Saturday, July 15, 2017

striped evolution - The engineers and the scientist


They are diametrically opposite! What follows is a remarkable thought by me on variable novelty that explains rise and fall of Vedic India, ancient Iran, ancient Egypt, ancient Greece, Rome etc, their downfall and the success today of Cubans in Miami, Indians and Chinese in silicon valley. Principle thesis is identification of the synthesis of scientific manager and his value but view businesses evolving by striped evolution similar to, but distinct from, punctuated evolution, the stripes being engineering and science.

Biggest learn from the essay is development of compensation mechanisms for the non-engineers essential for progress but largely failures.
Knowledge is the gold that oil was in the last century. Given any unfamiliar field, it can be posited that it will be a graph, largely dag like. It can be traversed depth first DFT or breath first BFT. DFT is chasing explanations till they are in the known language. BFT is understanding of the width of the field in terms of concepts not properly understood. To illustrate what I am talking about, I consider ageing research, surely of interest to all no matter how skeptic (quest easily goes back 5000 years, why now?). In order to proceed, I will prefer the engineer/manager/politician BFS, only deal with relevant science.

Relevancy sharply separates the engineer and scientist. The engineer seeks relevancy to the problem which must have an economic value. The scientist relevancy is only to solution of the problem at hand or in the field, independent of economic value. Per force, scientist is DFT while engineer/manager/politician if BFT.
The distinction is clear in related fields like music and cinema. There are a vast number of scientists that understand some aspects quite well DFT or somewhat of all  BFT, But there can only be a few winners! It matters not how competition works as long as it is largely genuine! There have to be good winners and losers who do their best to win but do not! Insecure immigrants are willing to work for low pay anjd hard to rise, as compared to locals. Only some immigrant are successful, but proportionally more than established. Novelty is not just good, but required to rise! Explains Cubans to silicon valley. Why else would large army of scientists be available at low pay? Because that is the only way forward!
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Chase of novelty is crucial to understand rise and fall of civilizations. Novelty seeking phase marks the rise, most novelties are counterproductive, but not all are and this is the only way to rise. Experience indicates that past proves the value of one sort of novelty which is self-defeating. Novelties are rarely good, only when they are usually good, the civilization rises. When most are unproductive, civilization suffers.
Enter the OIE who explain the glorious past in a contemptuous language utterly unsuitable for novelty!

USA history can be divided into phases in which certain innovations were useful to all, spreading by communities, tightly knit. Sub communities form, it explains sub castes and trade driven last names. The stature of the sub caste waxes and wanes.
To argue the relative importance of DFT and BFT is stupid.  Ideally, they proceed in parallel.  The conversion of science to engineering is timed process. Given that every engineering is basis of next science and vice versa, it follows that progression is exponential! Further, forward prediction is very hard! Only some fields are exponential, most others are not and very predictable.

Science proceeds by large pool of brights performing experiments  (playing art) under the mistaken assumption that they will succeed like the best. Engineering is far more equitable and benefits the class.


Tuesday, July 11, 2017

Plan for and experiments in coming old age


No matter what your current age, every one yearns for amortal life and refuses to experiment away immortality if at all possible. What follows is a plan and sequence of experiments to test the feasibility. That it may fail is irrelevant, that it is NOT fiction (science or fantasy) and fully devoid of religion, is very important. We purge every religion by ONLY allowing one kind of truth beyond scientifically possible – extrapolation, calling ANYONT who calls for faith to be criminal subhuman. All pseudoscientists are purged by requiring empirical verification, multiple known independent verifications, historical statistics and no experimental debunking research done whenever possible.
With these filters, only known research that passes is calorie-restriction, great for increasing lifespan, b but not quality of life! Uniformly what can increase QoL is increase in NAD+, involved in NADH-NAD+ cycle for charging the batteries for effort. Age is uniformly seen as life-long accumulation of cellular damage. There are two distinct orthogonal problems here – old ag- creep and accumulated tiredness or reduced QoL. 

I propose two different approaches – one for higher QoL to delay death too beyond expected singularity and mechanism of singularity. Singularity has easy non-bio definition – point beyond which expected remaining life per year is more than 1 year.

The QoL and marginal life increase is from metformin and niagen. Two rigorous studies have started on each. Niagen is modern way to increase NAD+. It works where diets fail and where reservetrol and Glutathione failed. Why diets fail is clear from minute amounts that diets provide. Where Reservetrol failed follows from touchiness of the molecule and bioavailability. Glutathione is bio-availability.

