Evidence-based Supplementation for Aging

latest link

What is the best supplement for anti-aging? What supplements are scientifically proven? What vitamins help with aging? What is the recommendation for daily multivitamin supplementation in older adults? If you are impressed by non-EBS here,

Get lost, following is definite waste of time.

Aging is a universal disease from accretion of DNA damage in cells. That is my dogma adopted after several dozens of years of study, experience and nmn supplementation of three months. Aging is independent of quality of thoughts and belief – properly administered NMN and B3 vitamin forms work equally well for saints and criminals, believers, disbelievers and agnostics. FDA does not classify it so at this time and that opens up many avenues.

MY EBS complex, properly used will do something desired for 50,000 years, ever since human advanced to writing – a way to defeat death. I can aver after trial on self – it is not simple NMN, details are important. Like physicians, details are crucial. The components are known – NMN, TMG, CoQ10, omega-3 etc. Proper benefit is through proper use! Example is NAD by blood infusion, NMN sublingually. Goal is to overcome common afflictions of old age besides getting the energy through NMN, which itself is complicated by need for TMG or Betaine! That means Dec 2018 literature! Searching in MD literature is a waste of time – few believe in it and even fewer gel the experiences of bio-hacker as me!

Mice testing makes a golden hypothesis much better than anyphilosophy or education. However, a hypothesis may fail, or apply differently. Mice are fed NMN about 500 mg per kilo and through water drink. Immediately NR-NMN controversy starts as does sublingual versus capsules. Immense doses of B3-like are used, they require methylation for emission as piss. If you do nothing, they damage homocystein that creates inflammation like heart disease!  Why not use NAD+ or NaDH directly (cross into brin but bas cell entry! Tricky details.

Betaine or TMG or B-15 vitamin has three methyl groups and performs methylation. Even better is choline but that is bad for a diabetic as me! Also dmg exists but has low strength to TMG. TMG is used, along with other chemicals to lower homocystein which is a measure of inflammation of heart patients. Unlike cholesterol, with no evidence support in heart events, inflammation is evidence based Factor! The key lowering agent TMG is also available as supplement!

This brings me to analysis of self as Evidence-Based Supplementation expert or EBS expert. First my thinking is scholarly – no facts except evidence or derivation. Result is hypothesis for which evidence is mandatory. Because I deal with supplements only, my work is complementary to doctors. In all matters when timing is an issue. Regular Allopathy is supported, not Ayurveda, Unnani or Chinese. My claim is serious doubts in sanctity of medical education at large with significant differences on long-term management because of serious doubts on facts by continuation of claims of elders and supposedly truth saying ancients! These are always hypothesis generators for evidence based truth! Regular doctor has no business giving opinions on diabetes, heart events and cancers. FDA testing of medicine is flawed because they do not explain how much better. Especially important to cancer patients where 10 % BETTER is convincing to a patient but may not mean much for management of estate, price of drugs and possible minuscule improvement in survival chances (0.1 % to 0.11 percent)!

Harm is central! No point in any routine that requires medicine like absoluteness! Most supplements have no schedule or sharp dosage. Except that sublingual has a required gap. NMN needs to be mixed, with at least TMG, if not more. Such a mix of 4 as been patented by EGA as EGAceutable! What about another, based on NMN and TMG but not the others! No troll is likely to bother you! That is safety one. What about with TMG but different from you? Aging is a huge market – every human gets old. It will be easy to get competition into any XYZ with regard to life extended.

How can you tell? People have public age. Also a biological age. Chronological age is the number of years a person has been alive, while biological age refers to how old a person seems. Biological age, also referred to as physiological age, takes many lifestyle factors into consideration, including diet, exercise and sleeping habits, to name a few. Value in bioage cannot be manipulated! It is directly related to expected life!

So application of TMG, and dosage of form of B3 constitutes virgin territory which I will occupy and my usefulness can be measured. I also escape from medical establishment. Open challenge – if you be better then show it in open test! Bioage is standardized.

TMG is Dec 2018! I start on it middle of next Jan. I will get bugs out by self test! TMG can’t hurt as is very docile molecule, in any case good for my heart! More complexity I encounter, better is it for EBS. Already B3, niacin, nicotinamide, NR, NMN, NAD+ and NaDH choices with administration by food, sublingual or intravenously, Doages and mixes! You must have deep biology interest and reading to crack EBS. And also real belief in work to try it on self!

GENE EDITING

latest link

My interest goes back to 1976 when I studied and liked L-systems (Lindenmeyer). Botanists were trying out L-systems to understand the construction of tangle of flowers. This requires propagation rules in context sensitive grammars. Context-free were the rage then, but insufficient to control, specific changes in several sites. This time dependent behavior required rewrite rules with context! Specific required context could be propagated to desired places only.

I became a compiler writer with expertise in yacc which dealt only with LR(1) subsystems of context-free languages only. I developed great attachment to attributes, rewrote yacc to allow attributes and come up with two level context-free (LR-1 really) and two-level LR-1 really is most powerful possible(two-level CFG = type 0)! Attributes are really for context-sensitive ness! When done, attributed LL-1 grammars will rule the world, even better than Go. Go is great for it encapsulates, Ken Thompson ideas on parallelism and has parallel garbage collection!  My language, improving Go is eventual, though more like Haskell.

