Robust
Life Extension has CSM (commonsense semantics) not discussed here. Both
violate EBM (evidence based medicine), my epistemology, but are still discussed
here. My belief is in EBM proof (CDA does), except when deviating for explicit
zed discussable reason, like this, by all EBM believers, extrapolating from known
science. Tomes, respected opinions, experience etc. are ignored.
My simplified Model break cellular energy Krebs cycle into
three sub cycles – citric acid, ADP-ATP, and NAD+-NADH. ADP-ATP is catalyzed by
a coenzyme which is assisted by Q10. Hence exists the coQ10 with known
non-toxicity. NAD+ also declines with
age. There is no way to directly increase NADH known. NAD+ increment is the
game. If not incremented directly, then do by precursors. There are many
including NR, NAM, NAN, NMN etc. One
expensive way is Chromadex monopoly NR. Another way, mildly less
expensive is NMN. Chromadex NP averages $1.5-$3.0 per day for 250-500 mg.
NMN route is $0.87 for 479 mg/day. It is good to have competition. Of course company{alivebynature}
implies but avoids stating superiority over NR. NMN is available starting
middle October 2017.
My theory is availability for sane experimentation by
extrapolation, strong belief in cutting edge supplementation for father, accept
only EBM or experiments are sane if sane
researchers have started human tests.
This is the sales-write-up
(like a paper hence at least respectful) I want readers to comment on. Looks
safe to try, (recommended by Sinclaire, MIT-PhD, HARVARD-MD/discovered
SIRT-1/Reservetrol/sold for 750M$/Can’t be hungry). Also it is said to have
anti-diabetes side-effects.
Not recommended or
disapproved by FDA. But at worst: a waste of money; at best: robust life
extension towards singularity; neutral: expensive anti-diabetic. Note that anti-oxidants
reduce the anti-aging properties of metformin in worms due to mitohormosis.
But
The administration of metformin (MET),
glibenclamide (GLI), and repaglinide (REP) exhibited significant reduction in
the malondialdehyde (MDA) concentration and considerable improvement in the
altered activities of antioxidant enzymes. This
establishes the fact that they provide additional antioxidant protection as
antidiabetic drugs, thereby protecting the
pancreas from oxidative stress-induced damage during diabetic complications.
Moral is when top-level doctors
disagree, it may make sense to shoot blindly if safe!
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