hallmarks aging

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/bin/emss-55354-f0005.jpg

Quién se beneficiaría del texto hasta ahora y cómo

Comenzando después de esto, el resto del libro son ensayos breves sobre los productos químicos utilizados en los primeros capítulos del libro 1. En este punto, las preguntas en tu mente serían:

. ¿Qué es una descripción general de las lecturas hasta ahora?

Hasta ahora, creo que NAD+ boost, senolysis, methyl manipulations y las combinaciones de igf/DHEA son diferentes, efectivas y componibles hasta la singularidad 2.0 en 5 a 20 años. La singularidad tendrá reducciones de edad repetibles, lo que llevará a una vida indefinida. Consistirá en factores de Yamanaka y métodos E5 probados, probablemente basados ​​en señales que actúan como hormonas, mientras que todos los métodos de Singularity1 se basan en células.

Hay un cierre posible a partir del gráfico que simplifica el derivado de las características del envejecimiento. Estos son refuerzo de NAD+ y NO para vasos sanguíneos que cubren Sirutin1, metformina para AMPk y dosis bajas de rapamicina para mTOR. Igf+DHEA cubre el brazo izquierdo. Cubrimos las señas de identidad del envejecimiento.

Dos métodos más imaginables son fijar metilo y matar a los productores de SASP. SASP corrige eliminando la mayoría de las células senescentes por senólisis. Antes del envejecimiento, sucede de forma gratuita al permitir que el sistema inmunitario corrija los resultados de la apoptosis. El impulso de metilo y mitocondrias ocurre con CaAKG.

Entonces, el cóctel sugerido es NAD+ BOOST, IGF/DHEA. CaAKG, y Senolytics FISITIN + muchos polifenoles. Todos están filtrados a 4 químicos y es probable que no interactúen. El médico debe hacer frente a cualquier eventualidad. Ningún fármaco sugerido tiene una pequeña ventana de acción, por lo que se produce suficiente advertencia.

. ¿Qué es un plan para el consumidor hasta ahora?

Hay un número de médicos que cantan las alabanzas de su sistema. Como consumidor, cada uno es como un producto. Claramente, uno se beneficiaría más al hacer funciones componibles a la vez. Otros se pueden hacer más tarde. Esto debe aplicarse repetidamente. Eventualmente, se realizarán todos los métodos abordados. Entonces se pueden utilizar diferentes médicos. Entonces, el período bajo un médico se limita a un hilo de curación. Múltiples subprocesos pueden requerir médicos iguales o diferentes coordinados entre médico, consumidor, mi información por parte del consumidor.

. ¿Por qué entender los productos químicos?

Yo animo a Evert paciente a comprender los productos químicos para que las preguntas simples puedan resolverse sin la intervención del médico.

A diferencia de la medicina, las recomendaciones son en su mayoría suplementos y productos químicos seguros, con una historia empírica de 50 años. La única diferencia es la versión liposómica de cada uno para bailar en torno a los problemas de biodisponibilidad y los desastres malignos e inesperados que enfrenta Linus Pauling.

. ¿Por qué no soy un matón?

Todo lo que digo es una repetición de los mejores médicos que envejecen, con solo la adición de la forma de liposomas. Tan importante que abogo por la formulación de liposomas dirigida al paciente de la mayoría de los medicamentos. No puedo estar equivocado a menos que al menos un médico de alto nivel haya logrado imponer lo deseado en una prueba clínica de la FDA completada o en proceso, y crea que menos del 10% de la población necesita una solución de singularidad1.

. ¿Por qué no esperar?

Algunas partes del tratamiento completo benefician las actividades actuales y pueden adoptarse por motivos que no afectan al envejecimiento. Yo mismo me sometí a una prueba clínica y mi motivación no es el envejecimiento, sino la única forma de escapar de la devastación de varias enfermedades crónicas sin una solución alopática creíble mejor que mi riesgo adicional.

. quien debe esperar

Cualquiera que no esté consumido por enfermedades crónicas, cánceres o fragilidad sustancial. Debe tener una visión fiable (visión del paciente) de la muerte antes de la singularidad2.

. Qué garantías están disponibles como consumidor

No, y que no se está sometiendo a este tratamiento o basado en una recomendación negable no en papel, de parte mía o de cualquier médico de mi lista. Tendrás que firmar un papel diciendo eso.

