Friday, February 4, 2022

Spanish aging Bible


Translation results

La biblia española del envejecimiento

La Biblia en el título es para abordar la sección dominante de los humanos que conocen su impacto y continuidad cambiando a medida que cambia el lenguaje, exactamente como la ciencia en la que creo, no en el opio para los simples judíos. ¡La larga edad requiere una lectura dedicada y una compra y alimentación activas de suplementos que pueden lastimar o están involucrados en conspiraciones de supresión de la demanda! 

Bookstart

https://aaqg-arunarya.blogspot.com/2022/01/spanish-book.html

Book middle

https://aaqg-arunarya.blogspot.com/2022/02/spanish-what-next.html

Book MEAT

https://aaqg-arunarya.blogspot.com/2022/02/spanish-interventions.html


Resto de páginas 

Una subsección de media página a tres páginas sobre estos: 

B3

Niacina

NR

NMN (en inglés) 

NAD+ 

Nadh 

AKG 

TMG 

Fisetina 

Espermidina 

Quertecina 

Apigenina 

Flavonoide

 Resveratrol P

terostilbeno 

Sirtuina 

AMPk 

mTOR 

HGH 

IGF 

Cáncer

 FOXO 

Zona azul

The Facebook aging bible

aging bible

Bible in the title is to address the dominant section of humans who know its impact and continuity changing as language changes - exactly as science I believe in, not in opium to simple jews. Long age requires dedicated perusal and active purchase and eating of supplements that may hurt or are involved in demand suppression conspiracies!

First draft

 thankyou

https://aaqg-arunarya.blogspot.com/2022/01/english-letter.html

Bookstart

https://aaqg-arunarya.blogspot.com/2022/02/english-book.html

Book middle

https://aaqg-arunarya.blogspot.com/2022/01/top-age-reductions.html

Book MEAT

https://aaqg-arunarya.blogspot.com/2022/02/intervention-meat-at-last.html

interventions

https://aaqg-arunarya.blogspot.com/2022/02/contributions-i-am-computer-scientist.html

Rest of pages

One subsection of half-page to three pages on these:

B3

Niacin

NR

NMN

NAD+

NaDH

AKG

TMG

Fisetin

Spermidine

Quertecin

apigenin

Flavonoid

Resveratrol

Pterostilbene

Sirtuin

AMPk

mTOR

HGH

IGF

Cancer

FOXO

Blue zone


The Aging Bible 0

 The Aging Bible

Bible in the title is to address the dominant section of humans who know its impact and continuity changing as language changes - exactly as science I believe in, not in opium to simple jews. Long age requires dedicated perusal and active purchase and eating of supplements that may hurt or are involved in demand suppression conspiracies!

First draft

https://aaqg-arunarya.blogspot.com/2022/02/english-thank-you-0.html

Bookstart

https://aaqg-arunarya.blogspot.com/2022/02/english-book.html

Book middle

https://aaqg-arunarya.blogspot.com/2022/02/english-goal.html

Book MEAT

https://aaqg-arunarya.blogspot.com/2022/02/intervention-meat-at-last.html


Rest of pages

One subsection of half-page to three pages on these:

B3

Niacin

NR

NMN

NAD+

NaDH

AKG

TMG

Fisetin

Spermidine

Quertecin

apigenin

Flavonoid

Resveratrol

Pterostilbene

Sirtuin

AMPk

mTOR

HGH

IGF

Cancer

FOXO

Blue zone


Thursday, February 3, 2022

Overview of my 3-month experience

 My final report is due in November this year. I am excited enough to wait for that day. Based on my experience so far, things are way better in portions and disappointing in others, no worsening. But disappointing of my expectations despite good immediate results elsewhere, perhaps additional things must be done in conjunction, there has been no worsening of decline.

De-aging was never the central reason, even though my entire effort is so structured, lifespan is not the issue but healthspan is, ie running it to measure the improvement in decrepitude. I am very concerned about my future from comorbidities of diabetes, heart disease, osteoarthritis, and creeping senility beyond bipolar-ness and suicidal thoughts. A Reformed loving family has solved mental problems to a less-concerned state. My de-aging regime has had similar preliminary effects on diabetes and heart problems. These are personal views buttressed with some data,

I learned in the USA that scientific attitude extends to entire life. To health it means spending money and effort to measure the body response, even normal humans can rise to what is required by empirical tests. The stupidest things to do to self suffer from the consequences of doable things above criminal negligence. Not knowing can be deadly. Regardless of your views on my philosophy possible like error minute, believe that self-applied empiricism drives human motivation. And also that knowledge finds strange applications. The forced course in calligraphy by apple's founder STEVE jobs was instrumental in Lisa's interface. My adventures in encryption are basic to my secret in defeating the crypto chain. My care of self is basic to my self-clinical tests and extraordinarily dangerous as my MIT-published Bits topper brother-in-law discovered. One can only proceed to really understand anything by NASA design approach. If it can go wrong, it will. Marry it to my teaching summary -Understand reasons even of the obvious. Research is very hard and time consuming except in new fields. Even pioneers are not divine.

