Problem of plenty in Aging

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After 20 year side interest and major extensive interest in Aging for last 10 as I age, its biology and chemistry, blessed with sharp intellect that took me to the Unix group at Bell labs as colleague to Dennis Ritchie and two computer science seminars at Harvard, I can state as a self-styled expert in Aging that unlike my past, there are five methods of Aging reduction that are likely independent and hence composable. It is not known how effective each is, nor is composing method of mine sensitive to scientific answers, enough anecdotal evidence exists for some effective of each, benefits may exist that are varying for each client, still my composition is not sensitive to such variations.

self-applicative and FDA test routes

That brings me to value of my knowledge. Being a top doctor or scientist means nothing. Even statements of two greats, Dr. Sinclair and Dr. Aubrey de Grey only means they will be carefully considered but not consider to be cardinal objective truth. There are precisely two methods that massively defeat all the others, all of which including evidence from a theory, religious tome, Guru, great, article etc. are all considered junk. The methods are transparent self-application or FDA directed clinical tests, since aging is distinct from all other diseases, all grow old and I have internal natural right to demand that any recommenders of anything apply it to themselves and family first. Dr. Sinclair does it to self and family. So do I. Dr Grey has followed clinical route. So has Dr. Sinclair eventually. Great past helps, is suggestive, but does not guarantee anything. Self-application is because FDA process is too slow and will unacceptably remain so, in Aging medicine for centuries, even though accurate.

self-application risk

What are the things I claim to understand well enough to risk self and family? I think Dr. Sinclair theory of Aging as progressive error in error correction in epigenome. He calls it the theory of information as the effects of errors makes that make cell senescent and essentially useless and a burden. In youth, there is no problem as the immune system is strong and such cells suffer apoptosis or forcibly are cut, garbage-collected and expelled through urine. I took a calculated risk for I grow old. My family came on board after 3 months of wait and watch.

How are you different?

All my recommendation are usually for liposomal form, unless explicitly denied. All my recommendations are for materials available as supplements.

Arya-safe: increased concentrations of chemical names of contents of fruits and vegetables, chemical names of stuff already in the body,  GRAS status in the USA law, doctor managed medication available OTC in some major country without prescription but requiring prescription in others, or vitamins. No concentrations are suggested to known poison levels. 

Adoption of this discipline enables me to state that I do not play a doctor, no disease cure is suggested, no responsibility is assumed, all is for consideration of doctors, and critics suggesting otherwise are emfubar sub human. Liposome very significantly change dosage due to greatly improved bioavailability and only a doctor can suggest proper dose and titration to it.

What does your study and experience so far indicate for the theory?

Several great doctors have worked on the methods. My innovation is collecting the successful in isolation in a theory that suggests the method in a logical manner. I call it “the theory and practice of aging”. That is standard science that collects many empirical results into a whole which suggests the empirical facts. Hopefully new ideas will be suggested beyond those derived with difficulty in isolation. As I proceed, certain observation are litmus tests for any other theory! Never accept a theory that fails even 1 litmus test!

Problem of plenty

There are five distinct, independent (now) approaches to aging, meaning they are statistically independent, hence likely composable with effects that add and composable howsoever in parallel and sequential modes. These are mTOR, telomere, immune refresh, Yamanaka factors, and E5. The last 2 are in the future within 2-20 years, and it is essential that reasonable healthy persons be there when the expectation matures. My different recommendations apply to different self-assesed people.

1. Religiously inclined

2. Conservative science inclined like me

3. Liberal inclined

Religiously inclined

Included here people who consider the body divine which should not be defiled by adding untested drugs which have no doctor-blessed history. They are included because mTOR based methods have dietary restriction and time-restricted methods. No chemicals need to be used these two techniques. Empirically, mice experiments prove that best is single meal, however large and howsoever constructed. You must fast 1day a week, week-long per month, etc. Fasting does auto-phagy (junk collection) after 16 hours after a meal and a lot in long fasts. Should avoid all comforts. The mTOR paradox applies, as all mTOR methods apply and all comforts are evil!

Conservative science inclined

Science inclination means typical conservative low for religion is missing and the source of ethics if different. Human body is not considered sacred. Conservative means respect for traditions and harder acceptance of new results. Clearly FDA approval is gold standard but aging drugs are special. Here Arya-standard is used. Doctors are collected in groups based on their work so far. Only when their name is attached to a distinct element accepted by my theory, are they considered equivalent to Nobel laureates. Only when active after first work and a second Nobel-equivalent work do they rise to greats of Arya-standard.

Liberal inclined

Such a person is inclined to new things, just different, without serious consideration of the reason. Conservative shop owners and producers love him for the person loves new fashions and subscribes to the belief that tradition minded conservatives are stupid. Such persons were instrumental in the USA to destroy racial and sexual discrimmination. However being science inclined conservative gives me to oppose these discriminations as essentially for they have no scientific basis and hence are equally evil. The point here is that all science+conservative recommendations apply.

