Science feb 2021 Puzzle
The COVID-19 pandemic has been puzzling to many public health experts because Africa has reported far fewer cases and deaths from COVID-19 than predicted. As of 22 November 2020, the continent of Africa, comprising 1.3 billion people, had recorded 2,070,953 cases of COVID-19 and 49,728 deaths (1)
AA take home
Moderna name is
from Modification to RNA – A brand-new technique that
revolutionizes slow illnesses like heart, Alzheimer etc and aging
(despite FDA, AA calls it a disease). Many vaccines are not just India (Dr. Sinclair family methods, plasma replacement) are one shot and not applicable to slow diseases like heart, cancer, Alzheimer, Parkinson etc and of course aging.
My guess solidifies!
It started from a chance observation of mother – COVID-19 is strange, every victim is in well-to-do class, none in laborers, small shopkeeper etc, despite the fact they practice frequent violation of COVID-19 rules! Look at damn Pakistani!
Immunity for whom?
My brain digested
this. Either it was food which gave them immunity or sun. Sun
sounded better as all above 35 parallel were hit hard! Example
were USA, Britain, Europe etc. What gave me big pause – darker the
skin, more was COVID-19 damage. Learned something magic few days ago –
vitamin D3 lack, very counter-intuitive, lack was proportional to
color of skin! Darker skins! The Point is that darker skin people avoid
sun, forced if poor! In the US, COVID-19 deaths are proportional to color of
skin! Apparently the out-of-work people get their dole and avoid sun!
And mind you, our group was inundated with Modi lack of wisdom re
fight with pandemic! We were wrong, letters? D3 is sun or ingested as
additive or supplement. High D3 is why President Trump flew in
Florida after corona discharge! And Pfizer sank him by refusing to
talk before elections! Strange science/engineering, reverse of climate change.
What next after ODF?
USA is smart, public
health people have forced fluoride in water and D3 in milk! Wish our
government did so. After ODF, when done, to the next step – no hand
contact and compulsory bidet system, skip paper step! Then water
floss, skip thread floss! Two public health steps to improve on the USA! In 50 years, India should surpass the USA!
Science Feb 2021 Puzzle solving.
Dr. Arun Arya
(heavily drawn from article https://www.bostonmagazine.com/health/2019/10/29/david-sinclair)
Age 60, I want to be, fuck FDA or medical doctors, Dr Sinclair enunciates pure science.
Thuggery?
From time immemorial, people have been on a fantastical quest for a substance that would extend life, or even grant immortality. The medieval alchemists sought the elixir of life. Explorer Ponce de Leon looked for the fountain of youth in what is now the southern United States but, in an ironic twist of fate, found Florida, a place where people go to grow old and die. As the centuries wore on, traffic in life-extending substances and practices became the clear bailiwick of snake-oil salesmen, charlatans, and quacks.
Justification
Needed first after above!
Justification to me? ( ALL disbelievers after this are stupid, don't bother me)
To go past rationally skeptic me (RS) you can not ever argue on bases of ancient tomes, human thoughts, human claims (no matter how much you trust), stupidly motivated methods or expensive methods, all considered subhuman. I consider all advertisements and politics, most philosophy and common knowledge stupid. All organized religions without exception are stupid. One must base any beliefs solely on scientific theories, which means axioms experimentally established to RS satisfaction. Today aging, life, universe, Intelligence are all establishable from scratch, without any religion. The Only reasonable way to dissent is to point to another falsifiable theory or make mine false! To call such material another religions is the height of stupidity meaning don't ever bother to converse with me, your free speech rights pale before the waste of my time!
I claim to know about extend life using Dr Sinclair Justification. First then how do I know how? How do I extend Dr. Sinclair more research? Can you, a reader, enjoy benefit, ie extend life? Help me? Every other article you have read in life so far means nothing (pales) beside this! Only read it properly after cursory skip read when have time!
Dr. Sinclair a fraud?