For any cellular process, the chemical must pass through stomach-blood barrier. There is further reduction in cell absorption even in blood. Glutathoine has additional property of disrupting melanin production. That is why, it can be used as skin-lightner by 2/3 world population, who can even be thugged by Glutathione soaps! One can buy and eat heavy expensive concentration of Glutathione for marginal improvements in skin-color for a few months. Enough to make tons of money in arranged-marriage cultures like Korea, Vietnam and India. Best effect is produced by glutathione administered by IV route, something expensively done in top Indian cities under doctor supervision.
Neither Glutathione or Reservetrol at this point are effective for NAD+. However, a form of vitamin B3 called NR is stable and has been sold for about a year by amazon and does not cause dangerous flushing like regular B3. Comments by users are available for abouyt 1 year use and are 50-50.
I have the unique ability on earth to finish may IBE and convert it to customer-comment studies. IBE is required to eliminate false testimony – for and against. No one but I can when done! Current
Plan for tests

There is no need for testing singularity chemicals or procedures. The software for secure-customer test of equipment is wonderful application of AAFIBER (Arun Arya Family Identity Based Encryption Restricted) which only I on earth can do!

Quickly, modular square root is a one way function – sqrt are crypt-impossible while squares are easy. A sender encrypts with any 1000-2000 bit key in recipient mod and publishes the square and encryption in that key. Only the intended receiver can get sqrt from me on the cloud and decode. Key enabling observation by me is that p*P*Q*Q has a square root of P*Q and not knowing P or Q, P*Q is crypt-impossible. Thus the recipient can make many secret keys from his P. No one knows how to do sqrt efficiently but me, even knowing the factors of the modulus. Different nations can know own factors, decode any allowed message but not of any other nation! Further, without decode of the message, a message can be checked if modulus allowed. Thus, without worry about corrupt police, or foreign spies, a nation can permit encryption without enabling the terrorist!

Every application of MY sqrt extraction is open source and no patentable application will be allowed as a condition of sqrt use on the cloud. Nice things about one-way is the ease of checking the answer – just square it! How it works is instructive since each enrolled customer is like an IoT device. As sellor, I am simply conducting a survey. The customer responses are also encrypted if desired by the customer and exposed only to readers satisfying some filter. In particular, some responses are compensated and analyzed statistically for usage studies. Drug responses are a particular application of product studies, in which doctor permission and re-patient-protocol are followed. NR is not restricted drug yet.


A complete product testing mechanism can be created by me that can compete with likes of consumer reports. It is particularly useful for investigating the effects of various supplements and ayurvedic or unani drugs and procedures. It is also useful to prove that homeopathy is a criminal enterprise where the patients are entitled to sue the treatment alleged.

Sunday, July 9, 2017

Us as gods




Thisreference has major religious significance to me, the innovator of and solebeliever in aaqgs-religion. While referenced and reported in very off-hand manner, it is of vital importance to me as it analyses the famous gedankan experiment of James Clerk Maxwell 150 years ago on the famed demon that could violate the second law of thermodynamics. Why-not is a celebrated question in physics. Turns out, any physical demon has to store some things in memory and no finite sized memory would work. So the brain has to be garbage collected andwill require more energy to do than the energy extracted! So second law isclassically safe!


Physicists read Maxwell's Demon's mind


Quantum mechanics is different. The deep analysis above makes the assumption that a gas particle is higher energy for one bin, or lower energy for other bin. Eventually, one bin is higher temperature than other and a classic heat engine can extract work. Problem is in quantum mechanics, you can have a third possibility – both higher and lower energy at the same time! What next is the thunder in the paper.



It is yet another gedanken experiment at this time, but who knows in next thousand years! Living that long happens at singularity expected in 2040 decade. Living that long is metformin and niagen, the safe anti-oxidant, hence age sustaining long life. Wow!

A future without fakes thanks to quantum technology





Scientists have created unique atomic-scale ID's based on the irregularities found in 2-D materials like graphene. On an atomic scale, quantum physics amplifies these irregularities, making it possible to 'fingerprint' them in simple electronic devices and optical tags.

Thursday, July 6, 2017

Unbelievable progress



http://aaqg-arunarya.blogspot.in/2017/07/unbelievable-progress.html

On some matters (To be replaced by similar talks, available as transcripts, with wiki level of references), to be extended into new subjects. Elimination of traditional social sciences, management and history as worshippers of false God. Banishment of the false scholars, extant religions and these false arts to nonsense sections of libraries. No tax support of false scholars or prophets.

