Saturday, August 5, 2017

Why this link

A reader may wonder at the self-aggrandizement represented by including a link to self in the document. It is not so, the stories are copied verbatim by me to send and also by readers to keep the copy when examined.

But the story might (often) changes after the copied alternative! The latest copy can always be referenced from the link included with the article.

More on Niagen


(1 year later) Nad+ is the goal, NMN is 1step away, avoids NAMPT bottleneck, Niagen is two steps away - A form of Vitamin B3. But NMN is 1.5 times more expensive.

http://aaqg-arunarya.blogspot.in/2017/08/more-on-niagen.html why this link?

This is a patent protected nutraceutical, all its commercial forms are derived from chromadex niagen, and hence quality difference is from additional chemicals and interactions.

Niagen boosts NAD+. What's that?

xidative stress and decreased DNA damage repair in vertebrates increase with age also due to lowered cellular NAD+. NAD+ depletion may play a major role in the aging process at the cellular level by limiting (1) energy production, (2) DNA repair, and (3) genomic signaling. In this study, we hypothesize that it is not NAD+ as a cofactor in redox reactions and coenzyme in metabolic processes that has the ultimate role in aging, but rather the role of NAD+ in cellular signaling when used as substrate for sirtuins (SIRT1-7 in mammals) and PARPs [Poly(ADP-ribose) polymerases]. Both sirtuins and PARPs influence many transcription factors and can affect gene expression. As a signaling molecule, NAD+ is consumed in the reaction donating ADP-ribose and releasing nicotinamide (NAM) as a by-product. It seems that aging at the cellular level is associated with a decline of NAD+ and that NAD+ restoration can reverse phenotypes of aging by inducing cellular repair and stress resistance. Adequate intracellular NAD+ concentrations may be an important longevity assurance factor, while lowered cellular NAD+ concentration may negatively influence the life span.

What is the state of niagen as per FDA?



Why should anyone believe Niagen?

1.     Ultimate proof is empirical, a Japanese study started in 2016, how will anyone prove anti-aging?

2.     Cells have NaDH – NAD+ cycle. One can show empirically that NAD+ level FALL directly vary with age and tiredness correlated with age.

3.     Eating Niagen provably boosts the level of NAD+ by empirical standard measures.

4.     Anecdotally, consumers feel better. A dosage level of 250 mg has been set by informal studies (larger doses do not raise NAD+ SIGNIFICANTLY before fall to 250 mg level).

5.     It is very expensive, far more than coQ10. Cheapest reliable I could find was at amazon,  at Rs. 6913 (when link taken) per month! It is not likely to fall. I see a battle-royal on drug patents by 2020!

Some more references?
What makes cells age? Wear and tear, yes. But biologically, says, Dr. David Sinclair, professor of genetics at Harvard Medical School, it’s lack of oxygen that signals cells that it’s their time to go. Without oxygen, the energy engines known as the mitochondria become less efficient at turning physiological fuel like glucose into the energy that the cells need to function. Eventually, they shut down…
ChromaDex Lead Ingredient NIAGEN® Nicotinamide Riboside Receives New Dietary Ingredient (NDI) Status From the FDA
November 16, 2015
IRVINE, Calif.Nov. 16, 2015 (GLOBE NEWSWIRE) -- ChromaDex Corp. (OTCQX:CDXC), an innovator of proprietary health, wellness and nutritional ingredients that creates science-based solutions for dietary supplement, food and beverage, skin care, sports nutrition, and pharmaceutical products announced today it has received New Dietary Ingredient (NDI) status from the FDA for its patented and proprietary lead ingredient, NIAGEN® nicotinamide riboside….

