Intervention contributions
I am a computer scientist who speaks about aging, which is a medicine subject. What do I bring to the table as value-added and why I am convinced that my improvements are unlikely to be stolen? How do I intend to monetize the benefits to me?
Aging reversal means moving repeatedly -ve bio-age. Only Yamanaka short-term and stem/telomere method with slower cycles. I believe so strongly that I tried my own mix on myself. I haven’t died or had any known -ve effect, I am 6 months to going to the USA (now 12 months of 1-.5 year self-clinical trial) to get DNAm bio age for self. It will likely be much younger based on feelings and 8/8 unknown stranger age assessment.
https://blogger.googleusercontent.com/img/a/AVvXsEhczekFhX-goPZ9Wh1Q6jwPGbsqJKctMSq5rAHQFBx1vacgx2dlhTi25hwxrSddug09kCtyQ9vtivTzO1oKRsnBKMDLvFtvWUxViWm01ZoluT7Tsp64n7X06J5q_ajOxuQOu3Y76Ohr1tXj-KDswF8tNvabF4w4iXGRGLuogOXX1fPD_Gjucf_0GuQt=s800
What is my secret is based on this:
All my derivations are based on above, a standard dominating subset of draws of Hallmarks of Aging in 2016. Above dominates hallmarks of aging:
Intervention diagram
https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3836174_emss-55354-f0005.jpg
www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174
Flatline means inhibits, arrows means to boost. The bottom is aging. So to reduce aging, you want to boost AMPK, sirtuins, and igf-1, and reduce mTOR. My theory, alone, agrees with Dr. Fahi, but suggests further improvement by low-dosage rapamycin! California billionaires use igf-1. MY COMMENT MEANS A LOT. I consider GMO igf-1 since GMO is solely good for medicine at a low cost.
What did I just say - trivial for a computer scientist, ununderstandable to a doctor! In graphical terms, there are 4 nodes dominating paths from top to bottom, which is aging, this diagram by me dominates that in hallmarks of aging that has almost 16000 all medicine papers references, in aging, and is considered to be central to aging in 6 years to 2022, and summarizes my philosophy. The field got going in MIT with two remarkable Ph. D. (not MD) students at MIT. They were Dr. Sinclair and Dr. Kennedy. Dr. Sinclair moved to Harvard medicine, set up his own lab, discovered Resveratrol, then propagated NAD+ boost through NMN, not NR. He became my Hero because he eats all his recommendations and is a walking example of improved health. Unlike all medicines better tested by FDA, aging medicine MUST be tested by the recommender because all grow old and the world has more criminals and stupids than sane effective. Even if FDA approves, there is no trust in me, unless the recommender shows benefits and transparently applies them to self and own family. Dr. Sinclair's brother and father are on too, and father shows spectacular improvement (weight lift at 80, enormous walking, and learning for a 2nd career).
I do it too, consider risks tolerable, will not be offended if the limited gain in healthspan, as long as my chronic diseases of diabetes, heart, osteoarthritis, and instability are addressed for a cure, undoable by top allopathy. These are thus reasons for starting on aging drugs even in youth! Further, I am worried about dementia and the loss of brain function. Great aging doctors will apply my dosages. I seek to be like Sherlock Holmes to their superb medicine and lack of aging knowledge.
Early results on me were successful, after which my mother and sister are on it too. My diabetes/sugar levels were better by 15 points and I have not needed isosorbide for 4 months, was averaging 2 pills a month. All my biggest comprehensive blood test reports were in limits and vitamin D and sodium were near the middle of the range. Do comprehensive blood tests again in 2 months. No improvement in looks yet but will measure NAD+ levels and DNAm age in October. My sister and mother are on my recommendations now.
MD recruitment for required supervision list has started who acknowledge me expert aging consultant with starting dosage schedule. I am myself, under the care of Dr. Neeti, who takes no responsibility for my chemical list but knows about them and dismisses them as vitamin-likes. The strong reason is the safety filter applied by me on chemicals with no known interaction within them and with other medicines taken for concurrent illnesses, though further safety requires a temporary halt on aging drugs.
No improvements were seen in osteoarthritis and instability. Osteopos continues, still await CaAKG and hyaluronic acid, but have taken direct NAD+ through the nose for brain entry reasons. Even marginal improvements through October means a fix for chronic diseases is happening and even no age improvements are ok. I do feel more energetic, but that could be psychological.
Growth enzymes
If one ignores the left igf-1 path, all others are under calorie reduction. These, in turn, point to Sirutins (class of 7), AMPk, and mTOR. All decline with age and last also gets a boost from left, tops GH (or Growth Hormone) as well. mTOR boosts in growing proteins, happen with many steaks for example, or foods of fit-body types. Great feeling but bad of Aging! Why? Plenty of proteins means body systems shut-down of scarcity pathways. Fatties or musculars normally do not cross 100. No lack means body paths best for scarcity shut off, the body is fooled by muscle exercise, breathing exercise, reduced diet, activity in sports, etc. Low mTOR feels low strength. But fit for Aging
In biology, errors due to DNA, bad diet, or pathogen attacks cause lacks or harmful excess. Medicines and supplements fool the body. Calorie restriction is hard and stupid since the body can be fooled by chemicals, restriction causes malnutrition. Exercise is good and bad. A chemically fooled body can live in a much longer health span. But which chemicals, when and how much, etc. Who decides? A supervisor doctor. Not any but accomplished in aging. Like me+doctor. Fool the body by intermittent fasting without reduced nutrition.