. como entro

Elija un médico de mi lista, programe una cita y pregunte. Uno de los resultados de la primera cita es un formulario de inscripción.

. ¿Por qué debería pagar por ti?

La solución ganar-ganar-ganar requiere que cada uno haga algo por los demás, además de obtener beneficios.

Deberes

1. Paciente – pagar

2. Médico: pruebe al paciente para obtener beneficios

Proporcionar dirección dinámica

Continuar/pausar/cambiar tratamientos

3. Yo – agregar en privado

Recopile datos de los médicos de los pacientes y compre a los pacientes para desarrollar datos para ambos

Recopilar experiencias de pacientes

Recompensas

1. Paciente – incremento de vida segura

2. Médico – nuevo paciente

Continuar/pausar/cambiar tratamientos

3. Yo – tarifas por paciente

Comisión medible de compra dirigida por el paciente/médico

. ¿Cómo puedo ahorrar haciendo algo yo mismo?

No. Los datos MD requieren mucha experiencia en detección y control de daños. Aparte de la configuración, comparto datos de forma anónima. No existe un sistema privado descentralizado a bajo precio.

Who would benefit from text so far and how

Who would benefit from text so far and how

Starting after this,  rest of the book is short essays on chemicals used in the first  few chapters of book1. At this point, the questions in your mind would be:

. What is overview on readings so far

So far, I believe that NAD+ boost, senolysis, methyl manipulations and igf/DHEA combinations are each different, effective and composable till singularity2.0 in 5-20 years. Singularity will have repeatable age reductions, leading to indefinite life. It will consist of Yamanaka factors and tested E5 methods, likely based on signals acting like hormones, whereas all Singularity1 methods are cell based.

There is a closure possible from graph simplifying the one derived from hallmarks of aging. These are NAD+ boost and NO for blood vessels cover Sirutin1, Metformin for AMPk, and low-dose Rapamycin for mTOR. Igf+DHEA covers the left arm. We cover the hallmarks of Aging. 

Two more methods imaginable are fix methyl and kill SASP producers. SASP fixes by removing most of senescent cells by senolysis. Before Aging, it happens for free by letting immune system fix the results of apoptosis. The methyl and mitochondria boost happens with CaAKG.

So the suggested cocktail is NAD+ BOOST, IGF/DHEA. CaAKG, and Senolytics FISITIN + many poly phenols. All are filtered to 4 chemicals and likely will not interact. The MD must deal with any eventualities, No drug suggested has a small window of action, thus enough warning happens.

. What is a plan for the consumer so far

There are a number of doctors that sing the praises of their system. As a consumer, each is like a product. Clearly, one would benefit most by doing composable features at once. Others can done later. This must be applied repeatedly. Eventually every addressed method will be done. Different doctors may be used then. So the period under one doctor is limited to one cure thread. Multiple threads may require same or different doctors coordinated between doctor, consumer, my information by the consumer.

. why understand chemicals

Evert patient is encouraged by me to understand the chemicals so that simple questions can be solved without doctor intervention.

Unlike medicine, the recommendations are mostly supplements and safe chemicals, with empirical 50 year history. The only difference is liposome version of each to dance around bio-availability issues and evil unexpected disasters faced by Linus Pauling.

. Why am I not a thug

Every thing I say is repeat of a  top aging doctors, with only addition of liposome form. So important that I advocate patient directed liposome formulation of most drugs. I can not be wrong unless at least one top aging doctor managed to impose wished on completed or undergoing FDA clinical test, And believe that under 10% population needs singulaity1 fix.

. Why not wait

Some parts of the full treatment benefit current activities and can be adopted for non-aging reasons. I undergo a clinical test myself and my motivation is not aging but only way to escape devastation of several chronic diseases without a credible allopathic solution better than my extra risk.

. Who should wait

Anyone not consumed by chronic diseases, cancers or substantial frailty. You must have a reliable (patient view) of death before singularity2.

. What guarantees are available as a consumer

Non, and that you are not undergoing this treatment or based on deniable recommendation not on paper, from me or any doctor on my list. You will have to sign a paper saying that.

. How do I get in

Elect a doctor from my list, Set up an appointment and ask away. One result of 1^st appointment is a sign-up form.

. Why  should I pay for you

The win-win-win solution requires each doing some th9ing for the others, as well as getting benefits. 

