Comed Management: both CoQ10 & Niagen

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To summarize extensive research, there are 4 aaqgs-aging assists towards 1st singularity - ECP, Niagen, CoQ10 and metformin, that each have credible scientific support, ongoing studies, but no conclusive proof. aaqgs-aging requires life-extension and/or robust life - either your age is extended significantly, failing which QoL (quality of life) is improved significantly, or both. ECP and CoQ10 have QoL proof and age-extension mm reputation, Niagen and Metformin have age-extension belief and rationally backed seller reputation. Metmorphin also improves QoL by fighting cancers through densification of cells.

The figure above is remarkable in that it simplifies my thinking, predicts my sister experiences, explains why chromadex advice is unsound etc., beyond why it works at all. Point is the central double box marked NAD+ and ATP depletion. These are 2/3 (citric Acid unimportant any way) premier energy cycles in cell chemistry with these depleted ALWAYS on aging. CoQ10 addresses ATP_ADP cycle. Nicotanamide riboside addresses NAD+_NADH cycle. It is silly to focus on just one! You feel enervation from just Niagen, as my sister reported. Prior to this, she was just on CoQ10 or Niagen! MY comed recommendation is BOTH, will start self-test as soon as Niagen arrives. Strictly by theory, to be empirically tested, 200 mg CoQ10 (trikatu, triphala contraindicated byDiabetes) and 250 mg Niagen at night (after another test).

A proven dangerous QoL improvement (requires MD) for (some) males is to be injected with testosterone 2-6 weeks. Works for many Steroid class drugs but dangerous.

To understand this figure, apoptotisis (programmed death) and necrosis (injury death) are two ways cells die. Programmed death is e.g. how digits are formed in womb - cells send messages to intervening cells to die! Unfortunately, after DNA damage, cells may die in old age for no good reason. Cell death is why damage is cumulative!

The other self-test is economics based. 250 mg Niagen raises NAD+ within 24 hours, 500 mg even more.

1.       If you do nothing, it rapidly falls to 0 and stays there.

2.       If you switch to maintenance dose as recommended, the NAD+ stabilizes to some quantity driven by dose – 250-500 mg optimally.

3.       My experiment with self, based on feeling energetic – switch to 10% cost Niacin till next Niagen boost. Both Niagen andNiacin are no flushing B3. Niacin raise of NAD+ concentration is glacial – hence need Niagen. BUT no one has thought of Niacin as maintenance dose! Idea is avoid costly Niagen for very long! So quaff 500 mg Niacin, be on niacin for 1,2,4,8,0 days before next Niagen 500 and see how it works! Theory suggests that BOTH plus Niacin maintenance should work better than 400 mg per day CoQ10 now. If not, rid Niagen! CoQ10 works!

All this effort makes sense as tree-like singularity gathers steam!