Aging is a disease far worse than others.
I got involved in a project that helps my parents now and me eventually, as will it, you whenever – immortality is not sought by anyone but religious insane; however neologism of amortality i.e. pain-free life and only short painful episodes at the end of 90-100 years of robust life with outside chance of being around whensingularity comes and being able to afford it; that is a rational and doable wish if careful and adventurous.
I got involved in a project that helps my parents now and me eventually, as will it, you whenever – immortality is not sought by anyone but religious insane; however neologism of amortality i.e. pain-free life and only short painful episodes at the end of 90-100 years of robust life with outside chance of being around whensingularity comes and being able to afford it; that is a rational and doable wish if careful and adventurous.
I am
personally ecstatic at having discovered a defensible and disc losable
technique for adding robust
10 years to my life through ECP , metformin, Niagen and coQ10; with blood
transfusion and rapamycin as work to be done. Even more ecstatic in finding
a evidence based explanation for an empirically observed truth – a physician is
best possible scientist in all acute illnesses; but awful
in chronic management. My Donald Trump argument against fake chronic evidence claims.
I have very
slowly but very definitely improved to the point that while very poor in long interactions
in person, I have clear episodes which can be joined together for certain money
making professions, namely software and authorship. That is the way for me to
go, even when my parents are no longer there and I have to face the world
without kids. I am blessed to have great sisters and wonderful in-laws.
Briefly, I can survive well without parents or kids, never mind my TBI disabilities
with help of SS, shuck able soon!
Proof for Niagen
Niagen is a proven(*) anti-oxidant chemical for anti-aging, being an active noflushing form of vitamin B3.
1) it is sold as nutraceutal to avoid FDA to escape long tests and government-big-brotherism (sales by prescription only) but loses scientific scrutiny standardized for others. Nor can inventors prevent others, or studies with possible conflict-of-interest.
2) University of Iowa proof
Proof for ECP
ECP was invented at Harvard as technique to assist heart patients but was ignored by stenting popularity. It went to china and emerged with improved machines and flurry of medical papers since 2000. It is NOT known in India, but it can greatly help patients and elderly!
Enhanced External Counter Pulsation (EECP) or non-trademarked ECP is performed as a non-invasive treatment to lower the number and intensity of angina episodes. Treatment is administered by a machine through three pairs of external inflatable cuffs that are applied around the lower legs, upper legs and buttocks; properly synchronized with heart. It is proprietary but in eyes of this comed doctor, is equaled by others.
Aetna (huge medical insurance co, USA) considers a course of up to 35 sessions of external counterpulsation (ECP) medically necessary for members who meet both of the following criteria: A) Members with disabling chronic stable angina (New York Heart Association Class III or Class IV angina) (see Appendix); and B) Members are refractory to maximum medical therapy and not readily amenable to surgical intervention such as percutaneous transluminal coronary angioplasty (PTCA) or cardiac bypass due to any of the following: Their condition is inoperable; or They are at high-risk of operative complications or post-operative failure; or Their coronary anatomy is not readily amenable to such procedures; or They have co-morbid states that create excessive risk.
There is no proven benefit to extending a course of ECP beyond 35 sessions.
Proof for coQ10
Anti-oxidant co-enzyme Q10 is prescribed by acute heart medical doctors to improve strength and reduce the small but present aide-effects of statin drugs. Aging - early study suggests that a combination of CoQ10 and other antioxidants and minerals may improve skin roughness and fine wrinkles. Further research is needed to understand CoQ10's role in skin aging.In Alzheimer's disease - There is some evidence that idebenone, a man-made compound similar to CoQ10, may benefit people with Alzheimer's disease. However, the effect of CoQ10 itself is unclear.
CoQ10 is sold in many forms with differing rationalization and claims of effectivenes. There is one form that provably towers above all - mitoq, hundreds of times better than coQ10 and also very expensive. There is NO mitoq like form of niagen on market today.
As comed doctor, I can vouch for increased energy feeling in me. There is a vicious cycle - exercise (critical) raises effort-capability, but that capability requires increased energy! CoQ10 helped me break the cycle!
