It is based on the cutting edge development of drug delivery systems that will eliminate many requirements of injection, tablet, and capsules, dramatically improving medicine and sharply reducing cancers and auto-immune diseases like;y to be magnified with economic progress. It is a remarkable development of aging and health development in autonomous decentralized self-reliant growth for indigenous populations and service export markets. It requires a very sharp mind to recognize the opportunities to establish, using new technology, a win(patient), win (practitioner), and win (Liposome makers) situation by a government initiative.

What paradigms do you admit?

DDS or drug delivery system is very crucial in some cases for peak concentrations in blood, as reversing attacks on Linus Pauling and vitamin C indicate. Injections are not needed with liposomes administered sublingually. Any drug may cause cancer if history is smaller than 30 years unless a GRAS nutrient or vitamin or safety vouched by 30+ years history or a known safe plant chemical.

What are you doing regardless of other interests funded by yourself?

Doing 1.5 months of SASP reduction by Fisetin, Quertecin, and apigenin (all known safe plant products); and 0.7 months of adding to NAD+ using NMN (B3 form) and resveratrol (Nutrient) and NAD+ direct+resveratrol. K2/D3 (vitamin) for osteopenia. Followed by a DNAm test in the USA by blood, and another DNAm in October 2022.

If the medical school in Muzzafarnagar, UP, steps up?

Then DNAm test can be done in India. This facility can be used for a scientific measure of the usefulness of all age-related developments in India. Converse with Dr. Horvath.

If Ramdev is responsible for developing India based manufacturer of NMN?

I use NMN here and Ramdev+India gets a massive local and export market? Tested NMN adds enormously to Ramdev reputation as the first ayurvedic inventor of life-extension products.

If Mr. Yogi, chief minister, UP for training the vast number of Liposome makers?

A largely decentralized entrepreneur job stream for UP, also exported nationwide to replace bhayya eastern UP with the honored liposome makers of UP.

Cell and ortho-molecular medicine

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Orthomolecular medicine

Both are distinct and current-included forms of medicine. Cell medicine is inclusive of ortho-molecular medicine and limits itself to the use of vitamins and proteins all delivered by liposome, sublingual, powder drug delivery systems in order of sequence. Only certain patients are addressed, the rest are sent to modern medical practitioners. Ortho-molecular medicine is used (very high vitamin usage only in patients considered hopeless by at least 3 mm doctors}.

 

Use only drugs with 30+ year history, until life-threatened?

 

Current modern medicine has too many history-less chemical Drugs. The effects of many chemicals are not known long term, 30+ years later they may lead to cancer, and I refuse to believe in naysayers based on whatever theory. This is a practice followed only recently after a TBI level accident 31 years ago. I quit smoking and changed my life. I have many chronic diseases now, most from aging. I have drawn the inference from the last 60 years of my sir father, who passed away at age 88. All my uncles and aunts are dead, naturally dead with passing away ages of 70-80. My father lived 8 years longer than the best (top 88) and I attribute it to Yoga 30-60 minutes per day, starting at age 33 when he visited the USA, returning in 1960. I was a child then, and remember reading a book by Jack LaLane he brought back earlier. Jack lived to 95 and surprised everyone in his family. A rare American, who I never met, who brought a tear to my eyes. So did the passage of Shannon and Linus Pauling. The only ones who I am sure will live on, more than me, are Dr. Sinclair and saint Dr. Aubrey de Grey.

 

My philosophy on death?

 

Top are vitamins, Stevia, penicillin, metformin. What I say will be (or should be) criticized by drug companies and doctors, both groups that benefit from current FDA rules. Aging drugs are going to be wrongly hit but do not from life-threatening exceptions. I believe that once a person is dead, the civilized use of the body passes to the state, usable for lessons and organs. The rest can be stitched and restored back to whatever ceremonies need to be performed, restoration costs paid by the state.

 

Why liposome?

 

The rationale is economy of use limited to civilized use and conservative medicine while alive unless life-threatening. Drug companies and most have antagonistic interests in conservative medicine being proposed for reasons of unknown dangers. It extends to law because the USA does not recognize, as in the case of Stevia, the 1500-year use in Peru, and practices of Ayurveda, accepted by modern medicine. In many cases, the explanations and use guidelines are wrong but the compound and its safety can be measured. Bayesian clinical tests with safety profiles and benefits can be used to strengthening FDA without dangers. One cannot/should-not allow patents on many Ayurveda recommendations but clinical test passage by FDA has essentially the same effect!