The aaqgs religion exists to answer all without faith. Faith is considered to be a tool of the thug, only demanded by criminals and is uniformly replaced by extrapolation.

How does one feel dead? Extrapolate from dreamless sleep and pre-birth!
How did universe come to be? Geometry after big bang! Extrapolate from known astronomy and astrophysics!
Before that? Controversial because time may have a beginning!
Why the bang? To reset or start in low entropy!
What does entropy do? Eventually kill any system.
What is purpose of life? To procreate so that our distant children are victorious over entropy and become gods who live forever.

The unbelievable - not only metmorfin + niagen take you to singularity, a path exists for one kind of singularity to life span of few thousand years - distinct from hibernation; today I read of electrifying analysis of maxwell demon in quantum realm where for the first time in human history, a speculative trail to such a demon exists which defeat entropy, defeats the second law of thermodynamics, and extracts energy from identical temperature!

I donot have to have extraploratory belief in such successors but may be a candidate myself!!

Physicists read Maxwell's Demon's mind

Pioneering research offers a fascinating view into the inner workings of the mind of 'Maxwell's Demon', a famous thought experiment in physics

Date:
July 5, 2017
Source:
University of Exeter
Summary:
A fascinating view into the inner workings of the mind of 'Maxwell's Demon', a famous thought experiment in physics, has now been gained by new research.
Why is disciplined happy life necessary? Procreation is not just genetics but epigenetics too!
Why for most? No one knows whose genes and epigenetics critical in entropy wars.
Who not? Require too much (super-democratic) effort.
Why is crime bad idea, if no God? People like me exist who advocate supermajority distinction between forgivable and unforgivable crimes -also based on criminal history - and advocate extended life-preserving torture to the deemed-incurable unforgivable, even though opposed to death penalty, I am quite comfortable with torture for rest of natural life, age notwithstanding, of subhuman responsible most in Nirbhay case. The sub human’s lifelong torture would mean all the other criminals would be alive and in jail torture-free after serving the torture-periods. The Mumbai shooter would be alive being tortured every day! I have must-prosecute contempt to blanket opposes of torture in law enforcement.
Why extrapolation over faith? That is how I pick plumber, worker, doctors, friends, technician etc. Why not politicians, policemen too (at least to expert counters).

Tuesday, July 4, 2017

NRK1 enzyme and explanation of diverse results



Here are some probable reasons, derived from knowledge of criminals
1.       Either amazon or someone is spending money to feed bullshit reviews and clicks. Matters not id amazon indignantly denies it. I, and only a few people who can do IBE, can prevent vote and review fraud. Only I, on earth, can do it by square roots, not even the greats. The immediate advantage is that while sqrt is crypt-impossible, squaring is eas. Further ziillions (in fact 10^300+) of independent fields (trillions per user in population of trillions, quadrillion of devices for IoT etc). Not many can say this with confidence. Fortunately for me, click fraud and paid reviews are profitable and loved by neo-criminals. Fortunately for Sir Bezos, I a’int competing with him yet. This gives me a very powerful vulnerability.

2.       As I guessed based on perusal of reviews, those who find it works believe in it and exercise, middle ones are lazy, while tail enders are depressed!

3.       3. The dosages and minimum period varies. Every one did it there own way – AMA has not managed to get treatment declared to be doctor only ye! Best use seems to be varied dose based on energy needs.

4.       Age matters – elders luckily benefit most from the extra energy. The younger probably (certainly I think) are unfamiliar with enervation, won’t even see the extra enegy.
5.       Now this that requires real read – NRK1 enzyme.

Tempel et al

Abstract

The eukaryotic nicotinamide riboside kinase (Nrk) pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to nicotinamide adenine dinucleotide (NAD+) by phosphorylation and adenylylation. Crystal structures of human Nrk1 bound to nucleoside and nucleotide substrates and products revealed an enzyme structurally similar to Rossmann fold metabolite kinases and allowed the identification of active site residues, which were shown to be essential for human Nrk1 and Nrk2 activity in vivo. Although the structures account for the 500-fold discrimination between nicotinamide riboside and pyrimidine nucleosides, no enzyme feature was identified to recognize the distinctive carboxamide group of nicotinamide riboside. Indeed, nicotinic acid riboside is a specific substrate of human Nrk enzymes and is utilized in yeast in a novel biosynthetic pathway that depends on Nrk and NAD+ synthetase. Additionally, nicotinic acid riboside is utilized in vivo by Urh1, Pnp1, and Preiss-Handler salvage. Thus, crystal structures of Nrk1 led to the identification of new pathways to NAD+.
What does it mean in human English?
Based on yeast model, lifespan extends. NRK acitivty post nerve damage is enough to distinguish carboxamide.Human NRK induced novel paths toNAD+ synthesis in yeast! The reverse may be true – something like NRK is an effective add to NR supplementation.