Who are greats of Arya-standard?

Name                Why                                                    Where

Sinclair              Resveratrol+NMN+Self-apply              Harvard

Kennedy           Buck+CaAKG                                        Singapore

Horvath           Bio-age/human+Bio-Age/animals            UCLA

 Israel                Divers+ HBOT                                       Israel places

Fahy                hGH+DHEA+Metformin                            Stanford

Yamanaka        Y factors+pluripotent cells                        Japan

Compatible theory unifying their methods to make them suggestions of the Arya theory

Following the very dense next paragraph covers the entire field of aging.

From Hallmarks of Aging represented as a directed acyclic graph or dag one can isolate a dominating subgraph that covers activation and inhibition edges. Two methods suffice to cover 3 (Sirt, AMPK and mTOR) addressed by Dr. Sinclair and 1 by Dr. Fahy. Now one can imagine other forms of age reversion. Not doing Fahy (suggests igf-1 fix) and Sinclair (suggests NMN for Sirts, Metformin for AMPk and rapamycin for mTOR) yields senescent cells which hurt by bad chemicals and by induced senescence in neighbors. This immediately leads to senolytes and Dr. Aubrey de Grey (Spermidine, Fisetin, Quercitin, apigenin etc depending on senescent cell source). How is bioage measured? . These are not just marker but residue of DNA operation and specialization of the cell! Fixing the process not only improves the epigenome but manipulates age! Dr. Kennedy AKG comes here.  How come the senescent bother the old but not youth? Because of active immune system that declines with age. Fix it by cancer developed methods like car-t fix. Finally, cells have DNA overlain by two plugs on each end that shorten in every division until the cell turns senescent from inability of division past this Hayflick limit. One can fix this by two methods - extending the limit to infinity by cell developed enzyme that uses the DNA sequence that encodes the ligase DNA present but deactivated giving rise to deathless cell line also called cancer. Or by diver-like HBOT use. Last is the famous Israel method. The manipulation of telomere length seems to have aging reduction applications. Intermittent brief Yamanaka factors arena-toxic and refresh the cell without losing specialization assuming only OSK are used. E5 likely uses exosomes and depends on the fact that these serve to be like hormones without using generation organs!

Remedy mTOR

 

mTOR is the kinase that determines the overall body state into 2 categories – comfort and adversity. It is a very important discovery of evolution and plays a similar role in all animals, including yeast. On adversity, it signals autophagy and reuse signals – destroying unfixable garbage proteins that can not be repaired. In effect, it increases age. The autophagy process is central to cancer cures and deserves its own section.

 

When the body determines comfort, there are no evil events to comfort of body, food is plentiful, enough sleep is missing, it loves the comfort and proceeds to shut adversity pathways, i.e. declares comfort, feels and looks healthy, but is bad for age! 

 

Unlike animals, we are at the top of the food chain, are not cannibals, and developed environment improving technological evolution, so are no longer subject to biological evolution because tech-evolution outpaces bio-evolution by a factor of 1000 and I think that tech-evolution products make bio-evolution based success definitions easily targeted by tech-evolution products. I include brain developments given the successes in AI which render man-machine systems or cyborgs distinctly superior.

 

The mTOR puzzle is all comforts weaken aging processes. So, how can full-grown adults ramp up autophagy, cool the mTOR jets a bit – and ultimately age better and more slowly? Here are a few simple natural ways to get into the groove:

 

1.   Eat a bit less: To tame mTOR activity and trigger more autophagy, simply restrict calorie intake. One safe way to do that (absolutely no starvation allowed!) is with brief periods of caloric restriction (we’re talking hours at a time, not days). You can try approaches like intermittent fasting (IF), time-restricted eating (TRE), alternate-day or modified alternate-day fasting, or the 5:2 approach.

 

2.   Pile on plants: Animal proteins, especially red meat, contain high amounts of branched-chain amino acids like leucine, which stimulate mTOR. Plant proteins contain considerably less, so they won’t stimulate mTOR nearly as much. No need to swear off all animal protein (as in, meat, dairy, chicken, fish, eggs), but, in middle age, the average person would be wise to eat a lot less of it, ideally keeping daily protein intake in the 55-gram range, with most or even all of it coming from sources like almonds; broccoli; chickpeas; cruciferous veggies; hemp powder; lentils; onions; pea protein; nut butter; sunflower seeds; tempeh; turmeric, etc. For the 65-and-over set, it’s fine to ramp back up a bit to 70 grams daily to help minimize age-related muscle wasting or sarcopenia. 

 

 

3.   Add a little stress: As in the healthy, physical kind. In small doses, the healthy stress of moderate exercise – think walking or light jogging versus Ironman competitions or climbing Mt. Everest – encourages better aging via “hormesis.” Hormesis is your body’s response to small stresses—think fasting or caloric restriction for short periods; biking up a short, steep hill; or brief bouts of cold exposure. These bursts of adversity toughen up the cells and the body’s defenses against aging. 

