Game of precursors

To feel energetic in old age, your nad+ must be high. Thereare de novo and salvage ways to nad+. Applies to ALL without exception or age now.

Why nad+?

It is part of the inner chargeable battery that cycles between nad+ and nadh.

Why not synthesize nadh directly?

There are no direct reactions of substance. Only nad+ can be increased, in turn food will charge it to increased nadh. Mind you, the energy recovery is by unit weight. So either nadh or nad+ has to be synthesized

Why increase nad+ by nature way?

At this point, nature is mimicked. Someday, some bio scientist-engineers will claim other ways of synthesis and their methods will have centuries of anti-cancer testing. Till then, the conservative safe way is to mimic nature!

How increase nad+ by nature way?

We can do it by examining the precursors in various organic reactions.  Also one must consider the amount delivered. We have to cross the stomach-blood barrier and then the chemical has to be ingested by the cell. Collectively we call the crossing the bioavailability.

Why hard?

The cheapest way to increase calcium is to eat chalk. Bad idea because the chemical may damage the stomach and has negligible bioavailability. Same is not true of some complex bio-molecules with Ca ion. Even the best have maximal absorption rates, so there is NO instantaneous way of raising!

How come you know re Ca?

My mother has been diagnosed deficient in Ca, fundamental cause of osteoporosis. Interesting ways to increase Ca makes sense to me!

How can you improve bioavailability of anything?

No matter what it is, element  ion or salt, you can always inject it into the blood stream directly. Problem is you bypass the stomach-blood filter that performs two essentials – keep out the impurities and convert it right blood form. It means that injectable be medical-grade pure and known to be injectable! An anti-oxidant Glutathione which also disrupts melanin synthesis has this property and slowly, doctors are opening direct-IV centers that advertise proven Skin-whitening for girl-marriage with guaranteed whitening for a few months.

Precursors?

There are many to nad+. They require 2 or more steps to become nad+. Further away you are, lower the effectiveness because of increased bio-availability issues and increased chances of unintended side effects. All start with vitamin B3, most have similar pathways to nad+ and similar bad side-effect profile – in other words safe to high doses . This makes them perfect  goods for semi-intelligents to be thugged in honest ways. Point is these are all precursors, they can each do the job, may or may not in reality, discovery is incredible hard, there are plenty of anecdotal-advice givers and wise-oracles buyable. In other words, intellectual debates best avoided. What can clear the nonsense are high quality studies, started for niagen in Japan and metformin in USA, but due in 2020. Even the need for such studies are a positive sign beyond amazon hype!

NR?

Nam, Na, and Trp (Tryptophan) are advertised, sold but shown ineffective precursors to nad+. Note that even earlier is B3 (niacin) in two forms, dangerous flushing niacin and non-flushing niacinamide. Another approach to non-flushing is time-release version of niacin. All these are as far away as B3 (First N in most is niacin). Much closer (closest) is NR. The riboside molecule seems to have better bio-availability for most in conjunction with exercise (I posit). Note that NR might be essential to motivate oldies  to exercise some, in the first place (past the feeling of enervation!). It is a good place to bet because Japanese are at least studying it! Best not bet but wait till 2018, but only if you can. It is NOT a shame to fall for amazon hype,  perhaps. At worst, very good chances are you wasted money at most.

Metformin?

CDC in USA studies it. Even more specialized studies operate. Early mother of investigations was a statistical study from 2000 + in UK that compared lifespans of metformin alone treated diabetics M, equivalent free of diabetes F and equivalent  insulin treated diabetics I; and found N – 5 > F > I + 5. Eating metformin seems to do the trick unless equivalency used by statisticians was bullshit! Started the study in 2016. A Swedish study pph-poohed renal damage, stating - Conclusions Metformin showed lower risk than insulin for CVD and all-cause mortality and slightly lower risk for all-cause mortality compared with other OHA, in these 51 675 patients followed for 4 years. Patients with renal impairment showed no increased risk of CVD, all-cause mortality or acidosis/serious infection. In clinical practice, the benefits of metformin use clearly outbalance the risk of severe side effects.

 How evil is sugars? VERY.

