Thursday, November 29, 2018

Capturing entire Agnostic evolutionary history of the universe



I find every known religious cosmogony model to be laughable stupid!

There are some very clever agnostic models of the universe. All such models are silent about the values of free variables needed and source of physical laws. That is what this essay is about.

The fact that a bounce free model (like Hawking’s) willalways have variable value problem and unaccounted for physical laws is self-evident. There is a strong anthropomorphic principle needed, the universe selected must allow observer as us to exist and hence the selection bias is one tuned to our existence from all models. Intelligent life may exist in other models. Every consistent model defines a possible in the multiverse, but uninteresting since we have no access to such universes! I do strongly believe in filtering anthropomorphic principle but no use for argument!

The values are those from the previous contraction of the universe and one must demonstrate the values as possible from contraction. It looks like electron charge, value of edge or radius of smallest cell (planck length), gravitation constant and fine structure constant will have to be explained by the contraction of the previous universe. Contraction must also explain the space density at which the bounce occurs.
The laws cannot be such that they preclude our existence. That means all inconstant law sets. A law set consistent with intelligent life may be lead to inaccessible universe but cannot be ruled out.

Interestingly, quantum mechanics is essential because without it, random spontaneous events are not possible, which can eventually lead to intelligent life. It was slowly spontean0usly created and was retained in the chain leading to us. Other laws have to derived from first principles from the previous contraction. QM is essential to intelligent life created solely by evolution.

Closest to my cosmogony is loop gravity, except that I do not think that the bounce happened once but infinite times till our universe which finally seems to be ever expanding and ever-safe.

The reason for contraction of all previous editions is the quantum mechanical increment to the dark energy of subsequent editions. It is not required but lovingly useful that our universe edition will expand forever, even if accelerating.
There are no limitations (even probabilistic) requiring A FINITE UPPER LIMIT BASED ON ANTIFRAGILITY! In other words, immortality is logically possible – individual and support groups.

Eventual immortality requires upload, likely only in thousand years. Transfection will give you the thousand years, due in fifty years. NMN+K2 will likely give me those fifty years.
 There is no harm in trying since each step leaves me healthier body till probabilistic dangers of death. Its only this that fills me with agnostic faith, I live in spite of the universe and need no paid support. I am not a guru, professorship was long ago, I thrive despite unfavorable death level events as TBI, heart-pain and food-poisoning. Like ancient stoics, these leave me stronger!

Sunday, November 25, 2018

Tech fi ready to be born




Tech fi ready to be born


First get inspired, I feel sorry for self not anticipating-

Or

MIT engineers fly first-ever plane with no moving parts | MIT News



Now aahindi/aaquantum insight. What is described if a propulsion system without moving parts. – unmove engine Airplane just one use – wheeled are not excluded. So how about  nomove engine and attach it for unmoveing train, truck, tank etc?



Long youth century 21




 Texas businessman with a family history of dementia recently announced he would award $4 million in prize money to researchers who search through published scientific studies and knit the findings together into a unified explanation of how Alzheimer’s works.

No millionaire or prize is needed for motivation since age-sickness will strike me – it is not familial chances.

 WebMD Feature

Reviewed by Neha Pathak, MD on August 22, 2018 [all except text in [] ]

[ WebMD pronouncements, good or bad are as good as conventional medicine doctors average, which is very good for lay persons, both as what to do and judge anything different as perturbations based on referenced arguments.

After several years of hard skeptical but rational research, I am ready to summarize my learning, as I do here. The goal, as Dr. Sinclair puts it, it is not people living longer, but extending their youth. Even if later empirical tests prove a lack of age increase, unlikely but possible, the reader and implementer gains enormously from the quality of life!

The solution is some cocktail of vitamin B3 forms and supplements metformin, MK7+D3+Ca, and CoQ10 (direct or mitochondria entering). The forms of B3 are niacin (flushes) or nicotinamide (non-flush niacin), NR (2 steps to NAD+), NMN(1 step to NAD+), NAD+ or NADH (REDUCED NAD+).

Why a cocktail?

The forms vary enormously on costs, bioavailability and cells improved! The goal is NAD+in each case as an essential part of Kreb cycle in every cell. All forms of B3, or any other aging intervention must target NAD+! There is age-long diminish of NAD+, it is a reliable measure of bio-age, even better than telomeres!

Bioavailabity?