Dose-Dependent Elevation of the Blood NAD Metabolome by NR in Healthy Human Beings: Clinical Efficacy and Novel Diagnostic Biomarkers Abstract Nicotinamide riboside chloride (NR) is in wide use as an orally available NAD precursor vitamin. Here we conducted three experiments to determine the time and dose-dependent effects of NR on blood and liver NAD metabolomes in people and in mice, respectively. We report that human blood cell NAD+ can rise as much as 2.7-fold with a single dose of NR, that NR elevates mouse hepatic NAD+ with distinct and superior kinetics to those of Charles Brenner1 , Samuel AJ Trammell1 , Mark S Schmidt1 , Benjamin J Weidemann1 , Philip Redpath2 , Marie E Migaud2 , Frank Jaksch3 & Ryan W Dellinger3 University of Iowa, USA1; Queens University Belfast, Northern Ireland2 and ChromaDex, Inc, USA3 NAD+ Biosynthesis Study Design Phase: Day: -14 1 2 8 9 15 16 Visit: 1 2 3 4 5 6 7 2 Weeks Screening Treatment Period (3 Weeks) 7 Day Washout 7 Day Washout NAD metabolites undergo circadian oscillation(2,3). To eliminate circadian oscillation as an experimental confounder, we developed an oral gavage protocol in which male C57BL/6 mice were given single oral doses of NR at 185 mg/kg 20’, 1 hr, 2 hr, 4 hr, 6 hr, 8 hr and 12 hr prior to sacrifice, which was always performed at ~ 2 pm. In addition, mice were dosed with equimole amounts of NA, Nam and a control saline solution, and mice were sacrificed at 2 pm without gavage.
supplementationJ Neurosci. 2006 Aug 16;26(33):8484-91 (click to download)
4.   
Calorie restriction extends lifespan in organisms ranging from yeast to mammals. In yeast, the SIR2 gene mediates the life-extending effects of calorie restriction. Here we show that the mammalian SIR2orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie restriction in mammals; that is, fat mobilization in white adipocytes. Upon food withdrawal Sirt1 protein binds to and represses genes controlled by the fat regulator PPAR-γ (peroxisome proliferator-activated receptor-γ), including genes mediating fat storage. Sirt1 represses PPAR-γ by docking with its cofactors NCoR (nuclear receptor co-repressor) and SMRT (silencing mediator of retinoid and thyroid hormone receptors). Mobilization of fatty acids from white adipocytes upon fasting is compromised in Sirt1+/− mice. Repression of PPAR-γ by Sirt1 is also evident in 3T3-L1 adipocytes, where overexpression of Sirt1 attenuates adipogenesis, and RNA interference of Sirt1 enhances it. In differentiated fat cells, upregulation of Sirt1 triggers lipolysis and loss of fat. As a reduction in fat is sufficient to extend murine lifespan, our results provide a possible molecular pathway connecting calorie restriction to life extension in mammals.

Oxidative stress and decreased DNA damage repair in vertebrates increase with age also due to lowered cellular NAD+. NAD+ depletion may play a major role in the aging process at the cellular level by limiting (1) energy production, (2) DNA repair, and (3) genomic signaling. In this study, we hypothesize that it is not NAD+ as a cofactor in redox reactions and coenzyme in metabolic processes that has the ultimate role in aging, but rather the role of NAD+ in cellular signaling when used as substrate for sirtuins (SIRT1-7 in mammals) and PARPs [Poly(ADP-ribose) polymerases]. Both sirtuins and PARPs influence many transcription factors and can affect gene expression. As a signaling molecule, NAD+ is consumed in the reaction donating ADP-ribose and releasing nicotinamide (NAM) as a by-product. It seems that aging at the cellular level is associated with a decline of NAD+ and that NAD+ restoration can reverse phenotypes of aging by inducing cellular repair and stress resistance. Adequate intracellular NAD+ concentrations may be an important longevity assurance factor, while lowered cellular NAD+ concentration may negatively influence the life span.



Monday, July 31, 2017

Arya prediction – 21 century communication


Los Alamos National Laboratory has produced the first known material capable of single-photon emission at room temperature and at telecommunications wavelengths. These carbon nanotube quantum light emitters may be important for optically-based quantum information processing and information security, while also being of significant interest for ultrasensitive sensing, metrology and imaging needs and as photon sources for fundamental advances in quantum optics studies.

Read more at: 
https://phys.org/news/2017-07-single-photon-emitter-quantum-info-processing.html#jCp

Why century 21?

In optical communication, critical information ranging from a credit card number to national security data is transmitted in streams of laser pulses. However, the information transmitted in this manner can be stolen by splitting out a few photons (the quantum of light) of the laser pulse. This type of eavesdropping could be prevented by encoding bits of information on quantum mechanical states (e.g. polarization state) of single photons. The ability to generate single photons on demand holds the key to realization of such a communication scheme

Read more at: 
https://phys.org/news/2015-09-nanotubes-path-quantum-technologies.html#jCp

Why the prediction?  

Ideally, a single photon emitter will provide both room-temperature operation and emission at telecom wavelengths, but this has remained an elusive goal. Up to now, materials that could act as single photon emitters in these wavelengths had to be cooled to liquid helium temperatures, rendering them much less useful for ultimate applications or scientific purposes

How done?