Here is my original point: no matter how motivated, a person in 65-80 age does not do vigorous exercise because of frailty generally unadmitted. It is stupid to insult the intelligence of an old to request to exercise or explain benefits. The right way is to restore some strength, to the point of an exercise. My mother is late 80’s, gets up at 5:00am, and goes for a 0.7km walk twice every day.
So many ways I help - list the chemicals based on a certain schedule, determine their safety, determine dosages and join ethical sellers and customers. Any concurrent diseases and lessons learned for intelligent patient experiences come from listed doctors.
Why I can ignore others?
Stealing from me demands fakers schedule, determine chemical safety, determine dosages, and join ethical sellers and patient customers. This note explains use but is a small part of my innovation and is sufficient for trust, known or not!
Why will doctors not be able to compete?
Any single aging solving method is very hard. There are several such methods. No developer doctor will ever recommend a competing method properly. Whether recommend or decry, the statements of a proponent must be taken with lots of salt. Composing competing methods is hard. The only person to escape this is Dr. Sinclair by methods through self-usage but that includes some disease-specific chemicals Inapplicable, even harmful to just aging solvers! Also, there is no sane way to decide others for completeness. Only I can compute completeness by dominators of hallmarks of aging and expanding them! For example senolytics like Fisetin etc, and CaAKG!
What are Dr. Arya's recommendations and why?
By dominating the graph, one identifies Sirutin1 by NAD+ boost by NMN. NO for blood vessels means Oleic acid from olive oil. AMPk boosted by Metformin or DHEA, mTOR fixed by low dose rapamycin. igf-1 fixed by GH/DHEA using TRIIM-X. Stressed organic plants products are good for boosts.
Why does NAD+ fall? Concentrations are reduced by SASP from senescent cells, hence removing senescent cells, but some for wound repair, need Senolytics after thymus decline, equals immune system declines, with age. Spermidine, Fisetin, quercetin, apigenin, peptides in general good for classes of senescent cells. Some populations of senescent cells are good for wound healing. Best decline them to needed, approximate obviously.
It was discovered through transcript analysis that senescent cells have increased expression of pro-survival genes consistent with their resistance to apoptosis. Drugs targeting these pro-survival factors selectively killed senescent cells. Two such drugs were Dasatinib and Quercetin, which were both able to remove senescent cells but were better in different tissue types. However, it was discovered that a combination of the two drugs formed a synergy that was significantly more effective at removing some senescent cell types.
In other studies, removing only thirty percent of senescent cells was sufficient to slow down age-related decline. These results suggest the feasibility of selectively ablating senescent cells and the efficacy of senolytics in alleviating the diseases of aging and promoting healthy longevity.
CaAKG fixes methyls that measure age by the remaining identity of cells. It seems to also fix other amino acids. DNA demethylation not only improves age measures but actually reduces bio-age!
Boost NAD+, AMPK, reduce ill effects of igf-1 by DHEA, reduce mTOR by improved fasting and chemically fooled body, remove senescent and CaAKG by poorly understood gains, collectively list aging, and are sometimes compatible and independent. properly composed, they may be in useful parallel compose.
Done properly, you can reduce, likely stop aging, with some reversal. Enough to survive to Singularity2.0 in 5-20 years with E5 and Yamanaka factors.
The totality of Aging fix?
There are two distinct independent ways to ameliorate aging, One is the old way taught to many doctors namely shortening of telomere in cell division to Hayflick limit. Another is through DNA per cell. Most people under 100 will benefit most from DNA methods. Hayflick limit will become applicable eventually and hyperbaric oxygen at pressure, like divers stopping to prevent bends, elongate telomere, and this mode of aging can be addressed. Some people need that mode now and almost all benefit from high-pressure hyperbaric oxygen but may not need it.
Monetizing Benefits
I have a 150 pages book draft like my messages so far and would benefit from a win-win solution for print in your city or country as a book. Also some doctors you know will be interested in the aging practice, and be listed in this letter. For such patients, I provide experiences condensed and anonymized, from doctors, patients and merchants once every year and all needed knowledge on aging needed by the doctor. In both cases, you can quote a percent of my royalties and quoted percent of my fees from the patient, be like my agent in hour territory spending as much time you want, in addition to regular work, approaching persons of choice. This can be shared with your agents too in multi-level marketing. And no expenses till success, till then it is only quotations, and even then for making your own selling better.
Aging is a worldwide disease that afflicts everyone and can never be a shortage of patients, who only look for a guaranteed solution. Self-applications do that. My solutions are ideology, caste, creed, sex, in fact, any irrelevant metric independent.
Human expectations
https://www.facebook.com/watch/?v=5260638087326286