But here we only apply to crispr for genetic editing. One can capture scientist work to create an appropraite model of production of an organism from the root cell. Despite ethical storm from germline edits, I limit to crops! There is a worry that in using CRISPR-Cas9 to repair one disease-causing mutation in human embryos, other potentially harmful mutations may be unintentionally introduced. To understand this consider context sensitive rewrite.

A  T  G C

G T C A existing DNA

T C A G

In this suppose out goal is replace middle sequence with AGTC  TAGC. OUR conext-sensitive rewrite is

A  T  G C         A  T  G C

G T C A  =>     A G T C

T C A G         T A G C

                    T C A G

Clever bio-chemistry later (context and replacement becomes an RNA that mixes with DNA, mix replaces this context sequence atgc tcag in all places. ATGC TCAG are matched and cut happens in middle there.

DNA forms a double helix. Ca9 may cut both, different RNA only 1, then two different RNA are needed. Both can have different contexts. One can improve cutting so. The chance of wrong cut is smaller! Together with more context, accuracy may be increased.

Crispr-cas9 is best now, but competes with transcription activator-like effector nucleases (TALENs) and (ZFNs).

Recently a Chinese scientist He applied to human germ-line, produced babies, and was roundly criticized! Easy bad science giving bad-name to non-germline research! Why? Only way to trace errors is repeated genetic testing of humans so produced! What if error found, what do you do! What if error in germline DNA? Horrible questions, no answers. Non-germline errors in one in individual only!

NMN epistemology and appplications

SELF LINK

In this context means "who to believe". I have followed Dr. Sinclair into FDA yet-untested NMN (3 tests, 2 in USA, one in japan due 2020 or more) uniquely qualified to achieve this and persuade because he has successfully tried on mice, has fed himself and parents for 12 years, looks 20 year younger, can convince me he does not need money directly or as a front (is billionaire from invention of reservertrol, ALL age-sellers = used car salesmen!), chosen by NASA for health of Mars astronauts, tenured faculty in Harvard medicine. Only lack of manipulation angle means him and not elesium/chromadex NR. All sellers are safely considered greedy with onus of sincerity proof on them!

Given any human of even moderate intelligence, amortality (different from immortality, healthy long life span) is a natural wish, every subhuman knows it, knows how to get it, or knows teacher who can. Any scientific thinker (not a subhuman believer) must be able to derive and only derive every aspect of whatsoever considered science (All required). This constrains epistemology - every derivation is a hypothesis, derived by hunans who could be wrong. The hypothesis must rationally derive the results. Thus ONLY expect able scientists are rational skeptics. Given the paucity of developments from the first principles, a scientist must provisionally accept certain facts, has an epistemological theory of who to believe when, and forms a rational stoic. Provisional acceptance of "blood sugars by Reddy organisation" is done by me to avoid the costs of the Max hospital, but not many others. This is rational stoic decision even absent my test. It may be different for others, in some cases just as good as mine, often less rational, but always other person choice. I retain the right to argue - an agree to disagree never implies error, only pointlessness of further argumentation!

It is particularly true for NMN. Rather than NMN, let us talk of X and my belief in it. I assume that some one else praises a Y. Why is my X superior to Y!?

Unless Y is accepted in a scientific way as rational skeptic, Y is bad! At once! All religious or most atheist products fail as no scientist have bothered yet. There are still conflicts betteen elisium products, possible claims like mitoq etc. So no blanket rejection helps there! It is no different than rational sketicism applied to products, Why is one better?
Anecdotal proof against aging exisr! Not enough by itself! Cap[italist monsters from america can buy endorsements!

The endorsement must be from applicable master scientists. Reduces field to NMN, NR, elisium, mitoq etc. All these are endorsed by master-scientists.

Things like mitoq etc do not claim general fight against aging, only effectiveness against specific patholgy.

So fight remains between NR combinations, NMN, NAD+ and NADH. All are steps in conversion of niacin (natural vitamin B3 to NAD+  which all cells can use in energy Krebs cycle and thus alleviate aging symptoms. NAD+ amount continuously declines with age.

You benefit from all. However bio availability in various cells varies a lot. NAD+ directly does not enter cells. Neither does NMN! NMN has another problem - it does not easily cross blood-brain interface by itself. Niacin causes unpleasant flushing! The effects vary with form. NR and NMN cost a lot, as does NAD+ and NADH but B3 - flushing niacin or  non-flushing nicotinamide form) is very cheap but glacial slow.

One way to consider situation if bio-availability depends of distance from NAD+ (which is needed). NAD+ is 0, NADH is 1/2 away. nmn is 1 away. NR is 2 away.Niacin is 3 away. No one but NR enters a cell - NMN< NAD+ and NADH must become NR to enter and must revert back to what they were. Depends on cell i.e. afflction to decide which one!