Force the nanotube to emit light from a single point along a nanotube, only at a defect site. The key was to limit defect levels to one per tube. One tube, one defect, one photon. . . . By emitting light only one photon at a time, one can then control the photons' quantum properties for storage, manipulation and transmission of information. Wavelength controlled by carrying tube diameter, you can make different frequency elements. Change it dynamically – tunable room temperature single photon emitter is next step. Also doable by dynamic pinching of many tubes in parallel. Hence the prediction.

How built?

This degree of control using diazonium-based chemistry, a process they used to bind an organic molecule to the nanotube's surface to serve as the defect. The diazonium reaction chemistry allowed a controllable introduction of benzene-based defects with reduced sensitivity to natural fluctuations in the surrounding environment. Importantly, the versatility of the diazonium chemistry also permitted the researchers to access the inherent tunability of nanotube emission wavelengths.

Sunday, July 30, 2017

Aging, the aaquantum approach

http://aaqg-arunarya.blogspot.in/2017/07/aging-aaquantum-approach.html


The solution is NOT just follow the doctors (great acute, poor chronic), all they end up doing is delay death and replace the cause of death! It became heart disease and cancer last century. It will be Parkinson and Alzheimer this century. And mind you, the genetic causes will still lead to variations in life-span, just the valuable gene sets will change!

Aaquantum-I have read lot and believe I am ready with an integrated solution as trial balloon. Not only are ALL religious considered to be criminals, MOST anti-aging eminences are considered to be fools for not understanding the opening paragraph. Ultimately, the only thing that counts is empirical demonstration.

All my recommendations are speculative generalization extrapolations of established experiments to watch and support. It is very important to enlarge the case set of methods to introduce better atoms.
The method I seek is to move to a singularity in 2040’s to thousand year life, to extension using non-biological bodies. This extension is not relevant to first singularity – good luck to those who think otherwise.

The first singularity requires extension in age to between ninety and a hundred for me, doable with existing methods. The point is whether this range is likely and if the awaited singularity occurs.
Approach – Only five things are needed and can be and have been already incorporated or planned. These are niagen, coQ10, metformin, rapamycin and ECP. Beyond that is wittig-like reaction on niagen to make mitoq equivalent. No matter what my genes I think that religious attachment to exercise and blood-rotation will see me through with these. I have talked enough, documentation available on all others but blood-rotation, discussed briefly here, and great detail later. So the two points, beyond rapamycin,  are awaited-singularity and blood-rotation.

Blood-rotation: The experiment that drives this is effect ofsurgical joining of circulatory systems of two mice, one old and one young. The age symptoms of the old mouse disappeared. Scientists have already started to devise human tests in ethical manner (young ages!). What a gold-mine of tech fi stories I can write! The low cost development model does not benefit from centralization.

The rejuvenating effects are seen when lab mice are joined together in a rather gruesome procedure called parabiosis. That involves making cuts in the skin of two animals, then suturing them together at the site of the wound. As the cuts heal, the pair’s blood vessels will grow together and merge. The result is two animals that share a circulatory system, with both hearts pumping both sets of blood around both bodies. Doing this with an old mouse and a young mouse has some spectacular effects. As with humans, old mice have a harder time healing from injuries. But link an old mouse to a young one and it becomes able to repair muscle injuries nearly as well as its younger counterpart. Similar benefits are seen in liver cells and the nervous system. And it works in reverse, too: old blood can have a decrepifying effect on the young. 

Awaited-singularity: Some trees live 4000 years! Whathappens is that stem cells are placed in circulation by roots and reach theparts where cells divide. Not great accuracy is needed – if the division cellis poor, the stem cell progeny lives. It won’t work for humans because the pluripotent stem cell has already specialized. However, iPS cells can be specialized and injected in various organs. One consequence will be fight against cancer! There is hence a well-funded development trajectory.

para added in late aug 2017 - time to celebrate "I told you so!" Transfection is how tree-like life extension will go to defeat cancers.

Saturday, July 29, 2017

On the history of Niagen ie NR


As I delve into NR, not aware of how it started, only analysis of effects, many questions came to my mind, answered greatly here.

Why absent empirical data? And I can understand his point about clinical trials in this area. But it still seems like a big leap from that to the nutraceuticals industry (here’s more on the company’s founding). But then “As one scientist recently put it to The New Yorker, the antiaging science being done at Google-backed Calico Labs is “as self-serving as the Medici building a Renaissance chapel in Italy, but with a little extra Silicon Valley narcissism thrown in.””