Me: It is the essential difference between a doctor and biochemist. Just because a chemical is found in a particular plant means nothing and is the principal difference between nutritionist and a subhuman passing as capitalist sellor, advisor, company, doctor, biochemist etc. In each case, the subhuman will be incapable of referencing the right material or reference bad or controversial matter. One who does is a scholar. One who does not is a subhuman! In argument, one or both scholars may differ and be wrong, a subhuman is always criminal, whether right or wrong. It is possible to detect subhumans without deep knowledge of any subject and I suggest they should be treated as criminals.

Bioavailabity is to get the chemical in usable shape at the right place. In current case, the chemical may have transportation losses, aging losses, blood entry losses in stomach, blood-brain barrier interface losses, cell-wall penetration losses and losses from entry into mitochondria. Reserveratrol is excellent example, you get it in red grapes which has to eaten by tonnes or hundred of gallons as red wine. Glutathione is another skin lightening anti-oxidant, very poor bioavailability unless given as drip! NMN is another, easy bioavailability for mice (in drink) but very poor in humans. They must either take it in drip or sublingually.

Sublingual is possible in some cases, like NMN, when the molecule is small, it is like IV direct. Another matter is easy intra-muscular (like insulin injections) or intravenous (requires training)

Niacin/nicotinamide do not significantly become NAD+, but crosses into brain and helps Parkinson/Alzheimer patients. Only NR crosses into cells but NAD+ and NMN spontaneously become NR! NADH crosses to brain, as does NAD+.

There is a war between believers in NR, NMN, NAD+ and NADH. It is empirically known that they effect different cells differently. Which is why I think of a cocktail depending on who to help.

No matter what form, IV route is best. USA costs are $1000 per day i.e. $13,000 (10 day) to $30,000 (28 day) per treatment Me: Ideal for Indian medical tourism! I start with drip (B3 cocktails), ECP and HOT. It is $1500 in premium coach for USA-India back and forth. Great use of my real estate assets and cost  or quality uncompetable medical tourism. International airport near Greater Noida will be ready by 2022! I can also pay for eScooter fare to IG airport at palam.

Beyond that, there is sublingual glutathione, self-injectable nmn etc as product ideas.
]



How Vitamins Can Help
Older adults have different needs when it comes to vitamins and minerals. For example, the right amount of calcium can help fend off osteoporosis in women. Vitamin D, which helps your body take in and use calcium, also helps prevent bone loss and broken bones in older adults.
It’s sometimes hard to know exactly what you need. But if you have a balanced diet, you’re probably doing OK. If you’re still concerned, Robin Foroutan, a nutritionist from New York, suggests you ask your doctor if supplements might help.
Before you head to the store, though, it’s important to know the term “supplements” includes not only vitamins and minerals, but also herbs and other botanicals, amino acids, enzymes, and other things. Some are so-called specialty products like probiotics or fish oils.
Before you take anything, talk with your doctor and read labels.
What Might I Need?
You can find these in foods or on the supplement aisle:
Calcium. “There really should be no reason that people should be calcium deficient,” says Angel Planells, a dietitian from Seattle. Known for the role it plays in making your bones stronger, calcium is found in dairy products like milk and yogurt. Women -- especially those who are likely to have osteoporosis -- may think about taking calcium supplements. But talk to your doctor first.

Vitamin D. This nutrient, made by the body from sunshine, helps you take in calcium and phosphorus, so it’s key for healthy bones and teeth. Older adults don’t make it as well, so supplements can help make you less likely to have bone loss and broken bones.
[
Most Indians and westerns elders develop Osteoporosis, even if adequately supplied with calcium and D3. Japanese much less for their diet has natto (soybean -> k2). Like K1 a quinone, but not heart enemy like K1. Probiotics in human gut do convert some k1 to k2 in some cases (K1 essential for blood clotting, why heart enemy). Available as MK-4 (only japan allows) or MK-7 (empirically better than MK-4. Ideally supplement with k2, if calcium and d3).

Fascinating was hospital dietician (after food poisoning admit) who was not clear on vitamin k2 last month! Try in your place!
My theory is k2 by supplements essential menaquinone like MK7, PREVENT wrong deposit of Calcium in blood-vessels where they cause arthritis, kidney stones etc! MK7+D3+Ca essential for strong bones to avoid the topmost Osteoporosis problem post age 90, essential before for comfortable aging. As my mother says, hell is on earth, with slip in bathroom and 3 month elevation of cast legs, confined to a bed!
]

Vitamin B12. This is important for keeping blood cells and nerve cells healthy. Aging affects how well you take in and use B12 from foods, so if you’re over 50, it’s probably best to get your B12 from supplements and B12-fortified foods like cereals, as well as foods that are rich in it, like meat, low-fat dairy, and fish.

