The stupidest theory believed by 99% of humans is on Aging
is “that is how God or Nature wills it”. Aging is a disease, FDA disagrees,
their reason is that “no one has established provable (empirically visible)
improvements of the purported disease”. It leaves the field open to likes of Dr.
Gurante, enormously gifted faculty from MIT who was a faculty advisor to Dr.
Sinclair and Dr. Matt Kaeberlein at M
IT, has assembled a team of Nobel Laureates at Elysium, and
peddles an excellent but very mild improvement in aging, if at all, in my
opinion. They CAN avoid FDA since supplements are not drugs and they are
careful to avoid FTC! The war between NR and NMN has no federal referee!
Situation is Similar in India except that FSSAI seems to some control over mix of drugs like Vitamin and supplement claims.
Situation is Similar in India except that FSSAI seems to some control over mix of drugs like Vitamin and supplement claims.
My theory of aging is
proven to me by the observation that all cell based life ages and that cells
have have Hayflick limit of about 50 subdivisions before apoptosis. In fact I
consider the HL essential to life because the only cells with unlimited life
are cancer cells, avoided only by apoptosis! This is why I do not consider nmn
to be a final fix, just enough to extend the age to 150, longer life happening
by transfection, which allows some trees to live few thousand years even with
the HL since every cell division has a stem cell dividing too, and the stronger
cell survives. Telomere is a red herring!
Given my belief, have narrowed down to a
regimen, expect to be able to do it within a few months, see no urgency in
applying it. I expect world to be so by 2020. In fact, there is NO probability
advantage in following any particular life style. I expect (weak claims even now) of
improvements in heart disease and Alzheimer’s from nmn. There is nothing urgent
for self.
But wait. There are two reasons for speed. One I
visited USA and underwent 3 MRI and one MRA, why irrelevant. What was discovered was the start
of Parkinson. Confirmed on return to India. Poor doc here had no way to decode
the CD I got. Never mind, I will make 4 color prints next time. Nothing better
than excise and L-DOPA till the latter misses effectiveness due to progressive
doping. But there is a blog that analyses NR in Parkinson! To cut the long short, NAD boost helps PD! That is because NR can cross blood-brain barrier and salvage NAD+ helps with neuro-protective effects. NR has been tested to 1000 mg per kilo, so is human safe. It does show promise as it is effective against neurotoxins. This is common property of all forms of vitamin B3, including Niacin. Given the cost-differential I have started on Nicotinamide, non-flushing Niacin,- just overdose of water-soluble vitamin i.e. useless in worst case. Of course, NMN is planned, is better than NR, provided it can bypass brain barrier. It can very well following a vigilant search!
Two, it is not so for Dad. He, rightly, will not listen to my theories. His doctor’s do not oppose but say only that they expect no benefit or find human trial empirical evidence on internet (there is anecdotal and mouse based). So I will begin soon on self, hopefully this self-test will either cure me of pretensions of philosophical/chemistry aggregation of dependable researches, or push him into doing it. MY full regimen is significant exercise + metformin + nmn + Mitoq. I expect significant exercise + metformin + nmn + coQ10
Two, it is not so for Dad. He, rightly, will not listen to my theories. His doctor’s do not oppose but say only that they expect no benefit or find human trial empirical evidence on internet (there is anecdotal and mouse based). So I will begin soon on self, hopefully this self-test will either cure me of pretensions of philosophical/chemistry aggregation of dependable researches, or push him into doing it. MY full regimen is significant exercise + metformin + nmn + Mitoq. I expect significant exercise + metformin + nmn + coQ10
within a month, anecdotal self-proof within 4
months and business plan for metformin +
nmn + Mitoq within 7 month (in 4 sublingual pill supplement per day). Only
diversion is self-pursuit of ECP and HOT first, by then!
By then my doors will be ready for in-house 2
month plans for ECP (To date, more than 300 studies have been published showing the benefits of ECP therapy) and Hyperbaric-oxygen-therapy (HOT) (Popuaar with aged Movie stars but also bad wounds, sports, TBI etc) along with
supplementation! I do no drugs, hence immune to IMA and only claim improvements
to Aging, not a disease even in India! If positive effects are reached by
willing friends and relatives first few years, that is good enough. If all
works according to plan, I have captive facility of High-quality life-extension for family for repeats every
3-5 years for life for under a crore!
What is cell transplantation?
Parkinson’s is a progressive neurodegenerative condition.
This means that cells in the brain are slowly being lost over time.
What makes Parkinson’s particularly interesting is that certain types of brain cells are more affected than others. The classic example of this is the dopamine neurons in an area of the brain called the substantia nigra, which resides in the midbrain.
The number of dark pigmented dopamine cells in the substantia nigra are reduced in the Parkinson’s brain (right). Source: Adapted from Memorangapp
Approximately 50% of the dopamine neurons in the midbrain (not me with very early analysis) have been lost by the time a person is diagnosed with Parkinson’s (note the lack of dark colouration in the substantia nigra of the Parkinsonian brain in the image above), and as the condition progresses the motor features – associated with the loss of dopamine neurons – gradually get worse. This is why dopamine replacement treatments (like L-dopa) are used for controlling the motor symptoms of Parkinson’s.
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