A comment - However, when the company asked me my opinion of the product, I didn't include the dosage in each capsule. I think you could research that info for yourself. I followed the suggested daily amounts and found that the product sucked. Let me rephrase that, if it sucked that means the product did something. The product did NOTHING! I repeat don't waste your money. Cool?
Another comment -
I was on this for about 7-8 months. I am a 66 yr. old female and I still work full time as an accountant. Approx. 2 months ago I decided to go off of it due to the expense of Christmas, etc., and I had began taking Pteromax, a stilbene polyphenol complex by Biotiva. So I assumed that I probably didn't need to have both as they are both quite expensive.
Or –this –
..’

I am guessing that most of the folks reporting little or no benefit from NR are either younger & healthy and have plenty of NAD; or, perhaps are taking far more than they need, producing some sort of negative hormesis-like response; or are not taking complementary doses of resveratrol, or other pterostilbenes, which operate in tandem with NAD as a substrate to influence anti-aging sirtuins.

Fortunately, bad one very rare comment. Big question is dosage. Tested rats were given 24 md/kg wight. That’s nearly  1 – 2 gms per human per day. Some elderly hated the energy feel leading to quic exhaustion. They felt results even at 250 mg dose. Think enough to test – important point is nontoxic till 40 times, or 10 gms. Increase if any good/best way.

Fascinating thought


I consider drug companies to be criminal – they have no sane way to price a drug differently in different markets based on ability to pay, and hence indulge is perhaps-legal but I-consider criminal ways. Using my IBE, hopefully done by by IoT UK conference or may be next year (if NR works, so goes unholy fears in me of timing) then there is some sense in formalizing what I am doing and do continuous integrated  drug testing with sales. I think that more than average drug study is false (consider fat versus sweets versus diabetes), stevia etc, and loudly say that lawyers and judges are  non-participatory but responsible criminals  too. The fact is that ADA and AHA are responsible too unless they accept responsibility and change drastically.

Forward link to a relevant refining narrative


Sunday, July 2, 2017

Engineering in rejection of transplants

http://aaqg-arunarya.blogspot.in/2017/07/engineering-in-rejection-of-transplants.html
http://www.sciencealert.com/this-protein-could-explain-why-our-bodies-reject-transplanted-organs?perpetual=yes&limitstart=1

There are plenty of cadavers, and people willing to part with redundant safety organs, to provide many transplants if the problem of rejection can be safely overcome. Standard technique so far is to address the problems of rejection by depressing the immune system of the receiver enough to allow the transplant to merge with patient system enough that it is no longer considered foreign.
Buried in this narrative is science. The body has developed markers to differentiate friend protein from foe. Depression of the immune system opens the body to all opportunistic infections and cancers. That is solely because of friend/foe identification at protein level.  A type of receptor on bone marrow cells called signal regulatory protein alpha (SIRPĪ±) has been identified by scientists from the University of Pittsburgh as the body's watchdog responsible for dispatching the lymphocytes that target and destroy foreign cells. The mechanisms behind the white blood cell assault are fairly well understood – molecules on the outside of the cells belonging to what's called the major histocompatibility complex (MHC) identify them as different. A type of white blood cell called a T lymphocyte has receptors on its surface capable of recognizing unknown MHC proteins and responds by attempting to break up the foreign material they're attached to.
Lymphocytes aren't born knowing what's foreign and what's not; they need to be taught. Which is the job of another part of the immune system called a dendritic cell. Dendritic cells chew up foreign proteins and weave them into their own MHC before displaying them on their surface like a microscopic 'wanted' poster. They then migrate into the body's lymph nodes where they interact with the gun-slinging T lymphocytes.

A better match between the donor's and recipient's SIRPĪ± genes could help reduce the risk of the immune response being sparked in the first place. Like blood typing, MSC matching. Not yet, since still 1-10 or 1-20 chances’ of rejection, so have to immune-suppress all, to be on safe side. Will I take these odds? What are the odds of infection/cancer if immunosuppressed? When that happens, engineering starts!