The United Kingdom Prospective Diabetes Study (UKPDS) set out to examine the effect of intensified glucose control upon the subsequent development of complications of diabetes in newly diagnosed patients, and the relative benefits of specific therapies (diet, sulfonylureas, metformin or insulin) in this regard. It recruited 5,102 patients from 23 centres between 1977 and 1991. Patients were followed for an average of 10 years. A blood pressure arm was added in the course of the study and compared rigorous vs less rigorous blood pressure control in hypertensive people with diabetes, and the relative benefits of an ACE inhibitor (captopril) or β-blocker (atenolol) in achieving this. Median HbA1c was 7.9% on conventional therapy and 7.0% on intensified therapy, and this was associated with a 25% reduction in the rates of retinopathy, nephropathy and (possibly) neuropathy. Results were even stronger in the epidemiological arm (which compared achieved HbA1c rather than treatment arm), and no glycaemic threshold for complications was observed. There was a non-significant 16% reduction in myocardial infarction or sudden death with intensified therapy, and a 25% reduction in the risk of death for every 1% drop in HbA1c. Antihypertensive therapy markedly reduced all end-points, microvascular as well as arterial.

WARNING: I AM no DOCTOR, nor are you. Get encouraged to visit and not appear stupid

Getting ambitious over needed anyway

A clinical doctor sees many patients and can learn from their experiences. However, there is a place for skeptics like me, since all their experiences are in cures attempted and diseases management as per their instruction. Whenever there is a major revolution in thinking, a skeptic, like me, has scope, but there are MANY like me. In overwhelming number of cases, the skeptic is the subhuman and wrong! So disagreement is not enough, else what and why? One has to understand difference between science and empiricism. EVERY person opposing empiricism is considered an emfubar criminal, ALL homeopath are like-criminals!

 One cannot dismiss Ayurveda remedies but safely dismiss large number of practioners! Can’t dismiss potions due to empiricism, can dismiss most practioners evidently not even aware of the damage noble metals like silver, gold or platinum may cause! Fortunately, as structured, drug companies are encouraged, even some times forced, to oppose inexpensive equally good plant sources of drugs. That means that CDC is not always consumer-friendly, especially when the fight involves large politically aware groups opposed to consumer good.

The shameful episode against stevia in the American legal system and escape from harsh penalties for smoking are bright examples. The vilification of Fats, not sugars and nonsense advice to control cholesterol is another example. Where does it end, or are ALL medical results suspect? There are friends who consider ALL so-called results to be contaminated! There are others who glorify anti-diets of yesterday diets! The best that diabetics can do is to eat fats! But wait a minute! Diabetes is from excess calorie. American teeth last a lifetime as opposed to Indian 60! Ain’t minority of doc consider increasing insulin deadly to a diabetic!

There is any easy rejoinder from me, one must never consider isolated results, or go to other extreme and only admit wholesome results. One must always consider diet and exercise as a required component of medication. I have encountered a gym instructor who considered himself to be a doctor and in fact cured majority of people who sought his advice ( and paid for it ). Point is that sample of seekers never included people ready to be hospitalized. But by personal experience, diet+exercise control has greatly helped drugs () which in turn has 

Getting it all together

Time to go beyond gmail, blogger and facebook.

1990 was a blow to me, fascinating because I cannot physically remember it. I remember a new beginning in the Boston rehabilitation unit. I learned how to brush and walk up three stairs in the physical therapy unit toy, not fall of the bed (I did, led to emergency visit and stiches). Wore a halo. In a few months, insurance ran out and I started on train every day to Lowell. I was diagnosed as TBI which means keep yourself very focused, ignore the voices, particularly those glorifying actions leading to suicide, or leading to it as the honorable necessity. It would be considered a crime by mother social security.

Twenty six years passed and I took stock. My father was mortally sick. Even my mother expected me to show some back bone. I had undergone twin eye operation, lost all of upper teeth, had to be on depaquote to fight headaches, had had 10 angioplasty, triple bypass and 4 stents, had questionable liver and kidneys, pained in legs, had bad soles and was a diabetic. Still cheerful because my parents had built a shell to protect me from real world which I viewed through Internet. I was very smart like Ancient Rishi – unify information skeptibly. The skill requires practice, the idea is to Haskell like unify to possibilities assuming that most narratives are honest but some parts, despite being strongly believed by the narrator are simply undefined!

Medical troubles all pointed to uniform disease mother – diabetes, reducing blood flow in many small arteries, hence the diseases. Sugar control became top priority – exercise and diet, religous weight control and gym visits. I have skipped medicine just once in last 10 years, and never gym, twice a day now, unless sick, even travelling. Every single physical disease has been crushed but not much progress in mental health. When will the ghosts leave me, stop acting scared of the world, or stop feeling cheated every time!