 

The rationale behind the restriction on injection?

 

There is a particular reason for the inclusion of sublingual drug delivery systems, if injection methods are prohibited, then how does one do any urgent services? It is done by powder under the tongue in case of a possible heart attack! Such patients are best diagnosed by full-fledged doctors in emergency departments and sublingual methods in this case are just first aid. Of course, liposomal drugs are best taken by nose or tongue sublingual methods. In fact, many medicines in pill form work better in a sublingual manner. In fact, I suggest the method for all tasteless, even bad-tasting if pre-food is needed. One example is acarbose or Linagliptin diabetes medicine. Also, it makes sense to mask the evil taste by liposomal encapsulation. Injections are neither needed nor should be used unless absolutely needed.

 

Why use vitamins as in orthomolecular medicine?

 

In blood concentrations much larger than those achieved by powders, vitamin molecules have different effects than RDA levels. The post-utilization effects are usually nothing more than RDA level wastes, except a lot more of them. They are not toxic, except by concentration amount, and often testable in models. In many cases are not toxic and that can be pre-done on models. This is the case with others as well.

 

It is basic to any medicine, you will not further damage the patient. The last use of violation was in Nazi Germany. Strangest ways have to be employed by medical science to achieve this For Cell medicine, the goal is to try hugest concentrations of known safe (30-year use) chemicals, In “hail Mary” try to patients destined to die (3 doctors certify) when theoretically plausible, following success in models.

 

Which vitamins?

 

The B-vitamin has many forms with amazing consequences and unexplored consequences of large amounts. B3 for example leads to NR and NMN, both precursors of NAD+ and central to modern life sciences. C-vitamin in large concentrations is central to cancers control through greatly magnified oxidation effects. While the best blood concentration from six doses of 3gm each per day is 200 mg, even 100gm per day liposome per day is safe and uses researched now. D-vitamin is really a hormone that passes as a minor cure for scurvy but is central to calcium shepherding. Not understood are E-vitamin mega doses. It is known to go well with C. K1 is about closing wounds, while K2 is a required cohort of D3 for bones, osteoarthritis, and stones. Interestingly the role of mega-c and stones is controversial. Large concentrations and co-use may be helpful in age extension or decrement of the cause of deadly ailment.

Beyond medicine

Beyond medicine

 

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    Introduction to injectable liposomes. Liposomal forms of all pills and capsulation are the future, as it is the importance of drug delivery systems. There is a particular reason that I feel blessed to be in a state as progressive as no other on this planet than UP under Yogi, destined to be remembered like Ram rajay for the far-reaching updates to disease management of all chronic, cancers and aging. And like always, the administration helped behind the scenes, extending shared financial support and the enormous process of new liposome-formation jobs.

Cell Medicine contains orthomolecular medicine, as defined by me, will address issues of chronic aging diseases like diabetes, osteoarthritis, heart, and a lot more for which modern medicine has great treatments but no cure. It has no treatments or cures for cancers and aging. That I have them can be experimentally demonstrated after November 2021 in two months, time frame but no shift in goals. The point is the importance of delivery drug Systems, even better than injections is a liposome, available to all!

Why do you push D3 and k2 even on people without mild osteopenia like you?

D3 is a vitamin with mild RDA for defeating scurvy. It acts like a hormone in you. It is essential for depositing Calcium on bones well. It has many other tasks as well, like cleaning up blood vesicular path where calcium deposits and causes osteoarthritis with no cure in Allopathy, and stupid claims in other systems. Triaging evolution makes the Indian race demanding a huge amount of calcium and eating more has bad consequences of kidney stones and osteoarthritis! Calcium is widely needed but must be shepherded well. Triaging uses D3 for bones and thus needs k2 for vesicle and stone cleanup. Only Chinese and Japanese diets provide K2, from a nearly spoiled soybean diet! Even excess is not bad, most people need them, don't know they do, and suffer from incurable diseases later! A good bone scan if curious, 3000 Rs. or else eat some supplements. RDA tells you nothing about bone use. Way before excess damage, you become D3 intoxicated! You know it. K2 is best taken in MK-7 form. Based on my experience, even experienced dieticians do not know or appreciate K2 - why needed (Triage) and why as supplements (rotten soybean).