Duties

1.     Patient – pay up

2.    Doctor – test the patient for benefits

Provide dynamic address

Continue/pause/change treatments

3.    Me – aggregate privately

Collect data from patient doctors and buying of patient to develop data for both

Collect patient experiences

Rewards

1.     Patient – safe life increment

2.    Doctor – new patient

Continue/pause/change treatments

3.    Me – per patient fees

Patient/doctor directed buy measurable commission

. How can I save by doing somethings myself

No. MD data requires lot of experience in damage detection and control. Apart from setv up, I share data anonymously.. There exists no decentralized private system cheaply.

The Aging Bible facebook

  The Aging Bible

Bible in the title is to address the dominant section of humans who know its impact and continuity changing as language changes - exactly as science I believe in, not in opium to simple jews. Long age requires dedicated perusal and active purchase and eating of supplements that may hurt or are involved in demand suppression conspiracies!

First draft

https://aaqg-arunarya.blogspot.com/2022/02/english-thank-you-0.html

I scooped by just a day! https://www.facebook.com/watch/?v=636133310954139&aggr_v_ids%5B0%5D=636133310954139&aggr_v_ids%5B1%5D=4721235164660523&notif_id=1642141059362314&notif_t=watch_follower_video&ref=notif The included link is of the greatest US free org called lifespan.io and shows top democratic and republican politicians agreeing with me

Bookstart

https://aaqg-arunarya.blogspot.com/2022/02/english-book.html

Book middle

https://aaqg-arunarya.blogspot.com/2022/02/english-goal.html

Book MEAT

https://aaqg-arunarya.blogspot.com/2022/02/intervention-meat-at-last.html

I have encountered tough problems in sending you mail, being censored by Facebook, even though very clean. Use current email or make a new one just for me, checked once a week. I will send my notes to you specifically. Use FB only for short pieces. You can ignore the address to forget me.

I come from soso framily. It has taken me 10 years to build age reduce. I try it. Thw first 3 chapters are given, there are many more. A good publisher in UAE can print a book cheap and do for all arab. Maybe you can help for a quote percentage of my royalty! Use where you are well, girl, and enrich us both. Book is more 150 pages.

Rest of pages

One subsection of half-page to three pages on these:

B3

Niacin

NR

NMN

NAD+

NaDH

AKG

TMG

Fisetin

Spermidine

Quertecin

apigenin

Flavonoid

Resveratrol

Pterostilbene

Sirtuin

AMPk

mTOR

HGH

IGF

Cancer

FOXO

Blue zone

The Aging Bible 1

  The Aging Bible

Bible in the title is to address the dominant section of humans who know its impact and continuity changing as language changes - exactly as science I believe in, not in opium to simple jews. Long age requires dedicated perusal and active purchase and eating of supplements that may hurt or are involved in demand suppression conspiracies!

First draft

https://aaqg-arunarya.blogspot.com/2022/02/english-thank-you.html

Bookstart

https://aaqg-arunarya.blogspot.com/2022/02/english-book.html

Book middle

https://aaqg-arunarya.blogspot.com/2022/02/english-goal.html

Book MEAT

https://aaqg-arunarya.blogspot.com/2022/02/intervention-meat-at-last.html

Rest of pages

One subsection of half-page to three pages on these:

B3

Niacin

NR

NMN

NAD+

NaDH

AKG

TMG

Fisetin

Spermidine

Quertecin

apigenin

Flavonoid

Resveratrol

Pterostilbene

Sirtuin

AMPk

mTOR

HGH

IGF

Cancer

FOXO

Blue zone

English thank you Facebook

 Thank you for accepting my request. I think we will work very well together with the expansion of trust, which is so needed from an angel that you will transform into. These are a few of your qualities.

Aging has been easy fraud for 4000 years, starting the oldest book known in 2000 b.c. that is a travelog of Gilgamesh in ancient Mesopotamia of adventures searching for an Aging cure. Not even one fraud has claimed the fountain of youth. Why? Even an idiot will try medicine before self-consumption!

Why isn't it a fraud this time?

The method has been proposed by several scientists who are not familiar with each other. It uses well-recognized international award methods. All are transparently available. Not even one scientist has refused to keep his method a secret. Such an approach is the reverse of fraud. All statements are always checked. Quick claims are ignored. Clearly, no one is being forced to declare anything and/or participate unwillingly. Everyone is free to declare anything and promote their causes in any way. The only limit is the permanent ignorance of any claim by an imbecile.