Unlikely, as a billionaire (from resveratol) and faculty member at Harvard, enunciates the theory. NASA has appointed him as chief doctor for health of first astronauts to Mars. And he is a rare scientist who talk simple and intelligent. Most important, unlike other scientists, he believes in the safety and efficacy of his works and applies it to himself, his father and brother, each of them claim to benefit! Billionaire means Not prone to advertisement subhumans. HE MEETS MY SKEPTICISM of temptation (billionaire), stupidity (Harvard) , hot air (Read up to compatibility with biology, evolution. physics, medicine), integrity (NASA), Self-application (New, discussed, skip FDA). I write this, open to answer ANY reader quesion or doubt, with the public statement I folklow him without quesion for my life and money. I am a departmenbt topper from IIT Kanpur at its prime and likely far more skeptical then you. I follow him blindly only for aging things and only his life does not need me!
Going beyond FDA is caused by realization that I need results now and also in next few years, without the delay caused by proper blinded-tests. Covid-19 innoculation was done within a year unlike all other vaccine because RNA medicines meant the test chemicals were availble within a week post analysis and testing took an year! Central to all is my notion of medicine, modern medicine is best for all short duration ailments (<= 1 Year, and useless for long duration illnesses of heart, diabetes, alzheimners, parkinson etc and aging! Problem is not the doctors, but the FDA test limitations. Mind you, FDA discipline defines modern medicine and doctors who deviate are subhuman. Short term events in long illnesses are also best done by mm.
Dr. Sinclair a dimwit?
Coming up with a theory consistent with medicine, biology and evolution, experimentally establishable, is hard; harder is being efficacious.
Dr Sinclair is wrong!
Possible but for two experiments, 2019 increase age of rat and december 2020 recreation of optic nerve after crushing it for mice. Both follow from his theory alone. Another indirect proof is failure of manipulation of length of telomere. Theory same for humans and mice! NMN helps animals and plants (personal experiment, nad+ direct).
There are other theories!
Only other one was based on telomere length.
Explanatory power!
No other theory can explain Darwinean evolution. The amazing theory not only consistent with aging but in all forms of life like trees, plants, animals and human. Point is that all forms of DNA based cellular life. No other DNA is known to exist.
There are other theories!
Only other recently debunked one based on length of telomere.
Consistent to!
The mechanism for DNA repair is consistent by orthogonality to all theories of DNA clock of Horvath and complete erasure of cellular specialization by Yamanaka factors.
Science considers aging forbidden territory!
Not so. Claim that recently, though, longevity has become the stuff of legitimate science. Sinclair is a superstar among a group of researchers who have harnessed science and technology’s latest advances in an effort to parse out, for the very first time, the biological mechanisms of aging in hopes of slowing or even reversing the process. The goal of this field is not to make us young for youth’s sake, but to address the single greatest risk factor for heart disease, cancer, diabetes, dementia, and many other forms of modern-day suffering: aging. Radical new theory says we can cure them all at once (instead of relying on the current Whack-a-Mole approach) and greatly increase the number of years people live with good health. It is also true, experts say, that eliminating all of these diseases of aging will make
long life.
Not a medical doctor even though professor at Harvard medical
Sinclair diligently points out that he is not a medical doctor; that he is not recommending anyone do what he does; and that there is no definitive evidence that any of it helps humans. Sinclair says he has nothing to do with the supplement industry, a claim that is mostly true.
Scientists (FDA approved) and Sinclair
A journalist went to an aging company. As they (senior escorts) took me back to their lab, I noticed the paunch on one of them, the wrinkles on the other, and the fact that what little hair either of them had left on their heads was somewhere between gray and white. I lowered my voice and asked, “So are you guys, you know, taking the stuff?” “Of course not. We are scientists!” one of them exclaimed, looking at me like I was the mad scientist in the room.
It doesn’t take a PhD to know that the fact that two guys who aren’t taking NMN look old proves absolutely nothing. But it did make me feel a little more hopeful to learn that they were not! And the funny thing is that later in the day, when I asked Sinclair why he takes unapproved drugs knowing that there could be risks (and how much it pisses people off), he said the very nearly same thing: “Itake them because I am a scientist.”
Then, he gave me another reason.
“And because I would like to outlive my enemies.”
Sinclair’s father and a Journalist
Finally, his father had his turn, dead-lifting 95 and then 115 pounds like it was nothing. The trainer told me most of his 80-year-old clients are working on maintaining their balance and lifting themselves out of chairs. Sinclair’s dad is killing it in the gym. His father has been taking NMN for two years, and since starting, Sinclair said, it has changed his life, his attitude, and his energy levels. It has returned to him his joie de vivre.
