Dr. Arun Kumar Arya and Manaswini Mittal
It is possible to advance medicine, awaiting tough
scientific tests to establish by strict empiricism, certain plausible
hypothesis that are good enough to be used as established science while the
tougher empirical tests are carried out in required time. For this to happen,
very conservative analysis of risks are done such that no known even plausible contraindications
are signaled, safety is established in mice and humans, stay within 10% of first injurious dose by
weight in test animals. Separate analysis is done on component basic for mixed side-effects and pregnant or newly milking people are NEVER allowed!
This is to admit nutraceuticals on a rational basis when
they are hard to analyze based on hard-science alone, either because the
measurement of the goal variable is not conclusive (what does age extension measurement mean) or the tests would take too
long and be useless to the beneficiaries. Their safety is a plain rational hypothesis, awaiting conclusive scientific studies.
Latter is quite common in modern medicine when the patient has no more effective modern medicine available and the consulting physician allows ridiculous treatments. If nothing else, they provide relief to the patient p and loved ones of p who all believe that something is being done! In most cases, money is spent foolishly with little hope, even on irrational cures!
Latter is quite common in modern medicine when the patient has no more effective modern medicine available and the consulting physician allows ridiculous treatments. If nothing else, they provide relief to the patient p and loved ones of p who all believe that something is being done! In most cases, money is spent foolishly with little hope, even on irrational cures!
Absent conclusive results for or against, without evidence based statistical certainty, what counts most is the opinion weight for products and opinion weight against the person making the recommendation. Ad hominem
attacks make sense! However incomplete information produces very evil results
and both sides to such attacks must be given equal space. Note that conclusive
empirical tests for and against are assumed missing. A rational patient
management system can be defined over nutraceuticals and over-the-counter
medicine that is patient centric rather than current seller-centric systems. In
fact, even more rigorous tests can be conducted through customer responses and
reported experiences to testable hypotheses despite the paucity of hard
evidence. I call them rational hypothesis in between anecdotal and evidence
based anything.
Evey deviation from current orthodoxy into
Aaquantum-rational hypothesis requires very clear epistemology i.e. of what is
considered evidence and conditions when the current evidence based orthodoxy is
to be avoided. For Aaquantum-rationality, the following summarizes my extensive
experience-
1.
Even lower ranked doctors of modern-medicine
(henceforth mm) licensed by law; are always superior to any alternative system
for every episode.
2. Mm systems are not not necessarily ideal forchronic diseases.
2. Mm systems are not not necessarily ideal forchronic diseases.
3.
These including diabetes, heart disease,
Parkinson etc. Most important, missin g from list so far, is aging, which is also
considered a disease, not a natural condition.
4.
Our work is hence limited to essential treatmnts
that do not normally lead to contra-indicated behavior and leads to the proven
goal of robust life extension.
After arduous research over many
years, one of the authors has concluded that only 4 items at this point
relevant to the disease of aging. There is nothing positive that can be done
beyond instructions of normal doctor for heart disease and stroke. Nothing
short of densification of cells and extending life time of cell division by
transfection will work against cancers. There are 4 things possible but diet
for agig, I am a convert, not just a preacher, have positive anecdotal stories
affirming, there is plenty of non-conclusive evidence, conclusive studies are
in progress, there is no point in waiting for better degree of evidence.
1.
Cell processes have three important energy
cycles ADp-ATP, NADH-NAD+ and citric acid, Last is not major any way. First
cycle can be improved by CoQ10. Middle by Niagen.
2.
General circulation, even heart occlusions can
be improved with ECP (external counter pulsation)which effectively wraps a
flexible elastic membrane on the legs that is pneumatically pumped in the quiet period of the heart, while he
patient is lying comfortably. This is done for 1 hour every day for 2 months.
3.
The diabetic medicine metformin effects pathways
there other than the prescribed sugar-control pathway and leads to
densification of cells. Comparative studies from NIH database over 12 years
have shown that mild diabetic live 5 years longer than equivalent non-diabetics
who in urn outlive the insulin treated patents by 5 years. Moment you believe
this data
a.
Why can’t metformin be eaten by people suffering
from aging disease
b.
If you are already diabetic, all insulin based
interventions are counterproductive up to the highest prescribed concentration
of 2.5 gm per day
c.
Despite ancient orthodoxy, most up to-date
literature pooh-poohs the lactosis fear and recommends metformin with
kidney-disease patients.
In the medium term,
within my lifetime, turbine pumps will be ready and perfected for the heart.
Transfection with stem metamorphosis of skin cells will advance to the point of
densification and error free division.
Extra metmorhin has not hurt me any way, benefits are
theoretically there. CoQ10 has breathed life into gym exercises – I do not
escape exercises on the grounds internal to me of feeling tired. The following
2 tricks have been tried successfully on myself and is the hajor theme of this
note – theoretically plausible mixtures of east (Ayurveda) and west (niagen,
coQ10 and metmorfin).
Theoretical justification
There are two kinds of statistics – the popular one for over
80 years and the Bayesian statistics. The fundamental difference is on testing
– the popular version eliminates past experiences and deals only with the
history in the test. The Bayesian model deals with increase or decrease of the
probabilities established from past practices in light of the test. One can
view Ayurveda as providing historical probabilities. Unless contra-indicated
(ALL bhasams), it is wasteful to deny ALL of the past!
Many antioxidants (curcumin etc) and antiseptics (Neem)
await discovery by west. Even better is careful analysis of east and medicines
of the west. As per simple rules, two enhancers of digestion with mild taste
and no very-careful contra-indications exist that help any Ayurvedic medicine.
These are triphala and trikuta. Triphala, being fruit product is contraindicated
to one author. However trikuta can be used and is being used with CoQ10, Niagen
and metformin. IOt is very unlikely that any of the three ingredients interact
with any west medicine.
Supporting weakly is the fact that CoQ10 with bioperine (patented)
is available and gets favorable reviews. What is bioperine but highly effective
form of tikuta! One can consider small amounts of greatly effective bioperine
with larger amount of less-effective, but still cheaper trikuta, applicable
with all medicine that do. A sane add in Bayesian statistics!
2. Second test tried on self by raw feelings alone is to
take double dose of Niasin and alternate that with much cheaper Niacinamide,
both being B3. The raise in NAD+ by niacinamide is glacial, not so for riboside,
hence a market for it. At 250 mg, the dose is half of recommended 250-500.The
rise in nad+ iks very quick – few hours after the first dose. While no good for
NAD+ raise, anecdotally, it does seem to keep the levels high!
3. There is another weak evidence for trikatu. Our theory
has identified here barriers any medication must cross. Through each barrier,
only a fraction can go through. These are stomach-blood barrier, cell-blood
barrier and cell-fluid-mitochondria barrier. The are two ways to breach the
stomach-blood barrier –
1. Trikatu/triphala improvement in absorption
2. Direct IV into blood
It turns out Glutathione is effective largely through IV
route. Reservetrol and PQQ etc are too delicate, good only for fresh ingestion by IV route! All greatly
increases the cost and motivation. Mitoq is a very effective form of CoQ10
which beaches all the walls! Hence partial breach of 1 wall is useful.
Conclusion
Trikuta mediated coq10, niagen and metformin were discussed.
There is strong anecdotal evidence and theoretical justification. Time to test
the hypothesis on a group scientifically.