Who gets old and why?

Among all antiaging interventions, dietary interventions have shown the greatest potential. Calorie restriction, without undernourishing the individual, slows down the aging process and lengthens the average and maximum life in animals of various origins. Repeated reports say that the restriction of food intake in rats extended the half and maximum life and decreased the occurrence and severity of chronic diseases. Subsequent findings emphasized that calorie restriction has effects on lifespan in a wide range of organisms. The positive effects of caloric restriction in humans have also been shown in many studies. Calorie restriction while maintaining adequate nutrition has beneficial effects such as protection against the development of obesity, cardiovascular disease, hypertension, and cancer. In a controlled study, caloric restriction with high levels of physical activity showed a decrease in blood pressure, body weight, serum cholesterol levels, insulin levels, and other anthropometric and physiological parameters. The mechanisms by which calorie restriction induces life-prolonging properties are not fully understood, but the following four potential target pathways have been suggested: activation of AMP protein kinase (AMPK) and sirtuins, inhibition of growth factor insulin-like-1 (IGF-1) signaling and mammalian target of rapamycin (mTOR) inhibition by rapamycin. These pathways are the main hypothesized mechanisms of action of caloric restriction that control cell growth, mitochondrial function, and autophagy directly or indirectly. However, despite the proven benefits of caloric restriction, it is a difficult technique to use successfully in humans, as it is challenging to apply the treatment long-term, requiring a high level of determination and self-control. This paradox led to the discovery of compounds that mimic the outcome of caloric restriction on health and life expectancy without actual restriction in caloric intake. These compounds were called "calorie restriction mimetics" (CRMs).

Writing rational aging recommendations is my mission and explains why I seek out a doctor/nurse on my team to argue effects as devil's advocate for my research. Beyond the three here and metformin even without TAME (4th), I expect TRIIM-X to end up as 5, low dose rapamycin as 6, and much more as E5 is not public yet. The most stupid idea is to compose the best of each or try them all sequentially, individually, like 5 Pandavas or 6 wives.

The three theories, determined by me to be independent, thus composable, are NAD+ boost by NMN and NO from resveratrol according to Dr. Sinclair (and argnin by itself); Senolysis through fisetin according to Dr. de Grey; and CaAKG (+ayurveda +vitamins) according to Dr. Kennedy. The FDA essentially oversees the safety and efficacy of chemicals—healthy for drugs but useless for drugs and me—critical chemicals like new aging-related chemicals. Just for these, I make referrals differently, out of ethics, not law.

My main improvement is to sidestep questions about bioavailability and drug delivery by using liposome forms of all chemicals (except NAD+ for BBB entry). Liposomes eliminate necessary medical services and work even better than injections because they bypass cells.

Safety is assumed due to the safety of low concentrations of

1 Element of many fruits and vegetables with no known credible hazards

2 At least 20-30 years of safe history as a drug or supplement

3 GRAS status in US law

4 Chemical name of a body compound or intermediate

Therefore, NMN is derived from n. 4, Fisetin from no. No. 1, CaAKG from no. #4, arginine and resveratrol from #4. ° 2. This is the personal safety and not the safety of the community, the only one for which such arguments can be made. For random communities, I recommend waiting for the FDA, unless the risk of inaction is greater than compensation aging. position

The effectiveness stems from the fact that I consider these three developers to be like double Noble award winners defending this thread. Joint efficacy occurs from the apparent independence of the threads, NAD+ increases are needed and decrease empirically. De Grey's thread arises from the elimination of harmful senescent cells that produce SASP and CD38 in particular, buying immunity against cancer as a secondary benefit. The AKG thread is not clear, it may work due to the effective accounting of methylation marks, which prolongs cell life. Security does not end here.

There are unknown dangers from the size of the dose and interactions with other parts of these threads, and completely different medications prescribed for other diseases that coincide with aging. These are precisely circumstances in which the patient is alone anyway! Common sense says that if chemicals are safe in low doses and edible, they are likely to be safe in higher doses unless they are unnatural or registered.

I'm a big believer in Bayesian statistics and therefore suspicious of FDA clinical trials on new chemicals with no history of use. Most drugs approved after 2000 are cancer suspects! I think a doctor or a vaccine solves a problem by creating more instances and thus best avoided unless really necessary and a healthy disrespect to new chemicals but not food.