When I asked Sinclair’s dad directly “Can’t tell (re NMN),” he told me flatly, with a shrug. “But all my friends are dying or going downhill and I’m not.”Not only are Sinclair’s dad and wife taking NMN, but so are his two dogs. His younger brother grew gray hairs and developed wrinkles before he accused Sinclair of using him as a negative control in his little family experiment. Sinclair admits the thought did cross his mind, but blood is thicker than science, and now his brother is on the regimen, too.
Still, not everyone in the family wants to see people live forever. Sinclair’s oldest daughter doesn’t agree with his work and has zero qualms about letting her dad know it. She has asked him why, when previous generations have screwed up this planet so royally, he thinks it’s a good idea to have the people who did the damage hang around any longer. She is not the only one. Emory University bioethicist Paul Root Wolpe, for instance, has called the longevity field a narcissistic quest and points out that generational shifts are necessary for innovation, progress, and social change.
As if in response, Sinclair’s book has an end section in which he delves into many ways to fix the world he wants to create. There is, he argues, a solution to everything in a reality where people live to 150—overpopulation, inequality, natural-resource limitations—if you are as hopeful as he is. Just as I was finishing up this piece, in fact, scientists published a study linking optimism to longevity—meaning Sinclair could stand to add even more years to his life. Indeed, if I squint hard enough, I can practically see him growing younger before my very eyes.
I start by duplicating published cocktail taken by Dr. Sinclair. One crucial is NMN. Extracting aging related chemicals requires medicine knowledge. What grade of NMN to buy, where, how much, form i.e tablet, powder, solution etc are all medical matters. Dr Sinclair takes no OSKC yamanaka factors! Given that these must have genetic effects, FDA wait is required. What to then? For me and friends, wait is more deadly than side effects. I consider 90 without supplements and 105 otherwise. That is time enough for trials. They are needed, but must tradeoffs to benefits for age. Primary mixup needing a team of medical doctor and aging expert, of which I try to set up service. Horvath clock for bioage makes it a science. Intravenous better than sublingual or nasal drip; both better than NMN quaff (reason liver) but not needed for NR! NMN/resveratrol versus NR/pterostilbene requires empirical experiments, best done by enrollee costing! Even better may be NMN/pterostilbene, why say so?! Better than NAD+ direct (or NaDH). Why? Supplement guiding is needed and most medical doctors know nothing abut these molecules even, let apart know issues!
I know how
Ultimate proof to me is testing humans try it on themselves or close family if suffering! Not for any other ailment, every one is destined to grow old and suffer from age related diseases. Only way acceptable to scientific me, even FDA belief is too slow. M y lgowedge is from extensive read and self-experiment, want to make all next ones public transparent experimental.
How do I extend Dr. Sinclair - more research?
By making my bioage before and after my process public!
Can you, a reader, enjoy benefit, ie extend own life? Help me?
As referenced.
Why some prospered
Central to my thinking is rationalization of why USA prospered, as did Hitler Germany, Apartheid South Africa, Israel and China. While good in eyes of some, USA is micro-corrupt, as is Hitler Germany, Israel and China. So is India before Modi but faltering economy despite since then. No one knows the future, best estimate are forward market! I did some arithmetic, that showed me Forward rupee sinks 2.5% uniformly for next 5 years validated by projections 5 years ago when it depreciated 2.5%. So dollar is expected to be Rs. 85 in 2025. Despite fierce losses in Q1, Modi rate happens in Q3 and Q4. Q2 is tip of bad V.
In each case, the mechanism of markets is reward for innovation. That is so simple but profound. When its comes to external trade, you have no choice but submit to the innovator and buy the stuff! Consider military stuff. China has a huge submarine fleet. Per force, India has to buy 8i aircraft. Several other innovations from the USA, Russia, France and Israel. Pay in dollars for most. Despite being poor! Another is Soft innovation from Hollywood, publishers etc. There is magic Madison Avenue plays on undefined quality, but sane leadership can kill local and ads moronic, not done but simple, every ad subhuman will hate my prescription - can't run a single ad before paying for equal time to competitors! Total control without any management. Third huge area is drugs. YOU GOT TO PAY WHETHER POOR OR NOT.
