Dr. Arun Arya's Hyperfunction Aging Theory
Disclaimers: I am not a medical doctor, but a 20-year deep dive in biology and biochemistry, nor is Dr. Sinclair (NMN, Sirtuins) or Dr. Kennedy (Ca-AKG). I consider myself very smart based on the amazing scientific way they were discovered despite the deafening commercial din. The best way to benefit is to formulate a plan and discuss it with your doctor MD. Even I do it.
First, some intuitive facts that must be satisfied by any aging theory. Mine does and it is hard to even imagine any other compliant aging theory.
1. (Fact) No child is born old. Counter-free: Even in extreme populations crucial to valid theories, even in diseased extremes, there are no credible samples. Somehow the joint statistical DNA average age is reset to zero independent of the age of both parents.
2. (Fact) A child seems to be indistinguishably born from women under menopause and males to 75. Somehow, the parent's DNA is preserved during the entire parent's life.
From just these, one believable theory is the “Information theory of Aging” by Dr. Sinclair which says that DNA is preserved in life, and there is an epigenetic layer on top of it, perfect at birth, but degraded in life, simulating aging. He is the only bio-chemist known whose aging theory is consistent with these observations.
3. (Fact) All scientists must be assumed guilty unless proven innocent, particularly when dealing with the economics of their expertise. The only way to become truly believable is to use the recommendations on themselves and show credible gains. Every scientist suffers from aging! Dr. Sinclair does. So do I. It is stupid to believe that he or I are special, not random.
There are two empirical facts independent of whatever religion you believe. These are i) you and all biological life, including plants, on earth are made of 1 to many trillions of cells that even look wrong on seemingly independent things like skin, bones, nails, hair, etc. ii) all life is a consequence of evolution, essential to understanding de-aging. [My belief in evolution is from my derivation of de-aging from it.]
4. (Fact) A cell is a list of cellular material and 1+ sacs of many kinds, particularly DNA, mitochondria, ribosomes, etc. DNA is a large double helix molecule that is geometrically wound tight with only some parts unwound, enabling the same sub-molecule to become one of many as reactions only happen at exposed parts. The ends are called telomere which shorten on every division. Ultimately, they shorten the DNA so much (after 50 - 60 divisions) that the cell does not divide anymore, every division happens (1-2) years. Each mitochondrion has its own DNA and each runs the Krebs cycle, in particular the ADP-ATP sub cycle which is for energy. Both mt-DNA and telomere are related to non-DNA aging. The biochemical miracle is evolution discovered perfect copying and shutting reproduction during division by total tightening of the entire molecule. This total exclusion is a mark of terrestrial life and may not have been discovered by any other evolution on another planet of our universe.
5. (Fact) While all cells depend on the organ they belong to, every cell has identical DNA, folded differently to expose different behavior, but all allow total tightening to prevent copying while error correction proteins are made active. That is unreal behavior to all biological molecules in which copying for propagation is fundamental, all DNA cells can and do no error fix while spawning. This allows evolution to happen, prevents errors, and is true for all DNA in all animals, microbial life, plants, and trees. Ultimately every DNA in every cell is the same and OSKM chemicals can convert any cell to its pluripotent form. Recently extinct animals can be revived but not dinosaurs.
A hyperfunction takes many parameters and returns many results. Assume that the complete status of the body is parameters. The aging hyperfunction returns a new value of all parameters and several diagnostic values being the overview along various aging dimensions and a Boolean (alive | dead) or integer that also states death state of heart-dead, brain-dead, <organ>dead, <ALCOR>dead, etc.
Body death is the earliest death in any dimension from the many dimensions eroding in parallel. My aging theory contains Professor Sinclair's theory of “information aging” as a small but vital part and is renamed “DNA sub-theory”. A full list derived by me, based on human anatomy and processes is
1. DNA sub-theory: It has 4 components of Sirtuins, AMPk, mTOR, and Igf-1, one way to focus on these is MIT doctorate with empirical studies, and another is mine using the greatest 2013 research paper on “Hallmarks of Aging”, computing graph dominators of its graph, getting these four and convincing myself that Dr. Sinclair is the only one focusing on these. He became my virtual professor like Eklavya and archery in Mahabharata. mTOR alone increases aging, almost all comforts of technological evolution substantially boost mTOR while the other 4 improve aging, somewhat each. NAD+ boost can be done through NMN (best) or NR, best for overall aging. There are supplements good for aging in Ayurveda like ashwagandha and Brahmi, 10-100 times cheaper than counterpart chemical medicine. At the organ level, Bones and reduction of osteoarthritis are Calcium, vitamin D3, and K2. D3 helps calcium deposit on bone, k2 prevents it from depositing in arteries and is a miracle superfood unjustly ignored. Pterostilbene is a useful anti-oxidant even better than resveratrol, either required as an anti-oxidant for an aged missing immune system.