With my thought, a particular burden was lifted after 2 months of self-assessment. I can now advise the family to try if you are as bothered with chronic illness as I am, as long as the risks are higher anyway. My work and registered risks have not collapsed until now. People who don't see death hanging there anyway, or a decrepit life, should expect the blessings of the FDA.

What is chemical aging?

The immense contribution is from Sinclar. Simple and useless except for validation of de-aging methods. Every human cell has its DNA in a sac called a nucleolus. It specializes in the exact type of cell through an epigenetic covering of DNA by turning genes on and off using switches containing methyl groups. Some switches are permanently on or off depending on the expressed specialization. Others can be dynamically turned on or off depending on the protein being made.

 Genetics and epigenetics make DNA an information-carrying molecule that can deliver some proteins through mRNA copying. Over time, methyl groups lose their elasticity, and a cell has more methyl groups that can no longer turn on and off. Methyls are part of the CpG islands, the C sugar being a phosphate bond with the next G sugar, a microscope can read the number of such methyl groups. The AI ​​can read the list to calculate the biological age of the cell! Validation stems from the age equality of cells in all parts of the human body and the predictable changes in all animals in Eutheria. Not only does evolution age all animals by the same method, but the different details of aging are also species-specific. No fraud can non-fraudulent claim this and escape scrutiny!

Events in 2022

The most important to me, listed in Radom order, are

a. end of my clinical self-experiment

B. near the end of the partial self-experiment of the mother and sister

C. expected end of TRIIM-X and my start of HGH-1 with diabetes fix

D. end of MIB-626, thus better boost of NAD+ and NO.

me. The success of the Sinclair aging test for mDNA and GrimAge

The whole field of Aging

1. Dr. de Grey, for presenting/developing an engineering approach to the problem of aging and senolytics

2. Dr. Sinclair, for NMN and Theory of Aging 2019

3. Dr. Yamanaka for inventing the Yamanaka factors and iPSC.

4. Dr. Horvath for mDNA/GrimAge and the applicability of methylation in Eutherian

5. Drs. Conboys for early heterochronic parabiosis and not young blood but simple albumin works

6. Dr. Fahi for TRIIM and TRIIM-X

The number of endorsed supplements for aging increases every day. A stupid way is to try a random permutation subset of the supplements, hoping there is no interaction. This is done by many in India, treating illnesses and cures as if they were buying a product, usually with independent effects. I have contempt for these consumers and call them stupid meta-assholes, not just once but repeatedly. Two cures or drugs can be combined only if the prescriber is a single registered doctor or the interactions are accurately analyzed and the person performs a self-imposed clinical test, it is essential that the fssai/2012 know this! Unfortunately, there is no credible data like that, side effect website indications are unreliable, and if written guarantees are sought, most doctors are smart enough to use legal language that can include all side effects. known/unknown side effects so extensive that any rational patient would never try that drug or supplement! Between lawyers and doctors, the patient is screwed!

Another stupidity is the sequential attempts of the doctors until an applicable one is found. It works enough to keep the method alive, but the crossover effects are deadly. I believe in the doctors above, that is, in the effectiveness of the recommendations. But how to compose, including deciding who to compose and what to do with normal illnesses.

I am probably jumping the lake - that my age fix works, will work when ready, and I live to then. Seems to be working, now 12 months in 18, stranger guess my age 15-20 year lesser, DNAm test n may, 23. Likely your age matters not, and I will need a beautiful person like you to chase, your country prices I can afford, and local help you can be my agent for.

update: I am probably jumping the lake - that my age fix works, will work when ready, and I live to then. Seems to be working, now 12 months in 18, stranger guess my age 15-20 year lesser, DNAm test in may, 23. Likely your age matters not, and I will need a beautiful person like you to chase, your country prices I can afford, and local help you can be my agent for.

English thank you 1

 Aging has been easy fraud for 4000 years, starting the oldest book known in 2000 b.c. that is a travelog of Gilgamesh in ancient Mesopotamia of adventures searching for an Aging cure. Not even one fraud has claimed the fountain of youth. Why? Even an idiot will try medicine before self-consumption!

Why isn't it a fraud this time?

The method has been proposed by several scientists who are not familiar with each other. It uses well-recognized international award methods. All are transparently available. Not even one scientist has refused to keep his method a secret. Such an approach is the reverse of fraud. All statements are always checked. Quick claims are ignored. Clearly, no one is being forced to declare anything and/or participate unwillingly. Everyone is free to declare anything and promote their causes in any way. The only limit is the permanent ignorance of any claim by an imbecile criminal.