 

4. Embrace mTOR tamers: To help tame the mTOR beast, you may also wish to augment your plant-based diet with a few supplements that can keep it – and aging – in check. Among my favorites: 

• Alpha-lipoic acid – Dosage: 300 to 600 milligrams per day (non-meat-eaters should aim for the higher end).
• Curcumin – Dosage: 500 to 1,000 milligrams twice a day. Take it with good fats, like avocado, so it can be properly absorbed. Add turmeric to your cooking too.
• Quercetin – Dosage: 500 to 1,000 milligrams per day. Best when paired with vitamin C or digestive enzymes like bromelain to aid absorption.
• Resveratrol – Dosage: 200 to 300 milligrams per day.
• Fish oil – Dosage: 1 to 3 grams per day.

 

5. Get your sleep on Getting high-quality shut-eye, think 7 – 8 hours a night, to help stoke your autophagy engine. Studies show that sleep deprivation encourages increased mTOR, so don’t skimp on this health-maintaining activity.

6. Adjust the temperature up and down: Swim in a cool pool, then dip in the hot tub or sauna (or vice versa); add a brief cold finish to your hot shower; or simply or spend a few minutes outdoors in the cold lightly dressed. Swinging back and forth between cold and hot will lightly stress your cells enough to encourage autophagy and keep mTOR at bay.

 

 

The telomere approach to Aging

 

There are five distinct, independent (now) approaches to aging, meaning they are statistically independent, hence composable with effects that add and composable howsoever in parallel and sequential modes. These are mTOR, telomere, immune refresh, Yamanaka factors, and E5. The last 2 are in the future within 2-20 years.

Beyond mTor with several Approaches to Aging, there is the telomere lengthening approach, lengthened by the diver approach or hyperbaric oxygen. When I approached it six months ago after the method being there for about a year, telomere extensions were known as in professional divers, but not referenced with guisto and soon very negative things by Dr. Aubrey de Grey who I respect most. It was unclear whether the elongation reduced age, the latest says it does, a reputed Israeli scientist writes. The method is the best of the lot since HBOT short term has another well-known use by film stars to enhance their beauty and properly done. one can find many marriage applications. In fact, the Glutathione chemical has anti-aging and skin-whitening applications! I desisted as intravenous use was needed but now have discovered liposome suppliers, thus going beyond intravenous use only!

One of the more spectacular uses of HBOT, recognized even by conventional American medicine, is its powerful detoxification benefit. Thus, given that your skin is not only your single largest organ but also plays a major role in detoxification, and given that toxins in your body definitely show up as skin blemishes and discolorations. Thus removing toxins and the aesthetic benefits to your skin are shown outwardly.

Hyperbaric enhances beauty and finds applications post plastic surgery. According to Wu Jianhua, a famous Chinese doctor in the field of hyperbaric oxygen therapy， the effect of hyperbaric oxygen therapy on beauty has three aspects.

1. Repair after cosmetic surgery: cell tissue promotes wound healing in a high-oxygen environment; leukocyte phagocytosis under hyperbaric oxygen is enhanced, which can prevent infection, repair necrotic cell tissue after surgery, and make wounds heal faster in hyperbaric oxygen after surgery, Better, so as to achieve the purpose of beauty
1. 
   

      2. Promote skin cell metabolism: Hyperbaric oxygen treatment promotes the synthesis of skin collagen, which can increase the elasticity of the skin; it makes the skin capillaries richer in blood oxygen, which can achieve better nourishment of the skin cells, Isreal Hyperbaric making the complexion ruddy; it is the blood and skin The nutrient exchange between tissues is sufficient, and the skin is more moisturized, smooth.   

      3. Fight against UV damage: A study by the University of Connecticut found that hyperbaric oxygen therapy has a very significant inhibitory effect on skin cell proliferation, cell death, and apoptosis caused by UV rays, and can significantly reduce skin wrinkles caused by UV rays. The depth and quantity increase, increasing skin elasticity. It is necessary that hyperbaric oxygen may have the effect of preventing and curing skin damage caused by ultraviolet rays, which means that hyperbaric oxygen may have cosmetic effects. Researchers believe that the root cause of UV damage is the preconditioning effect of hyperbaric oxygen.

It is available in India !!!! India. Hyperbaric Oxygen therapy (HBOT). A Natural Therapy for Anti aging, Wellness, Cosmetic Clinics & Spa.