Proof for metformin
Metformin is a cheap salt safe enough to be used for diabetes. It extends patient lives over insulin or insulin progenitors. As comed doctor, I think insulin is contraindicated for long use in elderly patients. It is like IGF-1. Also I believe that medically unnecessary metformin has no evil side effects mostly and will extend the robust lifespans of elderly.
Metfomin requiresa fair amount of work as its diabetic use is licensed.
Metformin is known by type-2 diabetics. Investigation into its mechanism of action not only explained its primary use, but also other things for good and bad, good being anticancer and antiage properties, principal bad being overweightness.
The most well-known mechanism of metformin action, one of the most commonly prescribed antidiabetic drugs, is AMPK adenosine monophosphate-activated protein kinase activation; however, recent investigations have shown that adenosine monophosphate-activated protein kinase-independent pathways can explain some of metformin's beneficial metabolic effects as well as undesirable side-effects. Such novel pathways include induction of mitochondrial stress, inhibition of mitochondrial shuttles, alteration of intestinal microbiota,
suppression of glucagon signaling, activation of autophagy, attenuation of inflammasome activation, induction of incretin receptors and reduction of terminal endoplasmic reticulum stress. Together, these studies have broadened our understanding of the mechanisms of antidiabetic agents as well as the pathogenic mechanism of diabetes itself. The results of such investigations might help to identify new target molecules and pathways for treatment of diabetes and metabolic syndrome, and could also have broad implications in diseases other than diabetes.
Thepaper presents applications in antiage and anticancer applications. CDC is evaluating the drug since 2016 and there are lot of anecdotal stories of being beneficial. Given the minor effects of mild overdosing, a doctor-mediated self-experiment is foolhardy but not fully arguable against. Certainly diabetics like me get full benefits at no additional cost, just need to be more aggressive on insulin.
Proof for Transfusion
Proof for rapamycin
There exists well-funded development trajectory from cancer applications.
Extrapolating from mice
Mice are excellent for testing effects. For cellular products assuming identical effects, the effects can be scaled up by constancy of per kg. weight, hence by raw weight in pre-human testing and estimating effects, to closer biomodel like primates. In USA, 10% is used as threshold of damage, meaning that 10% of mice damage is considered to be the safe upper limit by weight, So 10,000 mg safe limit for mice translates to 1000 mg limit for human of average weight. In that sense Niagen is very safe at all therapeutic levels. However +ve results may require scaling up of equivalent levels too.
Proof for Niagen
Niagen is a proven(*) anti-oxidant chemical for anti-aging, being an active noflushing form of vitamin B3.
1) it is sold as nutraceutal to avoid FDA to escape long tests and government-big-brotherism (sales by prescription only) but loses scientific scrutiny standardized for others. Nor can inventors prevent others, or studies with possible conflict-of-interest.
2) University of Iowa proof
Proof for ECP
ECP was invented at Harvard as technique to assist heart patients but was ignored by stenting popularity. It went to china and emerged with improved machines and flurry of medical papers since 2000. It is NOT known in India, but it can greatly help patients and elderly!
Enhanced External Counter Pulsation (EECP) or non-trademarked ECP is performed as a non-invasive treatment to lower the number and intensity of angina episodes. Treatment is administered by a machine through three pairs of external inflatable cuffs that are applied around the lower legs, upper legs and buttocks; properly synchronized with heart. It is proprietary but in eyes of this comed doctor, is equaled by others.
Aetna (huge medical insurance co, USA) considers a course of up to 35 sessions of external counterpulsation (ECP) medically necessary for members who meet both of the following criteria: A) Members with disabling chronic stable angina (New York Heart Association Class III or Class IV angina) (see Appendix); and B) Members are refractory to maximum medical therapy and not readily amenable to surgical intervention such as percutaneous transluminal coronary angioplasty (PTCA) or cardiac bypass due to any of the following: Their condition is inoperable; or They are at high-risk of operative complications or post-operative failure; or Their coronary anatomy is not readily amenable to such procedures; or They have co-morbid states that create excessive risk.
There is no proven benefit to extending a course of ECP beyond 35 sessions.