West prospered despite every stupidity because they developed innovation through invention of patents. I claim that civilized version of laws, despite crushing of virtues, is essentially irrelevant. Virtues are NOT irrelevant because society-wide pursuit is never a prescription of decline. No matter what the ideology, political, social and religious etc - collectively ideologies and politicians leaders are essentially irrelevant. Not that they can make, but they can break. What matters ultimately is the reward structure. The society may be very corrupt - commie Russia, china, Africaan South Africa etc. In many ways, Singapore and UAE are ugly, yet they develop on. It is not just small states but china. Less corrupt societies develop, as can be seen comparing west, in every case it happened top down, and in each case, it declined by corruption at the top. My basic goal is to develop a system like patents and enclosure of the commons i.e. private property - these are not religious prescriptions but society chosen methods and perhaps amenable to societies. This is stark different from most existing ideologies and religions like nature has given rights etc. No ideology can aver that it is good because its axioms are self-evident - basis of all science is experimentation and (true false) lessons from not experimentable systems. To REQUIRE false observations as well is starkly different from most current social science whose predictions can be forgotten like sailers who saw divine worlds or believers in empirical post death experience or UFO abductors!
This approach is fundamental basis of my think. Any system that depends on human will be corrupt regardless, small amounts in the USA is fewer rules (liberty) and humorlessness! People have respect for law, but note small-time violation in New York City with abusive paint-can works and jumping tiles! It is NOT generic superiority but conditioned richer population, large number of well-off law-avoiders, but they call it freedom of lawyers! Ideal law is when violations are detected and punished automatically, by robots and computers. There is no fear of information misuse since guaranteed by proven security software. Missing that humans are used, but only then. The paid software rule is actually a corollary to general way more powerful idea that demand equal space and time for every copyrightable!
A far more powerful and just society results from identifying English/computerese correspeces compactly indicated by noun/object, abstract-noun/object, verb/operation, adjective/type, adverb/type, punctuation/meta object etc. Computer and human language can be the same, even internable through spoken translators that front end software solutions. Robot instructions can be built easily. In fact, my wisdom on insisting on Redmi 8 (now 9) is wise only because it has, unusually for mobiles, an in-built infrared which allows download of control software for TV, camera, ac, microwave, fan, lights today!
A whole slew of companies is built on innovation and prospered immensely by building on innovation from 1980 to 2010. Stage is now set for new crop built on innovation that will uproot and kill innovation last 30 year wave, ready to die as dependent on experience. Innovation kills the experienced! The higher level experienced try hard to save the less experienced but kill the company! Innovation worship implies a fish eat fish world without ethics.
The coming decade is going to be of mechanism operated by speech. Google and Amazon both have the guts of control of mechanisms. Time to build new mechanism with voice control. Robotics comes next - mind you translating speech into commands can be generic and fail-small companies. Forget stem cells! It will be of application of Yamanaka factors to all old-age diseases! Most Indians are not aware of that.
The kisan Andolan of today is so simple to understand - there are wealthy sons of Punjab and Haryana. The manipulated are farmers of rest of India. Every one is terrified of market mechanism which will allow market valuation of bulk produce. Non-contract as evaluated by market at sale time. Farmers of P & H can see the second green revolution happening. They want to kill all benefits for small farmers. There is a simple fix! Center gives MSP rights to states and choice to accept central laws or make their own. Emfubars all commies, congress and AAM aadmi. The P & H wealthy kisans will be hurt forcing their government to set proper MSP! It all depends on whether there is second green revolution. They are likely to be ruined by state MSP prices or the free market. They are likely to continue futile agitation. Furthermore, they CAN be law forced to allow traffic and be fully free to many year agitations. Be prepared to firings.
Fundament to science is falsifiability, ALL rest is junk Science answers Religious questions answered, no need to believe in junk henceforth!