It will cost 10-20 lakhs, I don't have it, but my mother is interested in family applications. Whether or not commercial applications fly is secondary, great if so,  ok without. That is the best approach to a business, can be very strictly honest! If my aging clinical test works  (looks great mid-term), completed by bio-age test before November, it is another very strict honesty and perhaps one can find synergy between two simultaneous independent anti-aging methods. So I start today on "Anti-aging and enhanced beauty shop". Delhi/Ghaziabad area. Will become global when Modi/Yogi Zaver airport is done in 2 years. Starting rentals in Greater Noida next to the airport site close to the airport ASAP. 

mTOR puzzle remedy

 

mTOR is the kinase that determines the overall body state into 2 categories – comfort and adversity. It is a very important discovery of evolution and plays similar role in all animals, including yeast. On adversity, it signals autophagy and reuse signals – destroy unfixable garbage proteins that can not be repaired. In effect, it decreases age. When it determines comfort, there are no evil events to comfort of body, food is plentiful, enough sleep is missing, it loves the comfort and proceeds to shut adversity pathways, i.e.  declares comfort, feels and looks healthy, but is bad for age! Unlike animals, we are the top of food chain, are not cannibals, and developed environment improving technological evolution, so are no longer subject to biological evolution because tech-evolution outpaces bio-evolution by a factor of 1000 and I think that tech-evolution products make bio-evolution based success definitions easily targeted by tech-evolution products. I include vrain developments given the successes in AI which render man-machine systems or cyborgs distinctly superior.

 

The mTOR puzzle is all comforts weaken aging processes. So, how can full-grown adults ramp up autophagy, cool the mTOR jets a bit – and ultimately age better and more slowly? Here are a few simple natural ways to get into the groove:

 

1.   Eat a bit less: To tame mTOR activity and trigger more autophagy, simply restrict calorie intake. One safe way to do that (absolutely no starvation allowed!) is with brief periods of caloric restriction (we’re talking hours at a time, not days). You can try approaches like intermittent fasting (IF), time-restricted eating (TRE), alternate-day or modified alternate day fasting or the 5:2 approach.

 

2.   Pile on plants: Animal proteins, especially red meat, contain high amounts of branched chain amino acids like leucine, which stimulate mTOR. Plant proteins contain considerably less, so they won’t stimulate mTOR nearly as much. No need to swear off all animal protein (as in, meat, dairy, chicken, fish, eggs), but, in middle age, the average person would be wise to eat a lot less of it, ideally keeping daily protein intake in the 55 gram range, with most or even all of it coming from sources like almonds; broccoli; chickpeas; cruciferous veggies; hemp powder; lentils; onions; pea protein; nut butters; sunflower seeds; tempeh; turmeric, etc. For the 65-and-over set, it’s fine to ramp back up a bit to 70 grams daily to help minimize age-related muscle wasting or sarcopenia. 

 

 

3.   Add a little stress: As in the healthy, physical kind. In small doses, the healthy stress of moderate exercise – think walking or light jogging versus Ironman competitions or climbing Mt. Everest – encourages better aging via “hormesis.” Hormesis is your body’s response to small stresses—think fasting or caloric restriction for short periods; biking up a short, steep hill; or brief bouts of cold exposure. These bursts of adversity toughen up the cells, and the body’s defenses against aging. 

 

4. Embrace mTOR tamers: To help tame the mTOR beast, you may also wish to augment your plant-based diet with a few supplements that can keep it – and aging – in check. Among my favorites: 

• Alpha-lipoic acid – Dosage: 300 to 600 milligrams per day (non-meat-eaters should aim for the higher end).
• Curcumin – Dosage: 500 to 1,000 milligrams twice a day. Take it with good fats, like avocado, so it can be properly absorbed. Add turmeric to your cooking too.
• Quercetin – Dosage: 500 to 1,000 milligrams per day. Best when paired with vitamin C or digestive enzymes like bromelain to aid absorption.
• Resveratrol – Dosage: 200 to 300 milligrams per day.
• Fish oil – Dosage: 1 to 3 grams per day.

 

5. Get your sleep on:  Getting high-quality shut-eye, think 7 – 8 hours a night, to help stoke your autophagy engine. Studies show that sleep deprivation encourages increased mTOR, so don’t skimp on this health-maintaining activity.

6. Adjust the temperature up and down: Swim in a cool pool, then dip in the hot tub or sauna (or vice versa); add a brief cold finish to your hot shower; or simply or spend a few minutes outdoors in the cold lightly dressed. Swinging back and forth between cold and hot will lightly stress your cells enough to encourage autophagy and keep mTOR at bay.

Common to all these methods is precisely join a monk in some religion! Why bother with creature comforts, great food, temperature likeness, sleep devoted comfort, when you can please the angels and increase life!

Spanish mTOR puzzle

 

Mi trabajo ha identificado 4 genes que subyacen en el dígrafo completo de las marcas de Hall del envejecimiento. Estos son Sirt1, AMPk, mTOR e igf-1. De estos, todos menos mTOR deben potenciarse para reducir/revertir el envejecimiento. La mTOR es fundamental para la comodidad humana y la evolución tecnológica para mejorar la vida humana a través de la comodidad. Todas menos la mTOR se potencian con la restricción de la dieta. El mejor envejecimiento es común en la naturopatía: tome a la pareja y sométala a una restricción dietética extrema sin piedad. Después de 3 meses, la restricción de alimentos está en niveles normales, pero la mayoría de los sobrevivientes comen menos que eso. De todos modos, los humanos se reducen a casi esqueletos. La restricción extrema de alimentos mata cualquier diabetes y estimula los genes. Este método funciona, pero no lo recomiendo: muy pocos sobreviven.

