English new aging 2024

Consolidated Compact Aging Theory – 1

I am not a doctor despite my 24 years in biology. Still, I am sharper than all not specializing in aging subjects for a very simple reason: All age and if they knew at all, you would see many looking far younger and/or talking about the chemicals, and/or having a scientific theory of aging! That aging defeat is around the corner despite subhuman criminals proclaiming so for 4000 years since Mesopotamians founded written records. It has happened very recently, the history is boring, except for how to detect the brilliant ones, without using force, always the basis of poor states and philosophers. You as every other reader must develop a litmus test as I did. Everyone is allowed to lie to their best, unintentionally or otherwise, the litmus test flunks them, and every moron is allowed just one error, except that no intent proof (burden criminal) is needed for one more chance. 

My litmus test is simple

1. Recommended by someone who has passed the test

2. Or/and publicly subscribes to a theory that explains my simple axiom observations

3. Or/and provides a theory consistent with hallmarks of aging

My axiom observations

Simple universal observations are below. Unlike every other researcher read, these are like axioms, not requiring any expertise.

1. No one is born aged despite the ages of the parents

2. No one is born with strange DNA despite the health of parents

3. Nothing special happens to induce old age. No one has ever found vastly different processes in old.

4. Predation of older animals does not introduce old age in predators. Nor predation of young animals reduces the age of the predator.

1 and 2 Imply zeroing of age and saving the DNA state from a young even as the real DNA suffers age abuse. Zeroing is a constraint on the aging clock.

Simple anatomy

Any eucaryotic or human body is made of many cells only. Any evolutionary success is inherited by all subsequent branches unless they die out from non-use. A cell has many organelles, we are interested in four – nucleolus, mitochondria, lysosomes, and ribosomes.

Professor Sinclair of information theory fame is consistent with all my axiomatic observations if they apply. It is incomplete.

Dr. Blagosklonny’s Hyperfunction theory is a consistent shell around Dr. Sinclair. My subpart can also be included as a hyperfunction to execute independently in parallel. All aging processes cause death in the end, i.e. each parallel hyperfunction terminates in death. Avoiding aging must imply delaying each alternative.

Every hyperfunction operates to improve processes at a good speed. But after adulthood, the speed is not needed and the very processes become evil. It is like cars on the highway, After exit, highway speeds become fatal. O3 says nothing extraordinary happens. O4 says aging is not a physical entity.

Blagosklonny’s theory is wishy-washy and absent what specific hyperfunctions exist,. Here is how I found Dr, Sinclair. There is a paper defining aging titled “Hallmarks of Ageing”

1. The tip of the diagram matches only one Sinclair information theory of aging.

2. Dr. Sinclair was led to his theory in a scientific empirical manner.

3. Not agreeing with him removes some explanations of axioms

4. I do not have what it takes to do a PhD at MIT.

Only he and Dr. Austad have managed to age back and forth the age of a mouse. That is why I consider their work a subset. The applicable parts below will not be fully fixed by cell DNA fixes.

Strategies for reducing aging

All these require de-ageing

1. NAD+ boost

2. Work on DNA

3. Work on mitochondria

4. Achieve senolysis

5. Lengthen telomeres

6. Fix brain losses

7. Reenergise immune system

8. Fix heart

9. Starve cancers

10. elongate telomeres, by telomerase, HBOT etc

11. Fix skin with collagen hyaluronic

6,7,8,9,10 eliminate 99% of the current reasons for death. Diabetes, liver, kidney, etc are auto-fixed in cellular regeneration.

Some strategies happen automatically from fixes of Yamanaka factors genetically which need activation, by the osk part of the oskm quad, fed intermittently in low dosage. The major, as significant as the discovery of DNA, is the proof by Sinclair in mid-2023 that shows the de-aging effects of six cocktails of simple medicine. To let significance sink in, the pill will be a meager cost, a low-molecular nongenetic FDA-approved drug, and universally available. But that is not enough. The Japanese have outdone even Yamanaka and have discovered HKDC1 protein that de-ages mitochondria and lysosomes and hence kills most diseases of age.

A consequence of both the Sinclair cocktail and HKDC1 is that all the problems are fixed in Cell nucleolus, mitochondria, and lysosomes. The only one that remains is telomere which may/may not be fixed. In any case, health span extension, with no end-of-life slow torture is here.

Collection of steps to meet strategies

o. The first part is DNA aging, I cannot do intermittent fasting given my diabetes and CABG. The Stanfield way through exercise and muscle expansion is still open to my tweaks.

1. Part of aging is telomere shortening. Telomerase can fix it. HBOT tweaks are also important with vanity effects.

2. Fixing the age of the Cell part does nothing for the brain. One must worry about Alzheimer’s and Parkinson’s, in fact, aged forgetfulness. Very few aging molecules cross the blood-brain barrier BBB. That said, de-ageing works in the brain too, and some lost memories are restored. The brain becomes younger without losing memories! So maybe the issue is a red herring.

3, Around 60 years of age, new white cells cease. By 80, existing ones are mostly gone! Opportunistic infections move in. These are distinct problems not necessarily fully fixed by the reduced age of Cells.

4 Most important is finding cues for both mitochondria and Lysosomes. HKDC1 works for both, say the Japanese who predict a cheap pill within 3 years. They predict a cheap pill within 3 years. They have found a 20-year reduction in age a few times, By my theory, other hyperfunctions will be important by then and HKDC1 is not sufficient for care beyond like 60 years.

So I adopt and recommend NAD+ care, HKDC1,

and other hyperfunctions care as well like the immune system.

Warning: biology is a science in which logical suggestion does not often work, empirical experiments are needed. The top example is age reduction by parabiosis, which suggests a blood swap but the latter fails! Science requires mechanisms but even minor deductions may fail! It is a fact that medicines that work for some may not work for others,

Knowing a scientific reason why FDA clinical tests are the gold standard in the world indicates that both advertisement and episodic damage greatly exceed that from lack of personalized medicine and FDA results make sense only under smart MD care finding great care is very hard in India due to the MD load and one is reduced to close relatives, allied subject-experienced teachers, or expensive doctors. My own experience is based as follows.

1. Any new medicine is added after a month’s gap. In the end, one decides to keep or discard it. Evil may strike for reasons unrelated to chemicals like the cost, honesty of brand, etc

2. Why one month: earth and evolution are possible only when organic reactions happen fast only in the presence of catalysts which are not common. That allows enough rate without a meaningful error rate. This means that generally, the medicine’s organic chemicals would not act in pairs.

3. Further, guarantee self-testing to determine if the chemical is a vitamin or like, say CoQ10.

4. Finally, bravery comes from certain consequences of inaction – degrading life.

5, Write up (hereafter 15 months) Without minor or major logic, empirical results on self are described next.

These are all suggested by the discussion above, modified by experience.

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