3 goals in 2016, urgent, were money, proper old age and respect. Answers were obvious – deep study of medicine but not as a cure for anything specific; aafiber (arun arya family identity based encryption restricted) for money and my religion like rishi for respect. As stoic, I could toil away happily for rest of my life on these.

One year later, I am amazed at the outline of what has beenachieved. Let us start by religion – important to me because I had no insanequestions but considered every person who answered eventually on faith or tomes tobe criminal. But then this

https://aaqg-arunarya.blogspot.in/2017/07/simplification-and-detailed-study-of.html

Not every day you wish to be attacked, but that would be a favor to me. The controversy between epicureans (hard atheists, most here) and stoics (agnostics) goes back 3000 years. A few weeks ago appeared the paper analyzed above which strengthens my agnosticism over atheism since while indefinite life was forbidden by classical physics; it was unscientific belief as per me. Quantum mechanics is different, one postulate and detail a Maxwell demon test! India had a long chain of Rishi who did not claim divine knowledge from relationship to any God, but fallible surmise from evidence. This happened in development of Veda, which became undeniable divinely revealed scriptures and imposed a 2000 year veil on India.

One can declare faith to be the tool of criminals and only accept extrapolation used by me to select plumber, doctor, friends and politicians. Every faith derived statement is bullshit derived! How does one feel dead? Extrapolate from pre birth and dreamless sleep! Amazing how many questions can be answered without questioning the sanity of the asker! That is what Rishi and Agnosticism is!

Second goal is money. What mother SS has spent on me so faris investment that has to be repaid! Is it possible for me to make money to thepoint that return is possible, even if torturous? Turns out on earth, only I know how to take square roots of 1000-2000 bit integers. I have developed a plan to make money from it! It can be used for hack-free communication of IoT objects upgraded by simple circuit to do multiplications mod integers.

Third and final wish is amortality – a nice long life withsmall diseased portions in the ends. I passed childhood with unknown but mother defined usual kid diseases. I have seen my father suffer, bad for celebrated disaster-in-chief of India, meritorious alumnus of University of Illinois and feted by UNO with recognition prize. What more can I do but make his last days better? Surely remove his pain and ten more years! If wishes were horses! But I believe that metformin, niagen, coQ10 and ECP extend life and improve old age! These would be expensive in US, but not in India! For one, physicians have not managed to restrict them. For another, they have nothing to say on how. All needed to get medical permission for father is tests on me. Neither have negative effects, except  metformin which may be taken by any diabetic.

Metformin operates not by releasing more insulin to kill excess sugar, but by restricting the sugar released. It is believed that excess insulin is BAD for you.

Your cells have 3 energy cycles, of which citric acid is uninteresting. Leaves ADP-ATP improved by coQ10 enzyme and nad+-nadh improved by flushing vitamin B3 or niagen.

ECP is giving the body another heart to improve blood flow in new arteries generated. ECP is vouched by flurry of chinese papers in top western journals (- the sales hype). Niagen has attracted rigorous japanese study, metformin US study. Only coQ10 has to fight customer reactions but is quietly prescribed! Problem is studies started 2016 and likely run 5 years. I need answers NOW.

Each of these 4 are low expense (low wage) country like India and may collectively be useful in improved energy feeling and 5-10 year extension in life. Worth it for father and certainly for mother and me.

Simplification and detailed study of Entropy-destroy paper

Never mind my deep claim to the centrality of this paper to physical immortality (as opposed to philosophical or literary, both avoiding how), it is first rate quantum mechanics from France and MIT-YALE. Let me see if I can condense the content top-down for Non-physicist audience.major:  Here is the paper. The consequences of the paper are realized to be major and deep skeptical analysis has begun. Exact details of construction of qubit and waste bath are included in the appendage to the paper, longer than the paper itself!

What the paper does is to construct a qubit in a cavity and pass a stream of photons through it which get separated by energy. In the process, entropy is generated passed to a waste bath of photons.

The system S is thus a transmon superconducting qubit 20 with energy difference ℎ"# = ℎ×7.09 GHz between its ground |+〉 and excited |-〉 states. It is embedded in a microwave cavity, the demon D, that resonates at ". = 7.91 GHz. The dispersive Hamiltonian reads 0 = ℎ"# - 〈-|# + ℎ".343 − ℎ6343|-〉〈-|#, where 3 is the annihilation operator of a photon in the cavity.

The clever part of the paper is exact changes in the entropy waste system. If done in the classical way, the Landauer's principle applies and the energy spent in forgetting exceeds the energy extracted.