[ Very cheap in India in Modicare, stupid if not used as supplement, anecdotal helps]

Folate. This helps prevent anemia. Spinach, beans, peas, oranges, fortified cereals, and enriched breads can have it.

B6. This helps your metabolism and immune system. You can get it in fortified cereals and soy products, as well as organ meats and whole grains.

Your body also needs these:
Vitamin C. Oranges, right? (And red and green bell peppers, along with other vegetables and fruits.) It may help protect you from cataracts, help wound healing, and possibly lower your odds of having certain kinds of cancer.

Magnesium. Among other things, it helps keep your blood pressure and blood sugar levels steady. It’s also good for your bones. You can get it in nuts, spinach, and dairy products, and it’s used to fortify some breakfast cereals. Experts aren’t sure how well it works as a supplement.
And here are some popular items you can find in the supplements aisle that you might talk with your doctor about:
Probiotics. Gut health is also very important for your immune system. Some studies show that probiotics -- living organisms like those found in yogurt -- help prevent some types of diarrhea and ease symptoms of irritable bowel syndrome.

Coenzyme Q10. Also called coQ10, this is made naturally in your body and found in most body tissues. It may help your immune system work better.

Melatonin. A hormone released mostly at night, it’s believed to help you fall asleep. The science on it is promising.


https://www.webmd.com/healthy-aging/over-50-nutrition-17/vitamin-essentials-as-we-age

Thursday, October 4, 2018

NMN week1

   Latest link


1.   Week1 later (from start), NMN is already GREAT for diabetes! I wanted to establish a baseline of blood-work and too slow in the first week! NMN HAS been recommended as diabetes medicine by a US doctor! He considers age improvements like metformin. So I am doing 3 right things -= Stevia, metformin and NMN! Even if Parkinson forces me to be bed-ridden, I can medicate by supplements for the day when stem cell fix are less research and more medical practice.

2.      Reporting baseline numbers
1       HJgA1C – 6.5 worsening de o mango season
2             LDL 47 HDL 40 VLDL 24 TC 71
3       CRP .75

Bad but not terrible. Goals are
1                 HgA1C 5.6
2                 TC 50 HDL 50
3                 CRP 0.50

TNF is Rs. 4000/ I6F has not been even price asked. For that kind of money, doc consultation needed. Will happen in week 2



4.      Notice that I fight hard about insulin and sulfonylurea (kick the pancreas) drugs as empirically bad, they reduce life, FUCK the ancient or current opinion re safety of insulin of medical schools that taught the current doctors! You can fix Sugar concentrations two ways (Very important to control) – improve its utilization and block its entry! Bad ones are all improved utilization. Block entry is metformin works on liver, acarbose on absorption from stomach, both ok. I think doctors think “insulin is good because is needed by young adults and is bad in 50+ age” is bad opinion against what is taught and practice. Unaware of newly collected data in last 20 years! “Metformin to 3000 mg and acarbose since” That’s my advice if NMN is NOT available, my loud advice and empirical shastrarth with doctors!

Friday, September 28, 2018

Personal reported experiences




1 Dr. Sinclair discovered it, followed scientific rules, reported results at Harvard. Feeds his father – first Resveratrol now NMN. He could afford before. I can now.

2

3
Taking my cue from above, I need sugar profile, lipid profile and inflammation profile. Means

Sugar: Hba1c, daily readings
Lipid: LDL, HDL, triglycerides

4
I expect and will test above.

[Diabetes] Sugar, expect HgA1C of 5.6 or lower after 6 months, now 6.5
[Heart] Lipid maintain curent wonder 47 LDL < 100, 40 HDL > 50, 101 Triglyceride < 120
[body Age] Inflammation: 0 .75 CRP  0.5, TNF <= 0 .5, I6P <= 1.0
NOTE THAT BY ada GUIDELINES, <100 AVERAGE IS NONDIABETIC 5.0

I test with 500mg NMN sublingual, go to 750 mg sublingual if UNLIKELY fail in goals, reduce to 250 mg/day if met unlikely very well! I suggest weaker drugs, not placebo, weaker switching to higher doses, for trials. BASED ON nmn STOPPING, i WORRY ABOUT INFLAMMATION = AGE AND LIPIDS = HEART. Nothing human can keep my NMN away!

5

To be a scientist, one must be a rational doubter, none better than ScientificAmerican!

6
morning sugars day1=sep27 seems to gyrate around 110 now with < 100 GOAL
1) 122 2)114 3) 100 4)112 5)99 6) 106

Improvement so fast! My sugars were near 120! Uniformly under 100 means non-diabetic!
NMN helps in body aches. Might even remove need for nortryptalline fore head injury headeaches and leg pain on sleeping in a.c.! Also heart meds for LDL and HDL! NMN IS modern wonder better than anything in 5000 years of medicine.

