population age structure https://youtu.be/2EvYU-HmsvI
After 7 years post, 2015 Full time devoted to the study of Aging and deep analysis of science to unpack empiricism and scholarship, I am ready to announce that I have a new latest superior theory and a solid strategy for its undoing. I know that the undo part is correct since it is validated, though not FDA-empirically, by self-application and almost 1000 patients over six years by
He is believed by me for just 1 reason, he has used the prescription on himself and patients (700-1000) for six years and has glowing reports ( He is now 78, started 72, felt good after 3 months). Other than self-application, he considers mathematicians and computer scientists, not biologists and doctors, far more suited to Aging! What a miraculous find for me!
Everyone else who can not prove me wrong, including courts, police, etc, and particularly doctors - go to hell! I try it on myself - here or abroad. I will continue with doctors who believe me, to launch aging therapy on the side, with immediate singularity1.0 objectives.
My theory is the compositional theory of Aging - collects various theories of aging as being right at the same time as tested by DNAm clocks, and reflects the aging of different body systems, from 3 broad classes being top-down programmed built around halting mTOR effects, bottom-up around Yamanaka factors and healthy adversity as dietary restriction, and telomere extension based using intermittent hyperbaric oxygen. I believe on theoretic grounds that top-down mTOR methods and bottom-up Yamanaka methods can be reused multiple times and will have much higher priority. Telomere extension will be rarely material.
Hyper function aging - Who ordered human aging (other than a fuckedup god)
https://youtu.be/hyXH_m5a3NE
Understanding the Evolution of Aging in Humans: Aging is one of the great accomplishments in Biology. Among vertebrates; fish, amphibians, and reptiles have negligible senescence NS. The problem with NS is animals can figure out how to live too long. This is a problem in a changing world and makes it difficult to evolve new traits because breeding and the genetic pool are then dominated by older and bigger animals within the species, particularly food chain champions. This problem was solved by the newly arrived mammals some 180 million years ago. The solution was pure mathematics. Animals would grow up fast, reproduce for a few generations and then die. The pruning effect of the death of older animals would provide space for the new generation to thrive and have the potential to introduce favorable genetic variations. The problem was animals had become too good at figuring out how to live a very long time. The solution was a poison pill built into the genetic code. The animals with the poison pill would suddenly start aging and die. The animals without the poison pill would live longer and only suffer stochastic death or non-aging-related death. 180 million years later the winner is clear. All terrestrial mammals chose senescent and programmed death. Over the past, 180 million years fish, reptiles, and amphibians have remained negligible senescent and done reasonably well. However, they have not changed very much; while mammals have made extraordinary advances.
Understanding aging is easy if your field is pure mathematics or computer programs; however, it seems to be nearly impossible if your field is Biology. Unfortunately, aging theory was developed by Biologist and not Mathematicians or Computer programmers and the Biologist got it totally wrong. Today, an aging theory is dominated by a field that calls itself, "Biology of Aging". Their theory is that aging has no value, no genes promote aging, and aging in humans is essentially the same as aging in inanimate objects, like an old shoe or an old car. In short, the aging theory went down a rabbit hole.
To understand aging; compare a 100-year-old crocodile with a 100-year-old human. The 100-year-old crocodile is an extremely robust animal; bigger and stronger than the fifty-year-old crocodile, showing no signs of aging. This is in sharp contrast to a hundred-year-old human. Terrestrial mammals, including humans, are senescent animals while reptiles, like crocodiles, show negligible senescence NS.
Senescence is an intentional death program using programmed aging. The plan is to make mammals deteriorate and die. This creates more space for the new generation. The idea is that the new generation may have new genetic improvements and the goal of aging is to remove the older animals so their genes do not dominate the genetic pool. It is all a grand plan to develop genetic improvements. The plan is pure mathematics. Animals not highly successful in the development of genetic improvements over the ages became extinct.
Aging is a way to give animals a relatively fixed life span and then prune them. Aging Is the secret to the success of terrestrial mammals. A poison pill in the plan for genetic improvement.
Forewarned is forearmed. Once you know your body is running an ancient genetic program to kill you; then you have a chance to turn off the death program. Successful anti-aging medicine is about the discovery of pro-aging programs and finding ways to block these programs. The chief culprit is mTOR, particularly mTOR2. All non-critical aging chemicals have an important role - even reducing the main aging has some effects and legacy effects that may not rise to critical but are still implicated in health decline. thus compositional aging means all factors need to be addressed, only duplicated effect producers can be ignored
What is science?
Ultimately. operable definition of science is scholarship constrained to empiricism alone. Pure objective empiricism is NOT science as a collection of chosen unrelated facts is pseudoscience! 99% of well-adjusted viewed intelligent engineers have zero offering in non-specialization orthogonal subjects. I know it well from watching my father who was number 1 in disaster topics but very poor in business subjects, most products, and politics.
A theory becomes science when it correctly predicts an easy-to-see orthogonal subject. As a computer scientist, I add a clever requirement to usual philosophical points, the predicted phenomenon must be a non-polynomial extrapolation to all data used. An interpolation point result can be obtained by standard numerical science methods.