The second immensity is age reversal i.e. a fountain of youth. And that leads to the 1000-year life i.e. wish death, with under 1-year hospitalization and 1000-year healthspan first. It happens in 5-20 years and you can live that long with today's technology. All social implications of abolishing death have been answered elsewhere and this book worries only about technology for now.

Who gets old and why?

All life is cellular with DNA in it. The DNA double helix can be thought of as an Information-bearing molecule with an epigenetic layer. Genetics is to medicine as mathematics is to physics!

Among all antiaging interventions, dietary interventions have shown the greatest potential, even beyond exercise. Calorie restriction, without undernourishing the individual, slows down the aging process and lengthens the average and maximum life in animals of various origins. Repeated reports say that the restriction of food intake in rats extended the half and maximum life and decreased the occurrence and severity of chronic diseases. Subsequent findings emphasized that calorie restriction has effects on lifespan in a wide range of organisms. The positive effects of caloric restriction in humans have also been shown in many studies. Calorie restriction while maintaining adequate nutrition has beneficial effects such as protection against the development of obesity, cardiovascular disease, hypertension, and cancer. In a controlled study, caloric restriction with high levels of physical activity showed a decrease in blood pressure, body weight, serum cholesterol levels, insulin levels, and other anthropometric and physiological parameters. The mechanisms by which calorie restriction induces life-prolonging properties are not fully understood, but the following four potential target pathways have been suggested: activation of AMP protein kinase (AMPK) and sirtuins, inhibition of growth factor insulin-like-1 (IGF-1) signaling and mammalian target of rapamycin (mTOR) inhibition by rapamycin. These pathways are the main hypothesized mechanisms of action of caloric restriction that control cell growth, mitochondrial function, and autophagy directly or indirectly. However, despite the proven benefits of caloric restriction, it is a difficult technique to use successfully in humans, as it is challenging to apply the treatment long-term, requiring a high level of determination and self-control. This paradox led to the discovery of compounds that mimic the outcome of caloric restriction on health and life expectancy without actual restriction in caloric intake. These compounds were called "calorie restriction mimetics" (CRMs).

Writing rational aging recommendations is my mission and explains why I seek out a doctor/nurse on my team to argue effects as devil's advocate for my research. Beyond the three here and metformin even without TAME (4th), I expect TRIIM-X to end up as 5, low-dose rapamycin as 6, and much more as E5 is not public yet. The most stupid idea is to compose the best of each or try them all sequentially, individually, like 5 Pandavas or 6 wives.

The three theories, determined by me to be independent, thus composable, are NAD+ boost by NMN and NO from resveratrol according to Dr. Sinclair (and argnin by itself); Senolysis through fisetin according to Dr. de Grey; and CaAKG (+ayurveda +vitamins) according to Dr. Kennedy. The FDA essentially oversees the safety and efficacy of chemicals—healthy for drugs but useless for drugs and me—critical chemicals like new aging-related chemicals. Just for these, I make referrals differently, out of ethics, not law.

My main improvement is to sidestep questions about bioavailability and drug delivery by using liposome forms of all chemicals (except NAD+ for BBB entry). Liposomes eliminate necessary medical services and work even better than injections because they bypass cells.

Safety is assumed due to the safety of low concentrations of

1 Element of many fruits and vegetables with no known credible hazards

2 At least 20-30 years of safe history as a drug or supplement

3 GRAS status in US law

4 Chemical name of a body compound or intermediate

Therefore, NMN is derived from n. 4, Fisetin from no. No. 1, CaAKG from no. #4, arginine and resveratrol from #4. ° 2. This is the personal safety and not the safety of the community, the only one for which such arguments can be made. For random communities, I recommend waiting for the FDA, unless the risk of inaction is greater than compensation aging. position

The effectiveness stems from the fact that I consider these three developers to be like double Noble award winners defending this thread. Joint efficacy occurs from the apparent independence of the threads, NAD+ increases are needed and decrease empirically. De Grey's thread arises from the elimination of harmful senescent cells that produce SASP and CD38 in particular, buying immunity against cancer as a secondary benefit. The AKG thread is not clear, it may work due to the effective accounting of methylation marks, which prolongs cell life. Security does not end here.