Proof for coQ10
Anti-oxidant co-enzyme Q10 is prescribed by acute heart medical doctors to improve strength and reduce the small but present aide-effects of statin drugs. Aging - early study suggests that a combination of CoQ10 and other antioxidants and minerals may improve skin roughness and fine wrinkles. Further research is needed to understand CoQ10's role in skin aging.In Alzheimer's disease - There is some evidence that idebenone, a man-made compound similar to CoQ10, may benefit people with Alzheimer's disease. However, the effect of CoQ10 itself is unclear.
CoQ10 is sold in many forms with differing rationalization and claims of effectivenes. There is one form that provably towers above all - mitoq, hundreds of times better than coQ10 and also very expensive. There is NO mitoq like form of niagen on market today.
As comed doctor, I can vouch for increased energy feeling in me. There is a vicious cycle - exercise (critical) raises effort-capability, but that capability requires increased energy! CoQ10 helped me break the cycle!
Proof for metformin
Metformin is a cheap salt safe enough to be used for diabetes. It extends patient lives over insulin or insulin progenitors. As comed doctor, I think insulin is contraindicated for long use in elderly patients. It is like IGF-1. Also I believe that medically unnecessary metformin has no evil side effects mostly and will extend the robust lifespans of elderly.
Metfomin requiresa fair amount of work as its diabetic use is licensed.
Metformin is known by type-2 diabetics. Investigation into its mechanism of action not only explained its primary use, but also other things for good and bad, good being anticancer and antiage properties, principal bad being overweightness.
The most well-known mechanism of metformin action, one of the most commonly prescribed antidiabetic drugs, is AMPK adenosine monophosphate-activated protein kinase activation; however, recent investigations have shown that adenosine monophosphate-activated protein kinase-independent pathways can explain some of metformin's beneficial metabolic effects as well as undesirable side-effects. Such novel pathways include induction of mitochondrial stress, inhibition of mitochondrial shuttles, alteration of intestinal microbiota,
suppression of glucagon signaling, activation of autophagy, attenuation of inflammasome activation, induction of incretin receptors and reduction of terminal endoplasmic reticulum stress. Together, these studies have broadened our understanding of the mechanisms of antidiabetic agents as well as the pathogenic mechanism of diabetes itself. The results of such investigations might help to identify new target molecules and pathways for treatment of diabetes and metabolic syndrome, and could also have broad implications in diseases other than diabetes.
Thepaper presents applications in antiage and anticancer applications. CDC is evaluating the drug since 2016 and there are lot of anecdotal stories of being beneficial. Given the minor effects of mild overdosing, a doctor-mediated self-experiment is foolhardy but not fully arguable against. Certainly diabetics like me get full benefits at no additional cost, just need to be more aggressive on insulin.
Proof for Transfusion
Could the elixir of youth be as simple as a protein found in young blood? In recent years, researchers studying mice found that giving old animals blood from young ones can reverse some signs of aging, and last year one team identified a growth factor in the blood that they think is partly responsible for the antiaging effect on a specific tissue—the heart. Now, that group has shown this same factor can also rejuvenate muscle and the brain.
If parbiosis works, one does not have to unethically extract blood from young humans. In vitro RBC production from stem cells could represent an alternative to classic transfusion products. Until now the clinical feasibility of this concept has not been demonstrated. We addressed the question of the capacity of cultured RBCs (cRBCs) to survive in humans. By using a culture protocol permitting erythroid differentiation from peripheral CD34(+) HSC, we generated a homogeneous population of cRBC functional in terms of their deformability, enzyme content, capacity of their hemoglobin to fix/release oxygen, and expression of blood group antigens. We then demonstrated in the nonobese diabetes/severe combined immunodeficiency mouse that cRBC encountered in vivo the conditions necessary for their complete maturation. These data provided the rationale for injecting into one human a homogeneous sample of cRBCs generated under good manufacturing practice conditions and labeled. The level of these cells in the circulation 26 days after injection was between 41% and 63%, which compares favorably with the reported half-life for native RBCs. Their survival in vivo testifies globally to their quality and functionality. These data establish the proof of principle for transfusion of in vitro-generated RBCs and path the way toward new developments in transfusion medicine.
Apart from ethics and administration, cell stems have guaranteed no-side-effects from compatibility.
Apart from ethics and administration, cell stems have guaranteed no-side-effects from compatibility.