Science must be refutable! It must be empirical. My claim to "LATEST NEW SUPERIOR THEORY and UNDO OF AGING" must be empirically established. Till then, it is a theory, better than all others with documented applications.
Why computer science?
I have no reason advanced by the Good doctor. I state things that are to difficult answer by biologists and chemical scientists. How can one answer completion questions? In other words, collect all methods that are likely to result in bio-age reversal and more important determine the consequences of repeated use of age reversal.
singularity?
For my purposes, I consider Singularity in 4 parts. Everyone is likely to undergo all of them,
Singularity1.0 is an extension of healthspan without the necessary increase in lifespan. There are many reasons for it including the reduction in the severity of chronic age-related chronic diseases and survival to singularity2.0 to enjoy their benefits. It has started, and singularity2.0 is expected to arrive by 2030.
Singularity2.0 is proven to increase a healthy lifespan. Since life-span increases, the singularity3.0 is the point to which the extension is needed. It is likely that singularity3.0 arrive by 2050. There are 8 years to singulrity2.0, all the methods needed are available in the non-proven form, and enough josh is available to reduce the costs of therapies for use by limited-corrupt or advanced states.
Critical to my thinking are societies like India. The fact that India was biological backwaters to 2 years back, but developed vaccines, their huge production, and distribution, speaks volumes about limited corruption, excellent politics, enormous intellectual energy, and advancing commerce. In India, we have, in mythology, the dream of a Ram-Rajya. I have no doubt in my mind that Modi-Yogi will lead to the first Modi-Yogi Rajya which provides the first life, free of the horrors of chronic diseases, and an extended healthy lifespan. There is no doubt in my mind that they will become as central to Indian culture as Ram-Rajya.
Singularity3.0 is expected in 2050. By definition, it will provide a healthy life extension of 1+ years per year for 500 years. You will still die from accidents and murder, but not from senescence. It is not too much to ask since there exist animals without senescence for this goal and trees that live 5000 years. That lifespan is possible for a normally not-unlucky careful person.
Singularity4.0 happens 500 years when brain-download becomes possible. Accident and crime deaths are eliminated then by brain download and redundancy safety. Assuming limited natural effects, one can live for trillions of years and roam the universe without travel boredom despite light-speed limits since traveling photons do not feel the path, and time increment is zero for them!
Singularity5.0 happens trillions of years later. Some smart Ph.D. theses will collectively lay the foundation for exiting the current universe and going anywhere in the multiverse.
Algorithms can solve a problem in top-down or bottom-up manners, like a manager or a scientist. The problem of aging can be understood by top-down hyperfunction, or bottom-up DNA fix errors reduction. From our viewpoint, a body is made up of trillions of identical cells specialized to current existence by folding and unfolds of the DNA.
As time passes, errors in DNA show up in mRNA or the cell even forgets what it is. Either case, it turns senescent and a source of further problems. Cells have other communications too, like commands from exosomes or secretions of hormones. These are in addition to blood-derived chemicals from near neighbors. The exosome makes the sender behave like a hormone production organ. Top-down E5 likely improves stem cells for building senescent cells using exosomes to restart youth-like stem cells frozen from lack of orders.
What is death?
Death is a cessation of function. It is easily understood by analogy with a car going to a destination. After the setup is done, the car goes into a freeway and can drive fast. Near the destination, it exits the freeway to normal speeds. But bio-systems do not reduce speed. The car travels normal roads at a bad speed and winds up dead in an accident. Meanwhile, the car rusts. In most cases, it is totaled. In rare cases, rust gets it eventually. we can draw multiple lines under the process of transport. Disruption can occur in transport due to one of many causes, each with a probability that is itself a function of time, For a car is totaled with about the same speed but rusting death becomes more probable with time. One proof is the nearly constant annual probability of death from all causes past 80.
Unlike Sirutin, AMPk, and igf-1, which reduce aging on a boost, mTOR increases aging and is boosted by every boost in technological evolution. All good modernities cause accelerated aging. They include better food, better communication, screened devices, time savers, you name any modernity and it increases aging, To improve aging, you must fast repeatedly, joint ice-water/steam bath, whole morning shirtless bare chest walk in snow mountain, etc. Healthy adversity is good.
What is hyperfunction solution - 6mg rapamycin every week once. Controls mTOR, has no FDA test yet, can't be wrong given Dr, Green, stupid for all without being his patient, can choose an MD by clicking on the link when there. I suggest boosting Sirutins and AMPk on the side and doing singularity1.0 also. All the other steps are from Dr. Sinclair and ensure health bottom up even as hyperfunction ensures mTOR!
Composition of methods?
There are many processes of Aging. They are all progressing in parallel. One can divide the aging undo methods into 3 classes -
1. small increment in lifespan but larger in healthspan. These include boosts. senolytics. Kennedy. Fahy.
2. some increments in lifespan but substantial healthspan, a limited small number of reuses. Senolytics. Sirtuin and AMPK boost.
#1 is good for singlarity1.0 #2 is good for singularity1/2, and #3 is good for singularity 1/2/3. Being healthy old requires lesser aging fixes, so start early in all methods.
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