Why do you think you can add to the cancer fight?

Apart from liposome drugs like liposomes and Dr. Arya franchise on quick liposome incrementation, why do I think I can add to the fight against Cancer, comes from Linus Pauling and the research institute his legacy in Oregon, he is well known for lifelong advocacy of vitamin-c therapy. Even when alive he was hounded by mm practitioners who developed a huge number of clinical test results against him. 2 decades after death, researchers of his legacy showed him to be wrongly dismissed as an old man once great.

Middle of the 2010+ decade, the researchers discovered the huge difference between a pill and injection. It has to do with a peak concentration in blood. Even if 3 gm (max) drugs are quaffed six times a day, the peak never crosses 200 mg per mole. The peak with injections is 3000. Liposomes can achieve 15000. Doctors as a caste can be defeated. A liposome is even better than injection despite the delay in effect - it even avoids cell entry problems! It works for all pharmaceuticals, not food-grade powders.

How do you think aging will evolve?

Aging is simpler than cancers and the targeted chemical processes are quite small, doing DNA principally.

The importance of the drug delivery system will be recognized, medicine for all ailments will be injections, liposomes, or both. All aging drugs will be Liposomal first! Composite (meta-analysis clinical tests) will never be published that club pill, injection and liposome test in the same study and current or past such papers will be visibly withdrawn. The entire field will forcibly understand the mischief from ignoring the drug delivery system.

How do you think medicine will evolve?

Aging will soon be recognized as a disease, basic to healthspan everywhere. The technique of medicine will shift to cell extraction, fix in the lab, and restoration in organs for all diseased organs. Liposomal drugs will be used for prophylaxis. It will happen in at least my health span!

Dr. Sinclair has mentioned 3 exciting things?

1 working on blood-based Horovith age test, way cheaper than current Rs25000-35000 test, 2 needed for before and after.

2. Knowing if it helps fast within a month you feel the energy from NAD+ you made and SASP reduced by Fisetin

3 Continue testing MIB-626 in FDA2 after excellent FDA1 results. This improves on NMN+ Resveratrol, a better molecule for NAD+ and nitric oxide (I take L-ARGININE for it).

Drug delivery systerms

Drug delivery systems, beyond medicine

 

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A drug delivery system DDS is taught to all doctors but conscious unknown to 99% for whom it is an education waste and they only use 2, namely pill/capsule and injection.  For what follows, you must remember that no matter what the disease, the human body is a cellular construction and most medicines have to enter cells to have any effect.

Let us follow the sequence from a pill. After swallowing it enters the stomach where acid attacks it. Then if absorbed there or one of the intestines, it enters the bloodstream. there it proceeds to the liver and must be unattached by insulin. When the liver stop ends, it enters blood circulation. Now the targets may be simple cells. Or they are brain cells and medicine must penetrate BBB. Now medicine must enter the cell. If the target is DNA, then it must penetrate the nucleolus. Or it may have to penetrate mitochondria membrane-like CoQ10. If one assumes 10% success per try, one can see that .0001 or 0.00001% medicine is usefully delivered.

Doctors would be defeated nearly always. What saves them is injections. Drug goer directly to the cell. Far better results. Drugmakers know this. They formulate the drug inside their injections as liposomes. Now even cell entry is quick. Also, the liposome is soluble, hence in blood too. Hence get delivered everywhere without cell entry losses. The doctor does not know or care. the medical representative MR presents clinical trials where the injection defeats good drugs in efficacy. The brand wins.

Enter I, set to complement doctors and defeat them well using Liposomal undo aging drugs and my agents who will have shops or pharmaceutical desks and construct liposome encapsulation of whatever powder their doctor prescribed, such that encapsulation is 10-15 minutes. The encapsulated drug is far more efficacious.

Three DDS have been described: pill/capsule, injection and, liposome. A drug may use method4, dissolve under the tongue. It bypasses the stomach. or method5 which is how people snort cocaine. It too provides direct blood entry. There are others. Encapsulation in a liposome eaten does not require pharmaceutical grade and hence iv use of any liposome is a bad idea. But most liposomes enter the cells and hence the drug carried must be pharmaceutical grade.