7
I am NOT going to be a spokesperson or have annotated support! Every patient sees improvements after expensive procedures - usual citizen reports for medication are massive idiotic, anecdotal praise abusively lie based, and NOT be admitted! Only improvements I admit are blood-work readings. I will set up my baseline in this week and compare it with readings in 3 months.

8
Modi has done THE absolute great thing - common medicine at 10% the price! Suddenly Modi is not just a good but person to sacrifice life for and true Fuck of opponents! It probably matters not or may be does, my anti-corruption through encryption will start working and enable a true gift from me!

Monday, September 24, 2018

Start with NMN- self-directed study based on Dr. Sinclair



Philosophy:
 Ageing Res Rev. 2015 Mar;20:46-62. doi: 10.1016/j.arr.2014.11.005. Epub 2014 Dec 19.

Sinclair: 

MIT PhD, tenured faculty Harvard Medicine, Discovered Resveratrol and Siruins, Could afford 10 yr. self-test for Resveratrol and NMN for self and father (after IPO a billionaire), NMN now $700/year, mice experiment great, NASA appointed director for Mars astronauts, truly liberal Giant running Lab through crowdfunding!

Goals:
               Duration 3 month. Can reasonably decide thereafter!
               What: 500 mg/day 4 sublingual doses, wakeup, sleep, and 2 diabetic intervention subsumed
How: Dissolve 3gm per week in 12 ml water, intake under-tongue by eye-dropper of 3 cc

POINT:

1.      Solution stable for 1 month
               Too low for external seller company
NMN very soluble water, easy to do it (once per week, eye dropper sublingual)
2.      Plenty of EMFUBAR capitalist selling 50 mg and/or or in ingest form (Why bad? Entry amount near zero, too small amount, likely MANY consumers fooled)
3.      Method adopted blessed by my seller
4.      I have covered NMN in past, see no reason to repeat – Aging medicine is here, NOT FDA approved yet. TRY ONLY ON SELF RISK AFTER EXTENSIVE READ.

NMN, Resveretrol, & Sirtuin - How to live a lot longer - with a pill? David Sinclair

Thursday, September 13, 2018

Stem cells - Parkinson and aging




Stem cells are basic to rejuvenation, as much as NAD+ improvements through NR, NMN, Niacin methods. The latter are like broad spectrum antagonists and work on variety of conditions like aging rejuvenation, weight control, cellular regrowth etc. Stem cell fixes are specific. Note that there are two of four ste4m cell kinds useful to us, mesenchymal and iPS. iPS are obviously better but could not be generated before publication in July 2018 of even a research! Noteworthy is what it means – at start of your life, you were a  totipotent built by union of cell from your mother and father! That gradually multiplied and built into iPS body + placenta, later multi-potent mesenchymal cells. Latter multi-potent cells are delivered to the region of interest so that they can specialize and divide in the interest region.

iPS are pluripotent i.e. can specialize into any mesenchymal. What you were at creation union were totipotent – pluripotent and also placenta specialization. This additional capability is no longer needed for rejuvenation.

You can become a modern day doctor for lack of long term medical education is no longer needed – delivery requires hypodermic solution – a skill very common. SCIIT can specialize into supplies of injectable stem cell delivery very similar to tooth labs or blood draw. It can deliver its products to doctors initially who can extract the skin cells or mesenchymal cells directly. They may need quality chemical processing for which SCIIT exists. The results are injected into the patient. It is essentially like blood draw system. Unlike every other mm method, there are NO unexpected side-effects as the pat5ient is injected its own stem cell! Long study and experience are solely needed for side effects which governs ingestion timing, amount and duration.

Rejuvenations possible without doctors

Doctors hate rural postings. With widespread video-connected coach-mounted equipment and low-skill stem cell fixes, one can and will build a low cost excellent health service net. Let us call my model STEM for ultra-modern-medicine. It can and will do far better than any competing homeopathy and better than any Ayurveda or Unani. It is sign of my contempt for products of Indian medicine education that it will do better than 60% of allopathics too!
I am working towards SCIIT and STEM. We will see in 5 years, won’t we!



Reason to shoot for 150 years is 1 above. Currently chased is 2. I am not interested in use of hibernation to extend life – while the total life is extended, waking time is not! The choice-death will happen in stages

1.      Stem cells to 150

2.      Transfection to 3000

3.      Download-consciousness for choice-death.

I am very close to determining whether I just wrote sci fi or not.