 

aaa-Rejuvenation

 I believe, without question, the efficacy of recommendations made by my expert panel. Currently, they include only doctors that have performed one Nobel prize deserving research and have still continued work to another Nobel deserving research.

This leads to the next question - what is my role? It has been chosen by aaa-panel expert Dr. Aubrey de Grey as the second point in his talk - how to compose reliably, the recommendations of individual doctors. It can only be done, say I, by empirical clinical tests, perhaps by FDA or a sister organization, but I refuse to wait. It will likely take over from me, ethical organizations, consumer-created organizations immune to lawyers, but capable of and experimenting with lawyer-induced total mother-fuck of animals who would illegally abuse our trust to whatever ends without written permission.

Every doctor has the right to think they performed Nobel quality work but none to claim aaa-panel without our written permission. No permission has been sought or is necessary from initial members. They are

1.    Dr de Grey, for introducing/developing an engineering approach to the aging problem and senolytics

2.    Dr. Sinclair, for NMN and 2019 theory of Aging

3.    Dr. Yamanaka for inventing Yamanaka factors and iPSC.

4.    Dr.Horvath for DNAm/GrimAge and Eutherian  applicability of methylation

5.    Drs. Conboys for initial hetronic parabiosis and not young blood  but plain protein works

6.    Dr. Fahi for TRIIM and TRIIM-X

There are many single Nobel like yet including Dr. Barzilai (TAME), Dr. Katcher(E5), Dr. Malone (mRNA), ...

The aaa-panel greats can disagree and in this case, the consumer is on their own. To escape lawyers, every recommendation by me must belong to aaa-trusted components, available as supplements, and require no MD service. Only registered consumers, tracked by registered Doctors of the country transparently knowable of all. including non-recommended edibles, must be known. Only the registered doctor can upload the data to me. I shall collect data, compile them with other medicine too, and publish the data to benefit all self-testers. No, but annual charges, devoted to the communication of results too, will be levied beyond the first applicable to Dec 31.


English Book

  Overview 2022

 

My colleagues and their loved ones continue to die, no one has reported, despite their attempts to apply, cutting-edge technology. It must mean one or more of

 

1.     Unfamiliarity with modern aging science

2.     Knowledge but conscious decision to escape likely useless expense

3.     Lack of belief from some kind of fatalism, luck, religion, etc.

 

About #3, everyone has the right to be stupid, except our civilization will advance to a state where such morons will be charged with murder of responsibility. The same applies to greedy of #2. People in #1 will be charged with negligent homicide, exactly like the accident-involved driver.

 

The only tolerated defense is I tried in this way (of top scientist) after reading and still failed.

 

Who are these top scientists and why?

 

Every person who argues anything not empirical is a meta-moron. All in the top list did Nobel quality work (acknowledged in the aging community by the overwhelming majority) and followed by delivering another such research.

 

There are only a few, found by continuous work of 20 years

 

The whole top field of Aging

1. Dr de Grey, for introducing/developing an engineering approach to the aging problem and senolytics

2. Dr. Sinclair, for NMN and 2019 theory of Aging

3. Dr. Yamanaka for inventing Yamanaka factors and iPSC.

4. Dr.Horvath for DNAm/GrimAge and Eutherian applicability of methylation

5. Drs. Conboys for initial heterochronic parabiosis and not young blood but plain albumin works

6. Dr. Greg Fahy for TRIIM and TRIIM-X

 --------------------

Unlike. any normal human, A scientist, to me, is one who keeps his religion strictly out of the propounded theory. It can not matter what their belief system is, I only believe in empirical theory everywhere, It matters not what he divines for his beliefs from empirical theories. God is NOR dead but irrelevant to my science. This means empirical facts remain independent of their theories. You have to prove everything from empirically constructed theories. Next is personal despite excellent folks who believe otherwise, they remain meta-morons and vulnerable to sophisticated thugs exploiting their stupidity.

The aging theory has been the essential goal for 4000 years since the dawn of written language in Mesopotamia through empirical novels of Gilgamesh. Since that time many fraus have arisen. How can you decide I am not one too? Because I only state this story on empirical proofs by Dr. Sinclair at Harvard. Any mistakes are mine and will be corrected once pointed out.