Depending on the sizes of the liposome and properties of the drug, the liposome form is 4 to 100 times more potent. At least factor of 4 can be assumed For random memory NMN/NAD+ improve factor 4, Fisetin factor 50, k2/D2 factor 4. One can use these numbers to consider amounts needed. ! gm/day NMN from Dr. Sinclair is 250 mg liposome. The Fisetin improvement is enormous, in fact mayo protocol is not needed. Most Indians have poor osteoporosis and osteoarthritis control and 1 year of D3/K2 liposome will solve both issues.

I believe that my dosages are such that potent effects will  be seen by me wit5hin a month even as effects will be measured after one year If it helps me and my sister within a month, then I recommend to my wife and m0other, decision theirs. Recommend to world, as a practitioner in one year. Start October 12 at last with feel November 12. Know for sure October 2022.

Beyond medicine?

Cell medicine, as defined by me, will address issues of chronic aging diseases like diabetes, osteoarthritis, heart, and a lot more for which modern medicine has great treatments but no cure. It has no treatments or cures for cancers and aging. That I have them can be experimentally demonstrated after November 2021 in two months, time frame but no shift in goals. The point is the importance of delivery drug Systems, even better than injections is a liposome, available to all!

Why do you think you can add to the cancer fight?

Apart from liposome drugs like liposomes and Dr. Arya franchise on quick liposome incrementation, why do I think I can add to the fight against Cancer, comes from Linus Pauling and the research institute his legacy in Oregon, he is well known for lifelong advocacy of vitamin-c therapy. Even when alive he was hounded by mm practitioners who developed a huge number of clinical test results against him. 2 decades after death, researchers of his legacy showed him to be wrongly dismissed as an old man once great.

Middle of the 2010+ decade, the researchers discovered the huge difference between a pill and injection. It has to do with a peak concentration in blood. Even if 3 gm (max) drugs are quaffed six times a day, the peak never crosses 200 mg per mole. The peak with injections is 3000. Liposomes can achieve 15000. Doctors as a caste can be defeated. A liposome is even better than injection despite the delay in effect - it even avoids cell entry problems! It works for all pharmaceuticals, not food-grade powders.

How do you think medicine will evolve?

Aging will soon be recognized as a disease, basic to healthspan everywhere. The technique of medicine will shift to cell extraction, fix in the lab, and restoration in organs for all diseased organs. Liposomal drugs will be used for prophylaxis. It will happen in at least my health span!

Dr. Sinclair has mentioned 3 exciting things?

1 working on blood-based Horovith age test, way cheaper than current Rs25000-35000 test, 2 needed for before and after.

2. Knowing if it helps fast within a month you feel the energy from NAD+ you made and SASP reduced by Fisetin

3 Continue testing MIB-626 in FDA2 after excellent FDA1 results. This improves on NMN+ Resveratrol, a better molecule for NAD+ and nitric oxide (I take L-ARGININE for it).

Liposome Basis

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Why is it central to me?

What are they as doctors?

    Introduction to injectable liposomes

Diver elongation of telomere

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My comments are in italic.

 

It is worth examining this since it will have theoretically similar performance to HHP-HBOT and have lower cost as ordinary air can be used instead of oxygen expense. It matters not that the HHP-HBOT effort may be faster. A quick design of the simulation machine says that the costs are returns on the machine, attendant (rs 20000 per annum including benefits) and electricity, thus price of Rs10 per day of 2hr sessions can be achieved per 4 patients per day every 10 machines, attached to a hospital as shop. The attendant can run a shop filled by many machines, reducing the cost by that factor. Such machines will be useful for persistent diseases targeted for repeated treatment. These abstracts say that divers encounter HHP with ordinary air and a machine proposed have reasonable chance to work.

 

1.           Abstract

Many cross-sectional studies have tried to assess the in vivo effect of oxidative stress on organismal aging in general and on telomere length dynamics specifically. Here we followed telomere length dynamics over a 12-month interval, in divers exposed to intense hyperbaric oxygen in comparison with an age-matched control group. Both groups were exposed to extreme physical activity, as well. Among the divers following the oxidative stress, significant telomere elongation was observed in granulocytes and naïve T cells, but not in memory T cells and B cells. Telomere length in granulocytes was mildly elongated in the control group as well, a finding that may relate to the extreme physical activity to which they were exposed. While telomere elongation in naïve T cells may be attributed to telomerase activation, we suggest that in granulocytes the elongation results from undifferentiated hematopoietic cells carrying longer telomeres that repopulate the peripheral hematopoietic compartment. This event might be accompanied by enhanced cell division within the repopulating pool. Since the aging of mammalian tissues can be attributed in part to the reduction in the replicative potential of self renewing cells, enhanced cell turnover under conditions of hyperbaric oxidative stress might be directly relevant to tissue and organismal aging.