Subsequent life of Universe
https://www.youtube.com/watch?v=uD4izuDMUQ
Story of earth and solar system
https://www.youtube.com/watch?v=NQ4CUw9RcuA
Life: evolution and aging
https://www.youtube.com/watch?v=9nXop2lLDa4
nonbeliever Arun Arya
Following is a collection of linearized slides. It is directed to healthy retired friends and acquaintances or those who can take early retirement. It believes that heathy aging till 130 years is possible today, each elongation year healthy. Existing age effects detrimental to health can be stopped today!
Not every one gets US citizenship, then returns to their roots and try at business startup. My reason likely matches yours – escape inevitable old age. The singlularity 0f 1+ year extension per year happens in next 50 years, reachable by me.
My contribution and required from all else
===================================
Me – money in full
All else – 1 month of toil without pay. Full current pay + 20% for any mutually accepted period thereafter.
Pay will come from money given by first patients.
Obviously no one will pay unless convinced got full benefits.
In any case, some percent of company given to new investors. 20% of amount to people who do not continue.
Startup partner bioage determination is free ($300-$500).
Why do it so
============
Every thuggery is based on paying cash to the thug.
No one will pay money to any one but close friend, known in person many years.
To lesser friends, people will contribute, risk time only. Every one will risk time if convinced! That requires upfront money to me.
Paying upfront stock will work if company succeeds.
If it does not work as expected then just a vacation trip to India and age data!
Every startup person likes the capital to last long time!
Other methods
==============
It is my claim that Dr. Sinclair has uniquely solved aging mechan ism and all others are subanimals.
Every other method is subhuman – regardless of experience, knowledge, prestige, fame of the purveyor. Dr. Sinclair is polite, I am not, they are thugs.
It is possible to objectively measure age benefits of any method, all the bastards can be caught, using Horvath clock, converting aging into science first time in 2019.
What is expected and why
======================
You must read and understand Dr. Sinclair of Harvard.
At this time, only Metformin 1gm, Acarbose, Resveratrol 1gm and NMN 1gm per day work.
NMN must be taken with betaine or vitamin B15.
NMN must be protected from liver. Eating it fails. Sublingual, nasal drops or iv. In iv form, 500Mg may suffice. NMN is expensive and 95% suppliers are subanimal criminals.
Iv is very hard unless a nurse – where you come in if a nurse. No iv solutions of NMN are sold or will. I know how to make it.
Expected of you
===============
If you know “not interested”, send me facebook mail with just “not interested"
If not interested but lazy, read book first etc, you will get official invite whenever.
If interested, read book first and decide afterwards. I do not promise another invite. I am going to do it anyway, possibly without a company. Will pay Indian nurse then.
Why start company
=================
Aging has unlimited patient supply.
Convincing proof is now possible by externally done bioage.
I believe hence will make self first victim.
Benefit happens in one month. If you are convinced, only then offer yourself as beneficiary.
USA doctors do it in Texas for $1000 per day. No one honestly working can afford it. Only startup persons.
What I bring to table
==================
Only thing that follows from here is something you can get by Reading Sinclair.The iv solutions of NMN are not sold!
Like NMN are benficial salts NR, NAD+, NADH.
Direct NAD+ is better foir ALZHEIMARS and other Brain disorders. So why NMN and not others. I know scientific reason (objective)!
Aging avoid very new. So much that5 FDA doesnot call Aging a disease, meaningless improvement!
Measuring benefits objectively
===========================
Salutatory bioage determination is by Horvath clock which measures methylation concentration of several thousand DNA points and reduces them to bioage.
Determination is human difference free (race, exercise etc). It works for all DNA life like trees and animals!
Bioage is 3.1 years within calendar age and predicts remaining life as well. Companies in USA do it. So measure before and after any procedure and any moron! You can know how old and years of life remaining! DNA comes from spit or blood lab.
making a business
=============-==
I am starting an Aging undo company. I think no doctors are taught about aging, in fact even FDA refuses to call Aging a disease. A dream since 5000 years came true in 2019.
10 years from now, aging will be called a disease and doctors will try to monopolise it. I will be there for grandfathering.
Horvath clock is NOT known in India but common in USA. Going to USA for measuring it is ridiculous.
India based measureing makes "Aging undo" a self-sustained idea. I take all money risk - it is my company. I belive in it and drugs and Horvath clock and will be the first user! The company is formed and run if its cost is 50 % of 1 year plan I will do regardless! I have money, time and will.