 

El mTOR (objetivo de rapamicina en mamíferos) es un rompecabezas. Cada avance tecnológico en nutrición y comodidad de la tecnología lo potencia. ¡Comer proteínas aumenta la mTOR! Si te ves genial, tu mTOR se ha potenciado, Cada comodidad lo potencia. Pero devasta el envejecimiento. Cualquiera que apueste por la longevidad debe detener su crecimiento. Hay un enlace boost de igf-1. Impulsarlo mejora la edad pero la reduce desde el enlace mTOR. En palabras, la hormona de crecimiento GH aumenta la edad pero también la reduce al provocar diabetes. El Dr. Fahy lo arregló con GH+ metmorfina+ DHEA, y yo lo haré con GH+ DHEA+Low-rapamicina en autoprueba. El punto es la dificultad extrema de la restricción dietética y mi deseo de lucir en forma, no debilucho delgado como todos los maestros del envejecimiento (Sinclair, De Grey, Fahy). mTOR es el centro del rompecabezas. Cada buena consecuencia de la evolución tecnológica {comida, músculo, comodidad contrarreloj, comunicación mejorada ahorrando no solo esfuerzo sino también tiempo). Un maestro Sinclair habla muy bien del frío (todas las mañanas de caminata en la nieve sin camisa, con el pecho desnudo), baño combinado Sauna/agua helada, una comida/día, etc. Estas no son mi razón para vivir mucho tiempo. Soy un animal elaborado por la evolución biológica seleccionado principalmente por la evolución biológica para escapar de la depredación antes de la multiplicación fructífera. No importa que los mismos procesos de crecimiento de los primeros 20 años se hayan vuelto en mi contra. Creo en los miméticos químicos. Sinclair utiliza la vieja falta de conocimiento.

 

La inhibición de TOR aumenta el potencial regenerativo de los tejidos adultos

La rapamicina previene la pérdida de células madre relacionada con la edad

 

Resumen:

Las células madre adultas reponen las células moribundas y regeneran los tejidos dañados a lo largo de nuestra vida. Perdemos muchas de esas células madre, junto con su capacidad regenerativa, a medida que envejecemos. Trabajando en moscas y ratones, los investigadores descubrieron que TOR, una vía de detección de nutrientes que es fundamental para el proceso de envejecimiento, impulsa la pérdida de células madre adultas. El tratamiento de ratones con el inhibidor de TOR rapamicina previno esta pérdida y podría revertir la pérdida de células madre relacionada con la edad en la tráquea del ratón.

Es un gran paso para mí: ¡criticar al Dr. Sinclair! La falta de conocimiento a la hora de los hábitos hace que aumente los productos químicos con restricciones dietéticas comprobadas. Su última mejora mediante la adición de senolito de espermidina. Todavía toma ALA. Habla de miméticos de la adversidad evolutiva biológica para la supervivencia en períodos de escasez que conducen a los genes necesarios para los períodos de escasez. Nuestra revolución tecnológica (= evolución tecnológica) significa que no habrá más períodos de escasez.

 

Interruptor maestro

 

Hay un cambio de paradigma en mi forma de pensar:

En lugar de estudiar animales que envejecen rápidamente, el profesor Steven Austad cree que los animales que envejecen lentamente pueden tener las respuestas a la longevidad humana.

En particular, amplía la idea de que miles de millones de años de evolución ya pueden haber resuelto muchos de los desafíos del envejecimiento y la longevidad en algunas células de algún animal en la parte superior de su cadena alimenticia o muy difícil de cazar que actualmente estamos tratando de entender. y superar

 

Centrarse en los animales de envejecimiento más lento

Después de trabajar con zarigüeyas y otros animales durante algunos años, Austad decidió que lo que realmente necesitaba el campo del envejecimiento era estudiar animales que envejecieran lentamente, en lugar de aquellos que envejecieran rápidamente.

Austad cita el ejemplo de los murciélagos, criaturas que a menudo son incluso más pequeñas que los ratones y, sin embargo, viven durante décadas en buen estado de salud. Si bien no se consideran "exóticos" desde la perspectiva de un zoólogo, los murciélagos son ciertamente un espectáculo desconocido para la mayoría de los científicos de laboratorio.

 

“Ahora tenemos la tecnología de secuenciación del genoma y todo tipo de cosas para observar qué genes se activan y desactivan, y en qué tejidos”, dice. “Lo que creo que necesitamos es una especie de Proyecto Manhattan para centrarnos en algunas de estas especies que no envejecen, o envejecen muy lentamente, y descubrir cómo lo hacen”.