How can one provide proof empirically for any theory of aging? First, you have to accept evolution. Then you demonstrate the correctness of your theory on mice, doable much faster given their small lifespan. Also, it is ethical to sacrifice mice.

The mice have their optic nerve destroyed by crushing. Next, mice in this experiment prove mice have gone blind. How in mice? Mice stare at lines. If not blind, then their throat moves their head to the side the lines move. All crushed optic nerve mice prove they have become blind, Now the NAD+ boost is done. All the mice so treated get back eye-sight after treatment. Their eyes act like genuine eyes for the rest of their life. Note that I skip over treatment which is done by triggering genes.

So aging is understood in mice. Same works in other animals. By evolution, also applies to humans. The experiment has a human analog, for whatever reason, people end up with diseased optic nerve and become blind. They can be cured with an analog NAD+ boost.

A full life of the human-animal?

A human or any sexual evolution animal starts from a single cell called a zygote that fuses the mother and father DNA halves. The DNA of the zygote divides repeatedly over the birth intervals. The DNA has an epigenomic layer that modifies the cell by context. Eventually, the birth-human is produced. It keeps growing till adulthood. This happens with a continued division of stem cells. The body is repeatedly attacked by useful microbes and pathogens. There is a full-fledged immune system for inbuilt and adaptive immunity.

Humans and similar animals have 3 classes of enzymes that control the stem cells. The stems do not wither away. They stop their growth activity as a consequence of chemical signals. They are needed badly in wound repair till death!

The classes are Sirtuins, AMPk, and mTOR  Keeping them occupied is how aging will be intervened in Singularity 1.0. There are 7 Sirtuins, which only Sirt1 will be focused on. AMPk and NAD+ improvements are sought. mTOR signals abundance and increases with proteins signaling body no longer be in an alert state, shutting down repair machinery deployed for fears of starvation. This is counteracted by fasting, exercise, low sugars, low proteins, etc. These are excellent ways to fool the body which responds by hunkering down for adversity!

Roughly, NAD+ boosters (sirt1), metformin (AMPk), and low dosage rapamycin (mTOR) affect the growth genes. One has no dangers of body growth because the stem cells are halted by independent chemicals.

Very brief cell biology required to understand Aging and mRNA vaccines?

A cell has many compartments. Interest to us are

1. Nucleolus sack containing the DNA

2. zero plus mitochondria sub-cells

3. Ribosomes

How does a cell work? Two top important processes are making a protein and making energy.

To make a protein, it is somehow included as query protein, which enters the nucleolus and matches the short-chain in DNA which produces mRNA with one new sugar, enough to mark the molecule as mRNA that now exits the nucleolus. Once in the cell, it unites with a ribosome and makes the needed protein. The mRNA is still there and can not reenter the nucleolus. It dies as programmed to die quickly. Sometimes it exits the cell but is then eaten by an immune cell.

Or the signal might make energy, then ends up in a mitochondria subcell. They have their own small DNA. In any case, the signal causes production from ATP by Krebs using NAD+.

Why does NAD+ decline and what if it does?

NAD+ catalyzes many Krebs subcycles. It is basic to convert to energy, autophagy, and apoptosis. NAD+ is slowly, and with difficulty made from vitamin B3 in each cell, and is used in many sub-cycles in the Krebs cycle in so many animals and human cells. Its loss hurts by lack of energy, weakened immunity, more cancers, and many chronic diseases.

It declines because it bothers dead senescent cells which accumulate because of autophagy and apoptosis decline. To adulthood and near beyond, bad cells are garbage collected and replaced by new daughter cells from division. But that does not happen with age. The dead cells accumulate. They take to producing SASP. Some make neighbor cells senescent too. Others simply neutralize NAD+ which bothers dead cells. Each dead cell not removed is a big problem.

Hallmarks of Aging?

Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contribution to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging with minimal side effects.

new friend links

 Spanish

thankyou

https://aaqg-arunarya.blogspot.com/2022/01/spanish-letter-2.html

Bookstart

https://aaqg-arunarya.blogspot.com/2022/01/spanish-book.html

Book middle

https://aaqg-arunarya.blogspot.com/2022/02/spanish-what-next.html

Book MEAT

https://aaqg-arunarya.blogspot.com/2022/02/spanish-interventions.html


English

thankyou

https://aaqg-arunarya.blogspot.com/2022/01/english-letter.html

Bookstart

https://aaqg-arunarya.blogspot.com/2022/02/english-book.html

Book middle

https://aaqg-arunarya.blogspot.com/2022/01/top-age-reductions.html

Book MEAT

https://aaqg-arunarya.blogspot.com/2022/02/intervention-meat-at-last.html