elementary and full interventions

  Dr. Arya is a PH.D. and not MD (Medical doctor). None of what follows is Medical advice, or gives any company advice, despite using registered words in the reader's jurisdiction.

Elementary Interventions

EI is those that consider NAD+ sole determinant of Aging. It decrements from CD38 that opposes NAD+. CD38 increases with age as it is produced by SASP of senescent cells. CD38 is principal of SASP, senescents cleared when young by immune system, which declines by age. The immune may decline, senescent cells by definition ignore apoptosis, but can be cleared by senolytes of which fisetin was best in senolyte1.0 but grape seed extract is new best senolyte2.0. SASP names hundreds of chemicals depending on what senescent was prior to senescence. Senolytes clear only a few senescents.

EI then is NAD+ boost and CD38 inhibition. Recommend NMN for boost, helped by pterostilbene if non-liposome or resveratrol if liposome. NR can be used instead of NMN, even part-substitute okay. Half&half  bypasses business fight. Grape seed extract is recommended as senolyte.

Full Interventions

Beyond EI are other interventions based on my principles, generally applicable age 65 onwards. Starting this age, white cells produced by now inactive immune system begin to reduce to negligible populations by 80. Beyond,  the body is without significant defenses to opportunistic infections. NAD+ has declined, cd38 increases to death, unceasingly stengthless with no NAD+ and old weak skin and under with loss of hyaluronic acid.

EI gives some help, slows strength decline and limits some but not all kinds, of SASP generators. How does one measure bio-age and why do senescent cells arise? Cell turn into senescent ignoring apoptosis when there is a failure in protein selection to cure DNA breaks which keep happening from radiation  like sun, chemicals like bad parts of foods, etc. Cells lose their identity. Age randomness causes methylation of DNA between C and G sugars in DNA connected by phosphate, called CpG islands, the on/off switch is stuck. This is a random but synchronized process in trillions of body cells. This methylation is not just an indicator but true age determinant in that reversing the stickiness of it in many cells reduces age! CaAKG is a good recent cure. 

My style domination of Hallmarks of Aging suggests igf-1 improvement that effects mTOR badly. Dr. Fahi has controlled the major evil side-effect of diabetes by mixture of igf-1/DHEA which works in clinical tests. A good, better than Dr. Fahi, theoretically safe, intervention by me is igf-1/metformin/low-rapamycin.

SASP has many chemicals, and fisetin and Grape-seed-extract work on a few only. Qurtecin/apigenin is another combination. So are others. 30-50 cleanup is generally enough, raises NAD+ even without boosting it. Another point is that Fisetin is a flavonoid, and almost all combinations have senolytes properties! But the extra killed senescents is small. Sticking to Grape-seed-extract is sufficient. Another gain comes from cache administration from solubility in fat. Mice indicate 20 mg/kg, it is 1400 mg for me per fortnight or two days per month as in mayo protocol for fisetin (I take 350 mg liposome, 2 days each/month).

Another great senolyte is Spermidine. It also selectively improves cardio-aging. I will switch to spermidine/grape-seed half/half this October. By then I expect liposome spermidine to become a product.