What is aging?

Similar to 7 factors of deGrey SENS, this is another intuitive
list –
1.  Oxidative Damage
2.  Cell DNA Damage
3.  Mitochondrial Damage
4.  Tissue Glycation
5.  Lipofuscin Accumulation
6.  Chronic Inflammation
7.  Immune System Compromise
8.  Neurological Degeneration
9.  Declines in Hormone Levels
10.              Susceptibility to Cancers
11.              Susceptibility to Cardiovascular Disease
12.              Telomere Shortening and Damage
13.              Programmed Epigenomic Changes
14.              Stem Cell Supply Chain Breakdown    
15.              Incorrect protein folding
16.              Accumulation of Progerin
17.              Gene mutations leading to hellicase abnormalities
18.              Increasing mTOR signaling
19.              Declining hypoxic response
20.              Micronutrient triage with aging

Absent empirical data, how can one have any faith in NR?

1.       Quality of people lined up: MIT  Lenny Guarente (planetary aging expert), he’s being advised by five Nobel Prize winners and two dozen other top researchers.
2.       Width is important! Typical run-of-mill criminals can not afford by have to lie – means fuck caught! The star cast, Google calico lab.
3.       People lining up without need!
4.       There are great people who disagree with me! And Barzilai knows about the science of aging. Heis, after all, the director of the Institute for Aging Research at the AlbertEinstein College of Medicine in the Bronx. To me, perfect critic! He peddles the drug in question, metformin, to me not exclusive!

Why not wait for data? Won’t wait for 2020-2030. Ready to waste limited money.

How can CDC be shorted? No pharmaceuticals but nutraceuticals!

Why bad idea?

1.       Criminals an call their stuff (with some evidence only) just as good!
2.       Cant protect by patents! Any one can copy you.

How can you prevent copy cat criminals?

1 line up many greats
2 Not done, but I will – joint denunciation of competitors

How can non-rigorous studies be done?

1.       No one but I can, motherfuck other protocols easyu
2.       Mine will be immune. All based on aafiber!

Why is the Elysium methodology bad business?

Whatever they do can be copied!

Bad business, so what?
1         Scientists do not care of profits beyond reasonable STANDARD.
2 My method can be applied! To do my stuff fast, must use free must-extend-only-free stuff. What if 95% of my stuff was free, only thing making money was sqrt of cloud, method never sold, a user can check by squaring, I was not lying! How the sqrt was done MY BUSINESS only. For aging, a complicated protocol, largely bullshit. The copycats wont know what NOT to copy! For example a useful step may be broken, there might be slow poison – antidote steps. Mind you, be bad idea for pharmaceuticals. But OK for nutraceuticals! The expertise has no legal value!


Friday, July 28, 2017

Dead people and pets to diamonds


https://www.facebook.com/photo.php?fbid=1397652940288589&set=a.183367345050494.65944.100001316904182&type=3

http://aaqg-arunarya.blogspot.in/2017/07/dead-peopleand-pets-to-diamonds-httpswww.html

Orders for diamonds made from human cremains aren't the only type that Algordanza receives. "First we had the cremains of a German Shepard and now we have cremains of a cat," Martoia said.

Algordanza's prices start at $3,000 for a 0.3 carat diamond. Martoia said the average order is about 0.4 to 0.5 carat, though US customers usually request bigger, 0.8-carat diamonds.

But Algordanza can make them much larger: The company recently took a $48,000 order for 2-carat diamond. After 10 months of growth, the resulting gem actually wound up being 1.76-carats  — but it's still the largest memorial diamond ever made by the company.

Some customers take the rough gem, but many opt to have their memorial diamonds cut, faceted, and polished by a jeweler in Switzerland.

Inside awaits a rough, uncut, and unpolished diamond.
Description: Some customers take the rough gem, but many opt to have their memorial diamonds cut, faceted, and polished by a jeweler in Switzerland.Description: Inside awaits a rough, uncut, and unpolished diamond.
When enough time has passed, technicians remove the puck of graphite and crack it open.
Description: When enough time has passed, technicians remove the puck of graphite and crack it open.

Source: Science Channel
Depending on how big a customer wants their diamond to be, it can take six to eight weeks in an HPHT machine to coax graphite to crystallize into a gem. "The larger the diamond, the longer it takes to grow," Martoia said.

That's like the entire mass of the International Space Station bearing down on the face of a wristwatch — then heating it up to a temperature exceeding that of lava.