Neat solution for normal humans is some NMN and some NAD+. Latter to help Alzheimer's, essential tremors and Parkinson; all affliction of brain. How to take them? Sublingual, NAD+ at morn and post dimmer presleep, while 5 does of NMN per day. do it 4-5 days per week.

All tests are on mice now. 3 big human studies have started, safe MD data by 2020 or 2021. Freezes looks at start - bad idea to wait unless proof - there is no -ve effect (NMN,NAD+) very inactive. Just prevent liver step by sublingual!

Home automation

Latest Link

A fun deep idea for cheap automation USING WIRELESS control.  Any switchable thing.A fun deep idea for cheap automation USING WIRELESS control. Any switchable thing.

optional-Wish-death - arya-religion

latest link

An optional-wish death is NOT a death wish but the opposite - die only when wish dead i.e by suicide in billion or trillion years!

I have never explained the genesis of anti-aging and superiority of science in anti-aging. Reason of wide-spread apathy is simple, bio-types find it too elementary, other science types find it impossible jargon-laden and revert back to naivety. There is one simple key – there is only one known way of increasing age over all kinds of organisms and humans – calorie-restriction, too hard and dangerous by itself! All effortssimulate benefits of restriction at molecular level.

Every emotional thing in humans happen chemically. All life is cellular. It follows that given all organism age, aging is chemically in cell reactions. What is common to all life? Consumption of oxygen in ATP-ADP sub-cycle to CO2 in Krebs cycle. NAD+ is a required co enzyme in it. Its concentration decreases proportionally with aging. Kids have lot of it, also energy. Drops to about half at 60 and decreases exponentially with age. The model of aging I have it that aging progressively causes error in DNA, expressed in lack of NAD+. Note that DNA is in nucleus while Krebs cycle happens in a mitochondria. Bio-availability concerns define a doctor over a bio-chemist.

If Aging happened so, lifespan will be in months. Fortunately, cells are replaced regularly, old cells garbage-collected through apoptosis. So to fix aging, two things are needed, fix NAD+ or cell genesis. First I have talked in detail. Second is by transfection. That is the only fix for trees (also cellular) which live for thousands of years.

So my recipe of wish-death – NAD+ fix for 150 year, thousands of years by transfection and consciousness-upload in 1000 years. ALL religions are stupid and best solution is wait for believers to die naturally. That is how idea-evolution happens anyway!

Nicotinamide adenine dinucleotide (NAD⁺) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate–ribose) polymerases. Cellular NAD⁺ concentrations change during aging, and modulation of NAD⁺ usage or production can prolong both health span and life span. Here we review factors that regulate NAD⁺ and discuss how supplementation with NAD⁺ precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases.

One can imagine many long term problems not addressed yet or even imagined. Cure will be found for all within my life-time. Belief in this is religion, only one I have, other than cultural habits which may lead to early unwished death!

Creation of old-age amelioration facility

No one has escaped the ravages of old age. Death is universal, but long suffering before it comes is not! Stupid way (except perhaps ok with great suffering no-help cancer, etc) is suicide. I sought a way to stretch my youth to death with proven lifespan at least normal but expected longer! In short, extension of youth at this point requires reversion of age related effects no longer held back by supplements. My definition of extended youth includes extension of sex drive and fulfillment to say age 90 or 100, One must have clear avoidance of arthritis, Alzheimer’s, osteoporosis, and Parkinson – 3 destroyers in old age after victory over heart disease, cancer, stroke etc. Not excluded are ethical exchange of blood with younger givers.

Perhaps it is not!

After 20 years of research, it is and incomplete but definite first cut is here! Other people think like me, have even early advantage over me, but will not be able to survive my competition using medical tourism to India! Most of my adversaries fail to realize the new India, its competency and strict discipline I am capable of.

There is one very special distinction of my investors that make it very different from all other investments – the investor has no escape from old-age! The best investors are patients. Roughly double the cost will be my charges. If you like my setup, you become small investor. If not, you get hals your money back, no questions! I expect 10-20% of patients to become investors!

I use my rentals in Greater Noida to get started. Initial investor enthusiasm determines the speed of ECP and HOT components. Some initial investors only invest their time. That is how medical and management will be structured.

I will start out by on-drip NMN, NAD+ and NADH. Price will be $13000 minus india benefit. Covered will be free economy premium! The drips will be operated by professional competent medical staff, present the full time! I pay for it and ambience for 10 days of full day drip. Perhaps you can determine a fit and become an investor of time! No money investment is needed at start – I provide the real-estate, maintenance, drips and staff salaries! The consumables (NMN etc) are included. Even if I fail, I will consider it a very expensive way against age as I and my family will be users like all.

Let us assume I fail. Kind of brusque person I am, not the best teacher but good professor, I am ready to fail! I keep my real estate, I waste on drip instruments and 3 month salary. Around 10 lakh. Bearable!

A 28 day drip-adventure in Texas will cost me $30000 i.e. @20 lakh rupee, stay separate – I believe in self research any way! Fuck the non-scholarly critics unless an MD medical doctor!