 

"También está Calico, a quien no le gusta hablar de lo que está haciendo, pero tiene una gran inversión en ratas topo desnudas, que también creo que es un animal muy interesante".

 

Brik febrero 18, 2022 a las 9:37 pm

Aquí hay datos aún más emocionantes para agregar: las ballenas de Groenlandia (Balaena mysticetus) son los mamíferos más longevos. Las ballenas árticas y subárticas viven cómodamente más de 100 años y pueden vivir más de 200 años, según la Administración Nacional Oceánica y Atmosférica (NOAA). Las ballenas tienen mutaciones en un gen llamado ERCC1, que está involucrado en la reparación del ADN dañado, que puede ayudar a proteger a las ballenas del cáncer, una posible causa de muerte. Además, otro gen, llamado PCNA, tiene una sección que se ha duplicado. Este gen está involucrado en el crecimiento y la reparación celular, y la duplicación podría retrasar el envejecimiento, informó anteriormente Live Science.

El pez roca de ojo rugoso (Sebastes aleutianus) es uno de los peces más longevos y tiene una vida útil máxima de al menos 205 años, según el Departamento de Pesca y Vida Silvestre de Washington. Estos peces rosados ​​o marrones viven en el Océano Pacífico desde California hasta Japón. Crecen hasta 38 pulgadas (97 centímetros) de largo

Los tiburones de Groenlandia (Somniosus microcephalus) viven en las profundidades de los océanos Ártico y Atlántico Norte. Pueden llegar a medir 7,3 metros (24 pies) de largo y tienen una dieta que incluye una variedad de otros animales, incluidos peces y mamíferos marinos como las focas, según el Observatorio de Tiburones de St. Lawrence en Canadá.

Un estudio de 2016 del tejido ocular de tiburón de Groenlandia, publicado en la revista Science, estimó que estos tiburones pueden tener una vida útil máxima de al menos 272 años. Se estimó que el tiburón más grande en ese estudio tenía alrededor de 392 años, y los investigadores sugirieron que los tiburones posiblemente podrían haber tenido hasta 512 años, informó Live Science anteriormente. Las estimaciones de edad llegaron con cierto grado de incertidumbre, pero incluso la estimación más baja de 272 años todavía hace que estos tiburones sean los vertebrados más longevos de la Tierra.

Las Turritopsis dohrnii se llaman medusas inmortales porque potencialmente pueden vivir para siempre. Las medusas comienzan su vida como larvas, antes de establecerse en el lecho marino y transformarse en pólipos. Estos pólipos luego producen medusas o medusas que nadan libremente. Las Turritopsis dohrnii maduras son especiales porque pueden volver a convertirse en pólipos si están físicamente dañadas o mueren de hambre, según el Museo Americano de Historia Natural, y luego regresan a su estado de medusa.

Las medusas, que son nativas del mar Mediterráneo, pueden repetir esta hazaña de revertir su ciclo de vida varias veces y, por lo tanto, es posible que nunca mueran de viejas en las condiciones adecuadas, según el Museo de Historia Natural de Londres. Los Turritopsis dohrnii son diminutos, de menos de 0,2 pulgadas (4,5 milímetros) de ancho, y son comidos por otros animales, como los peces, o pueden morir por otros medios, lo que les impide alcanzar la inmortalidad.

https://www.livescience.com/animales-de-vida-mas-largas.html

 

Rompementes febrero 19, 2022 a las 7:44 pm

No tenemos que elegir entre especies longevas y especies efímeras, ambas tienen utilidad. Al igual que el estudio de humanos de corta y larga vida e incluso el estudio de los grandes simios y el ADN de los neandertales, los denisovanos y otros humanos primitivos. Simplemente estudiar una gran cantidad de medicamentos y suplementos que ya tenemos en estudios de tejidos puede ser fácilmente útil. O incluso soluciones de ingeniería que no están presentes en la naturaleza.

No hemos estado estudiando ninguna de estas áreas lo suficiente como para justificar favorecer un enfoque sobre los demás.

También es probable que tengamos que encontrar soluciones para todas las formas en que envejecemos en lugar de solo mirar la metilación, los telómeros o el tálamo. O una docena de otros temas. Luego está la prevención y la reparación, que, por supuesto, no son lo mismo.

 

El rompecabezas mTOR

 Hay 3 formas independientes de reducción del envejecimiento independientes entre sí y, por lo tanto, se pueden realizar en paralelo: reducción de mTOR (rapamicina en dosis bajas), alargamiento de los telómeros (oxígeno hiperbárico) y reactivación del timo (reducción de la involución repetida). Cualquier persona inteligente puede comenzar desde aquí y buscar en mi conocimiento.

mTOR es básico para los miméticos químicos que nos permiten las comodidades de la evolución tecnológica dentro de las limitaciones de la bioevolución. Dado el ritmo y la calidad de los científicos en Neuralink de Ed Musk, espero descargas cerebrales antes de que termine el siglo y estar vivo para entonces. No importa el período de salud de 512 años de los tiburones.