There are unknown dangers from the size of the dose and interactions with other parts of these threads, and completely different medications prescribed for other diseases that coincide with aging. These are precisely circumstances in which the patient is alone anyway! Common sense says that if chemicals are safe in low doses and edible, they are likely to be safe in higher doses unless they are unnatural or registered.

I'm a big believer in Bayesian statistics and therefore suspicious of FDA clinical trials on new chemicals with no history of use. Most drugs approved after 2000 are cancer suspects! I think a doctor or a vaccine solves a problem by creating more instances and thus best avoided unless really necessary and a healthy disrespect to new chemicals but not food.

With my thought, a particular burden was lifted after 2 months of self-assessment. I can now advise the family to try if you are as bothered with chronic illness as I am, as long as the risks are higher anyway. My work and registered risks have not collapsed until now. People who don't see death hanging there anyway, or a decrepit life, should expect the blessings of the FDA.

What is chemical aging?

The immense contribution is from Sinclar. Simple and useless except for validation of de-aging methods. Every human cell has its DNA in a sac called a nucleolus. It specializes in the exact type of cell through an epigenetic covering of DNA by turning genes on and off using switches containing methyl groups. Some switches are permanently on or off depending on the expressed specialization. Others can be dynamically turned on or off depending on the protein being made.

 Genetics and epigenetics make DNA an information-carrying molecule that can deliver some proteins through mRNA copying. Over time, methyl groups lose their elasticity, and a cell has more methyl groups that can no longer turn on and off. Methyls are part of the CpG islands, the C sugar being a phosphate bond with the next G sugar, a microscope can read the number of such methyl groups. The AI ​​can read the list to calculate the biological age of the cell! Validation stems from the age equality of cells in all parts of the human body and the predictable changes in all animals in Eutheria. Not only does evolution age all animals by the same method, but the different details of aging are also species-specific. No fraud can non-fraudulent claim this and escape scrutiny!

Events in 2022

The most important to me, listed in Radom order, are

a. end of my clinical self-experiment

B. near the end of the partial self-experiment of the mother and sister

C. expected end of TRIIM-X and my start of HGH-1 with diabetes fix

D. end of MIB-626, thus better boost of NAD+ and NO.

me. The success of the Sinclair aging test for mDNA and GrimAge

The top whole field of Aging, each like a double Nobel winner

1. Dr. de Grey, for presenting/developing an engineering approach to the problem of aging and senolytics

2. Dr. Sinclair, for NMN and Theory of Aging 2019

3. Dr. Yamanaka for inventing the Yamanaka factors and iPSC.

4. Dr. Horvath for mDNA/GrimAge and the applicability of methylation in Eutherian

5. Drs. Conboys for early heterochronic parabiosis and not young blood but simple albumin works

6. Dr. Fahi for TRIIM and TRIIM-X

The number of endorsed supplements for aging increases every day. A stupid way is to try a random permutation subset of the supplements, hoping there is no interaction. This is done by many in India, treating illnesses and cures as if they were buying a product, usually with independent effects. I have contempt for these consumers and call them stupid meta-assholes, not just once but repeatedly. Two cures or drugs can be combined only if the prescriber is a single registered doctor or the interactions are accurately analyzed and the person performs a self-imposed clinical test, it is essential that the fssai/2012 know this! Unfortunately, there is no credible data like that, side effect website indications are unreliable, and if written guarantees are sought, most doctors are smart enough to use legal language that can include all side effects. known/unknown side effects so extensive that any rational patient would never try that drug or supplement! Between lawyers and doctors, the patient is screwed!

Another stupidity is the sequential attempts of the doctors until an applicable one is found. It works enough to keep the method alive, but the crossover effects are deadly. I believe in the doctors above, that is, in the effectiveness of the recommendations. But how to compose, including deciding who to compose and what to do with normal illnesses.

update:  I am probably jumping the lake - that my age fix works, will work when ready, and I live to then. Seems to be working, now 12 months in 18, stranger guess my age is 15-20 years lesser, DNAm test n may, 23. Likely your age matters not, and I will need a beautiful person like you to chase, your country prices I can afford, and local help you can be my agent for. I am probably jumping the lake - that my age fix works, will work when ready, and I live to then. Seems to be working, now 12 months in 18, stranger guess my age is 15-20 years lesser, DNAm test n may, 23. Likely your age matters not, and I will need a beautiful person like you to chase, your country prices I can afford, and local help you can be my agent for.