Research highlights

► Telomere elongation in granulocytes and naïve T cells in divers exposed to oxidative stress. ►No telomere elongation in memory T and B cells in divers exposed to oxidative stress. ►Telomere elongation in naïve T cells may be attributed to telomerase activation. ► Oxidative stress may lead to repopulation of the peripheral hematopoietic compartment.

 

2.          Abstract

Many cross-sectional studies have tried to assess the in vivo effect of oxidative stress on organismal aging in general and on telomere length dynamics specifically. Here we followed telomere length dynamics over a 12-month interval, in divers exposed to intense hyperbaric oxygen in comparison with an age-matched control group. Both groups were exposed to extreme physical activity, as well. Among the divers following the oxidative stress, significant telomere elongation was observed in granulocytes and naïve T cells, but not in memory T cells and B cells. Telomere length in granulocytes was mildly elongated in the control group as well, a finding that may relate to the extreme physical activity to which they were exposed. While telomere elongation in naïve T cells may be attributed to telomerase activation, we suggest that in granulocytes the elongation results from undifferentiated hematopoietic cells carrying longer telomeres that repopulate the peripheral hematopoietic compartment. This event might be accompanied by enhanced cell division within the repopulating pool. Since the aging of mammalian tissues can be attributed in part to the reduction in the replicative potential of self renewing cells, enhanced cell turnover under conditions of hyperbaric oxidative stress might be directly relevant to tissue and organismal aging.

Hibernation

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There is a reason why club 3 technologies together in that not only wish death is achieved, something new is made that removes the infinite boredom that may result. The two technologies beyond amrit for infinite life, within current physics and hence more than sci-fi (tech fi in my lingo) are, 

1. Wish death or amrit, must be first to utilize later technologies

2. Hibernation/Astivation to travel the solar system using realistic technologies

3. Brain download for light-speed travel without time elapse

#3 can be way down in the future with MIT technology to greatly expand the folded brain. It is #2 that requires research, continuing now, to perfect. We understand cold hibernation some. It became evolution engineered to allow animals to migrate towards the poles. The two poles are distant on the globe, hence the fauna that developed in the sea and on land are distinct. The north pole has polar bears and walruses for example. The south pole has penguins and eels for example. Evolution had to independently develop the mechanism for hibernation and tissue preservation on freezing.

The first overarching statement I make is that all cold hibernations examined so far, as well as extensions imaginable, will never be applicable to warm-blooded creatures like us. Stating this, I deny every sci-fi so far. The point is the regeneration of blood after freezing is not possible on thawing. Not only do I condemn sci-fi but all post-death cryopreservation which preserve with freezing.

Cryopreservation is not just sci-fi research, but immensely important in organ donation. It is estimated that only 20% of people get donations usefully while they wait in queues and die not only because of donor shortages but transportation losses. And here I claim that cryopreservation is not possible!

So is it the end? Not really because there exist warm-blooded animals that hibernate! The process has a different name - astivation. The best model is the Madagascar lemur! The evolutionary reason is the same - food sources in the predictable part of the year dry up. Only tolerated by animals that can genetically activate it! How does it work and who researches it?

In it, the body temperature drops, say 10fahr, the animal becomes lethargic, and heartbeat drops from the usual 180 to single digits. Unlike cold hibernation, the animal quickly recovers within a week, restores heart and breathing, and then rapidly drops to a torpor state again. Astivation itself lasts several months with a weekly brief waking up.

I think the wake-up episodes allow the body machine to be kept up, even while the lemur sleeps. I can imagine humans in the situation of multi-annual sleep with their bodies being woken up, and even monthly restore to expel wastes and restore hyper-nutrition food (lemur solves food issue by gorging when food is plentiful and storing energy as fat in their enlarging tail, thickens 40%, lemurs called fat-tailed in local lingo).

Who researches astivation?

video: Doing research on lemur

If you can afford it