 

¡El cambio de paradigma notable está en cómo obtener una vida sin fin!

 

1. Bioevolución con rejuvenecimiento/crecimiento ilimitado de extremidades y órganos.

2. Bioevolución con reversión periódica al estado de matriz

3. Descarga de Cerebro

4. Refacción periódica permanente de células madre y sistema inmunitario

 

¡En espera de mi fértil imaginación de ciencia ficción!

The mTOR puzzle

 

Abstract;

A remarkable paradigm shift is in how to get end-less life, to 6 independent paradigm, only one showing any progress!

1.    1.  With demonstrable progress, Bottom-up DNA methods with limitless rejuvenation.  There are five distinct, independent (now) approaches to aging consistent with bio-evolution, the rejuvenation arm of 6 ways to live for ever, meaning they are statistically independent, hence composable with effects that add and composable howsoever in parallel and sequential modes. These are mTOR based, telomere based, immune refresh, Yamanaka factors, and E5. [The last 2 are in the future within 2-20 years. At this time, no method has been shown to be reapplicable, leave apart indefinite times!]. Even 1 shot or small number of repeat is useful for transit to singularity.

2.     2. Bio-evolution with periodic reversion to womb-state as in jelly fish.

3.    3. Download of Brain to silicon and commanded robot bodies.

4.    4. Permanent periodic refix of stem cells and immune system. Thymus regeneration.

 5. With demonstrable progress, DNA methods with Yamanaka factors

6. With demonstrable progress, Top Down Stem cell E5 exosomes methods

end Abstract

My work has identified 4 genes that underlie the full digraph of Hallmarks of Aging. These are Sirt1, AMPk, mTOR, and igf-1. Of these, all but mTOR must be boosted for reducing/reversing aging. The mTOR is central to human comfort and technological evolution to improve human life through comfort. All, but mTOR, are boosted with diet restriction, mTOR reduces, all reducing aging. Best Aging is common in Indian Naturopathy – take the aged couple and subject them to extreme diet restrictions without mercy. After 3 months, food restriction is to normal levels, but most survivors eat less than even that. Humans are reduced to near skeletons anyway. Extreme food restriction kills any diabetes and boosts the genes. This method works but I recommend against it – very few survive to end. 

All modern conveniences increase mTOR, hence reduce age! Hence the puzzle. Even better food increases mTOR. Human progress reduces lifespan, though not health span always. People have shorter lifespans but longer health span in advanced countries. Technological evolution can lead to better longer health spans by some calorie restriction and chemical mimetics - fooling the body to believe shortages of calorie restriction are likely.

The mTOR (mammalian target of rapamycin ) is hence a puzzle. Every technological advance in nutrition and comfort from technology boosts it. Eating proteins boost mTOR! If you look great, your mTOR has been boosted. Every comfort boosts it. But it devastates aging. Anyone shooting for long life must stop its growth. There is a boost link from igf-1 to mTOR. Boosting gif-1 improves age but reduces it also from the mTOR link in Akt pathway. In words, Growth Hormone GH boosts age but also reduces it by instantiating diabetes. Dr. Fahy fixed it by GH+ metformin+ DHEA, and I will GH+ DHEA+L ow-rapamycin in the self trial. The point is the extreme difficulty of dietary restriction and my desire to look fit, not thin weakling as all aging masters (Sinclair, De Grey, Fahy} look. mTOR is the center of the puzzle. Every good consequence of technological evolution {food, muscle, comfort against time, improved communication saving not just effort but time as well}. A master Sinclair speaks great things for cold (all morning treks in the snow without a shirt, chest bare), combination bath Sauna/ice-water, one food/day, etc. These are not my reason for living long. I am an animal crafted by biological evolution primarily selected by biological evolution for escape from predation before fruitful multiplication. 

It matters not that the very growth processes of the first 20 years have turned against me. I believe in Chemical mimetics.  I believe in some aerobic exercise. I believe in some anerobic (weight lifting)  to fight sarcopenia. Both reduce mTOR. No mimetics. Sinclair uses an old lack of knowledge. I refuse to look weakling like the masters. 

 

Inhibiting TOR boosts regenerative potential of adult tissues

Rapamycin prevents age-related loss of stem cells

 

Summary:

Adult stem cells replenish dying cells and regenerate damaged tissues throughout our lifetime. We lose many of those stem cells, along with their regenerative capacity, as we age. Working in flies and mice, researchers discovered that TOR, a nutrient-sensing pathway that is central to the aging process, drives the loss of adult stem cells. Treating mice with the TOR-inhibitor rapamycin prevented this loss and could reverse age-related loss of stem cells in mouse trachea.