 

This 1960 paper laid to rest Maxwell's 2nd law defeating demon after 85 years!

Situation is different in QM. Superposition of low and high energy states are also possible (at same time). What happens if they are used to discard the entropy? Some will become high energy. But some will remain as before, the entropic energy is absorbed and goes away without change in state! Such particles can be used again! The entropy has indeed disappeared without trace!

 

The paper is very technical indeed and describes an experiment that can be performed. But what is the hurry? It is pointless to worry about measuring theexact details of anti-fragility before solving the problem of thousand yearlife! That is what aaqgs-religion is about!

I am a stoic. Perhaps the Un iverse never had a start! The contraction phase of previous edition crunched down to generate quantum high-low energies same time! Such particles will eat up all the entropy and the next edition would start again with big bang with low entropy, recreating editions till the final one had so much dark-energy that it expanded forever. Like us!

And the emakable joy of reaching this conclusion indepen of, and different reasoning, from the

Conformal cyclic cosmology model of the great  Roger Penrose but different in that current creation may be the last!

What us gods can do

First you have to understand why and how we can live to become gods. Then one has to understand why and how entropy can be reversed – that is the only thing that requires a finite life, no matter how long.

The brings me to a latest idea in theoretical physics, likely to become ironclad in first thousand years, namely why time never reverses despite all physical laws being time symmetric. Turns out the second law of thermodynamics ensures forward progression but that fails to explain time-modifications with speed, so it’s like more than 2^nd law. Someone added black energy to the mix and believes that one direction of time has to do with dark energy, consistent far more. Not only can gods live forever, but they can even time-travel!

striped evolution - The engineers and the scientist

They are diametrically opposite! What follows is a remarkable thought by me on variable novelty that explains rise and fall of Vedic India, ancient Iran, ancient Egypt, ancient Greece, Rome etc, their downfall and the success today of Cubans in Miami, Indians and Chinese in silicon valley. Principle thesis is identification of the synthesis of scientific manager and his value but view businesses evolving by striped evolution similar to, but distinct from, punctuated evolution, the stripes being engineering and science.

Biggest learn from the essay is development of compensation mechanisms for the non-engineers essential for progress but largely failures.

Knowledge is the gold that oil was in the last century. Given any unfamiliar field, it can be posited that it will be a graph, largely dag like. It can be traversed depth first DFT or breath first BFT. DFT is chasing explanations till they are in the known language. BFT is understanding of the width of the field in terms of concepts not properly understood. To illustrate what I am talking about, I consider ageing research, surely of interest to all no matter how skeptic (quest easily goes back 5000 years, why now?). In order to proceed, I will prefer the engineer/manager/politician BFS, only deal with relevant science.

Relevancy sharply separates the engineer and scientist. The engineer seeks relevancy to the problem which must have an economic value. The scientist relevancy is only to solution of the problem at hand or in the field, independent of economic value. Per force, scientist is DFT while engineer/manager/politician if BFT.

The distinction is clear in related fields like music and cinema. There are a vast number of scientists that understand some aspects quite well DFT or somewhat of all  BFT, But there can only be a few winners! It matters not how competition works as long as it is largely genuine! There have to be good winners and losers who do their best to win but do not! Insecure immigrants are willing to work for low pay anjd hard to rise, as compared to locals. Only some immigrant are successful, but proportionally more than established. Novelty is not just good, but required to rise! Explains Cubans to silicon valley. Why else would large army of scientists be available at low pay? Because that is the only way forward!

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Chase of novelty is crucial to understand rise and fall of civilizations. Novelty seeking phase marks the rise, most novelties are counterproductive, but not all are and this is the only way to rise. Experience indicates that past proves the value of one sort of novelty which is self-defeating. Novelties are rarely good, only when they are usually good, the civilization rises. When most are unproductive, civilization suffers.

Enter the OIE who explain the glorious past in a contemptuous language utterly unsuitable for novelty!

USA history can be divided into phases in which certain innovations were useful to all, spreading by communities, tightly knit. Sub communities form, it explains sub castes and trade driven last names. The stature of the sub caste waxes and wanes.

To argue the relative importance of DFT and BFT is stupid.  Ideally, they proceed in parallel.  The conversion of science to engineering is timed process. Given that every engineering is basis of next science and vice versa, it follows that progression is exponential! Further, forward prediction is very hard! Only some fields are exponential, most others are not and very predictable.

Science proceeds by large pool of brights performing experiments  (playing art) under the mistaken assumption that they will succeed like the best. Engineering is far more equitable and benefits the class.