That machine can heat a growth cell to nearly 2,500 degrees Fahrenheit. It also squeezes the cell under 870,000 pounds-per-square-inch of pressure.
Description: That machine can heat a growth cell to nearly 2,500 degrees Fahrenheit. It also squeezes the cell under 870,000 pounds-per-square-inch of pressure.
Source: Algordanza
To emulate that environment, Algordanza inserts the cell (now packed with graphite) into a platter and slides it into a high-temperature high-pressure (HPHT) growing machine.
Description: To emulate that environment, Algordanza inserts the cell (now packed with graphite) into a platter and slides it into a high-temperature high-pressure (HPHT) growing machine.
Natural diamonds form out of carbon that gets stuck in lava tubes about a mile deep in the Earth's crust.
Description: Natural diamonds form out of carbon that gets stuck in lava tubes about a mile deep in the Earth's crust.
The final purification step converts the carbon into slippery sheets of graphite — the same type of carbon in pencils. Graphite's microscopic flat sheets of carbon are an ideal starter material for synthesizing diamonds.

The cell also contains a tiny diamond to help the carbon crystallize into a rough shape, since carbon crystallizes best when it touches an existing diamond.
Description: The cell also contains a tiny diamond to help the carbon crystallize into a rough shape, since carbon crystallizes best when it touches an existing diamond.
The diamond provides a "blueprint" for the carbon to work from, which means the new diamond that eventually forms will require less cutting and polishing.
To further purify the carbon to 99.9% or more, technicians pack it into a growing cell that contains iron and cobalt — additives that help remove contaminants.


When Algordanza processes ashes, Martoia says, "it's nearly impossible to separate out the boron from the carbon". This is because the two elements share similar weights and properties.

"The diamonds can range from clear to very deep blue," Martoia said. "The more boron, the deeper the blue."
Description: "The diamonds can range from clear to very deep blue," Martoia said. "The more boron, the deeper the blue."
She added that it's impossible to predict the exact color a memorial diamond will take on.
"But an interesting thing to note is that our technicians are seeing a correlation in people who have had chemotherapy. Their diamonds tend to come out much lighter," Martoia said. This may be because chemotherapy leaches away the body's boron and other important micronutrients.
Boron is the impurity that colors the rare blue diamonds found in nature — and is why many "memorial diamonds" come out blue, too.
Description: Boron is the impurity that colors the rare blue diamonds found in nature — and is why many "memorial diamonds" come out blue, too.
The other 1% contains impurities like boron — an element and micro-nutrient that helps humans (and other animals) grow bone, heal wounds, and regulate the immune system.

This bumps the carbon purity of the processed ashes to about 99% or greater.


Once there's enough carbon, the element is extracted and purified of contaminants like salts. "We use an acidic chemical to get rid of impurities," Martoia said.


When the company receives ashes from a customer, a technician puts a sample into a special oven to see if there's enough carbon to grow a diamond. If there's not enough, the amount of carbon in a lock of hair can make up the difference.


Martoia said Algordanza requires a minimum of one pound of cremains. "That's kind of the magic number, where our engineers can guarantee there will be enough carbon to make a memorial diamond," she said.

Making a diamond from a dead person begins with cremation. The process typically leaves behind about 5 to 10 pounds of ashes, much of which is carbon.
Description: Making a diamond from a dead person begins with cremation. The process typically leaves behind about 5 to 10 pounds of ashes, much of which is carbon.
Styles of cremation differ from culture to culture. Some use hotter temperatures for longer, which allows more carbon to escape into the air as carbon dioxide (which may mean more ashes are needed to form a diamond
Algordanza

Arya Add: A 0.2 Carat is sufficient. I seriously consider a 1000 year company that allows any one to add their diamond to that of ancestors. Over 1000 years, it will become very valuable – by jewel and by history!

Thursday, July 27, 2017

Tech fi, open plausible unlikely, but interesting


https://scontent.fdel1-1.fna.fbcdn.net/v/t1.0-9/20292784_1396917127028837_6807832428839083145_n.jpg?oh=2b7e83488fb9a7ca8619f450646201fe&oe=5A0B92EB

Astronomers Discovered A Second ‘Alien Megastructure’ Star That’s Even Stranger Than Kic 8462852

130 years of data!



see also
https://www.space.com/33813-alien-megastructure-mystery-tabbys-star.html

Dyson sphere is what I wou7ld build, given that kurzweil et al "fantastic voyage" excites me.