It is a very big step for me – criticizing Dr. Sinclair! Lack of knowledge at the time of habits means he boosts chemicals with proven dietary restrictions. His latest improves by adding spermidine senolyte. He still takes ALA. He talks of biological evolutionary adversity mimetics for survival in lean periods leading to genes necessary for lean periods. Our technological revolution (= tech-evolution) means no more lean periods.

 

Master switch

 

There is a paradigm shift in my thinking – 

Rather than study animals that age quickly, Prof Steven Austad believes animals that age slowly may hold the answers to human longevity.

In particular, it expands on the idea that billions of years of evolution may have already solved many of the challenges of aging and longevity in some cells in some animal at top of its food chain or very difficult to hunt that we are currently trying to understand and overcome.

Focus on slower aging animals

After working on opossums and other animals for a few years, Austad decided that what the aging field really needed was to study animals that age slowly, rather than those that age rapidly.

Austad cites the example of bats – creatures that are often even smaller than mice and yet live for decadesin a state of good health. While not considered “exotic” from a zoologist’s perspective, bats are certainly an unfamiliar sight for most laboratory scientists.

“Now we have the genome sequencing technology and all kinds of things to look at which genes are turned off and on, and in which tissues,” he says. “What I think we need is a kind of Manhattan Project to focus on a few of these species that don’t age, or age very slowly, and figure out how they do it.”

 “There’s also Calico, who don’t like to talk about what they’re doing, but they have a big investment in naked mole-rats, which I also think is a very interesting animal.”

Brik February 18, 2022 At 9:37 pm

Here’s even more exciting facts to add: Bowhead whales (Balaena mysticetus) are the longest living mammals. The Arctic and subarctic whales comfortably live over 100 years, and may live more than 200 years, according to the National Oceanic and Atmospheric Administration (NOAA).The whales have mutations in a gene called ERCC1, which is involved with repairing damaged DNA, that may help protect the whales from cancer, a potential cause of death. Furthermore, another gene, called PCNA, has a section that has been duplicated. This gene is involved in cell growth and repair, and the duplication could slow aging, Live Science previously reported.

Rough eye rockfish (Sebastes aleutianus) are one of the longest living fish and have a maximum lifespan of at least 205 years, according to the Washington Department of Fish and Wildlife. These pink or brownish fish live in the Pacific Ocean from California to Japan. They grow up to 38 inches (97 centimeters) long

Greenland sharks (Somniosus microcephalus) live deep in the Arctic and North Atlantic oceans. They can grow to be 24 feet (7.3 meters) long and have a diet that includes a variety of other animals, including fish and marine mammals such as seals, according to the St. Lawrence Shark Observatory in Canada.

A 2016 study of Greenland shark eye tissue, published in the journal Science, estimated that these sharks can have a maximum lifespan of at least 272 years. The biggest shark in that study was estimated to be about 392 years old, and the researchers suggested that the sharks could possibly have been as much as 512 years old, Live Science previously reported. The age estimates came with a degree of uncertainty, but even the lowest estimate of 272 years still makes these sharks the longest living vertebrates on Earth.

Turritopsis dohrnii are called immortal jellyfish because they can potentially live forever. Jellyfish start life as larvae, before establishing themselves on the seafloor and transforming into polyps. These polyps then produce free-swimming medusas, or jellyfish. Mature Turritopsis dohrnii are special in that they can turn back into polyps if they are physically damaged or starving, according to the American Museum of Natural History, and then later return to their jellyfish state.

The jellyfish, which are native to the Mediterranean Sea, can repeat this feat of reversing their life cycle multiple times and therefore may never die of old age under the right conditions, according to the Natural History Museum in London. Turritopsis dohrnii are tiny — less than 0.2 inches (4.5 millimeters) across — and are eaten by other animals such as fish or may die by other means, thus preventing them from actually achieving immortality.

https://www.livescience.com/longest-living-animals.html

 

Mindbreaker February 19, 2022 At 7:44 pm

We don’t have to choose between long-lived and short-lived species, both have utility. As does studying short and long-lived humans and even studying the great apes and the DNA of Neanderthals, Denisovans, and other early humans. Just studying a large number of drugs and supplements we already have in tissue studies can easily be helpful. Or even engineering solutions not present in nature.

We haven’t been studying any of these areas long enough to justify favouring one approach over the others.

We also likely have to find solutions for all the ways we age rather than just looking at methylation, or telomeres, or the thalamus. Or a dozen other topics. Then there is prevention and repair, which, of course, are not the same.

 

The mTOR puzzle

mTOR is basic to chemical mimetics that allows us comforts of tech-evolution within the limitations of bio-evolution. Given the pace and quality of scientists at Musk’s neuralink, I expect brain downloads before the century is out and be alive to then! Never mind the 512-year health span of sharks. Maybe, humanity will go beyond Dr. Sinclair and not do mTOR reduction methods.

A remarkable paradigm shift is in how to get end-less life!

1. Standby for fertile sci-fi imagination from me!