Rapamycin is a chemical produced by soil bacteria. In lab experiments, the chemical has significantly lengthened the lifespan of yeasts, worms, fruit flies and mice. It's currently being tested in pet dogs. If this trial is successful, rapamycin may then be tested in humans. Rapamycin seems to work by inhibiting a protein known as mTOR.
The goal of anti-aging techniques varies. For some researchers, the main objective is to prolong life. For others, the aim is not so much to extend life but instead to ward off those diseases that are more common in old age.
Rapamycin is useful in cancers. BACKGROUND:
METHODS AND FINDINGS:
Based on preclinical evidence that phosphatase and tensin homolog deleted on Chromosome 10 (PTEN) loss sensitizes tumors to the inhibition of mammalian target of rapamycin (mTOR), conducted a proof-of-concept Phase I neoadjuvant trial of rapamycin in patients with recurrent glioblastoma, whose tumors lacked expression of the tumor suppressor PTEN.There exists well-funded development trajectory from cancer applications.
Extrapolating from mice
Mice are excellent for testing effects. For cellular products assuming identical effects, the effects can be scaled up by constancy of per kg. weight, hence by raw weight in pre-human testing and estimating effects, to closer biomodel like primates. In USA, 10% is used as threshold of damage, meaning that 10% of mice damage is considered to be the safe upper limit by weight, So 10,000 mg safe limit for mice translates to 1000 mg limit for human of average weight. In that sense Niagen is very safe at all therapeutic levels. However +ve results may require scaling up of equivalent levels too.
Human trials are greatly effected if the goal of test chemical is to activate another. The g\oal of niagen or niacinamide or others is nad+, itself an upgradable product in nadh-nad+ energy cycle. One can measure effectiveness of precursors by measuring nad+, doable by standard assays. Done so, one finds vrious forms of coQ10, mitoq and niagen have different effects.
Extrapolating from customers
Niagen, mitoq and coQ10 have been on market for years. Any one can draw conclusions from published reactions and do their own study. Unlike research or manufacturer-studies, they can be ethically tailored for consumers. But fraud is easy, prevalent, profitable, even sound studies are subtly tainted (conflict of interest). A reliable study is aq meaningless concept, better is xyz-study, where xyz variew. Some top problems are -
fake feedback - retailer or manufacturer instigation
adverse selection - selection of stories more attractive, may be consumer or retailer driven
typing incompleteness only relevant to a thesis, may be psychological
semantic incompleteness
etc
Retailer has some interest in ensuring error freedoms. My own bias is ignoreation of small sample of stars, ignore reviews unless lot of them from certified buyers. ignore even star from 1 to 5 etc. The feedback is crucial new development for everything from story reactions, voting, products, quality measurement, including all of IoT! I have great fresh application of my earth-unique unabusable identity based encryption fiber.
Extrapolation by complimentary medicine
Extrapolating from customers
Niagen, mitoq and coQ10 have been on market for years. Any one can draw conclusions from published reactions and do their own study. Unlike research or manufacturer-studies, they can be ethically tailored for consumers. But fraud is easy, prevalent, profitable, even sound studies are subtly tainted (conflict of interest). A reliable study is aq meaningless concept, better is xyz-study, where xyz variew. Some top problems are -
fake feedback - retailer or manufacturer instigation
adverse selection - selection of stories more attractive, may be consumer or retailer driven
typing incompleteness only relevant to a thesis, may be psychological
semantic incompleteness
etc
Retailer has some interest in ensuring error freedoms. My own bias is ignoreation of small sample of stars, ignore reviews unless lot of them from certified buyers. ignore even star from 1 to 5 etc. The feedback is crucial new development for everything from story reactions, voting, products, quality measurement, including all of IoT! I have great fresh application of my earth-unique unabusable identity based encryption fiber.
Extrapolation by complimentary medicine
For now, I am the only practitioner. Key principles identified are
1. For every acute sickness, only traditional doctors make sense.
2. Comed doctors will not prescribe any drugs to be solely prescribed by traditional doctors.
The complementary nature shows by limitation to supplements and non-traditional uses of other prescriptions - metformin and ECP.
3. They will work with traditional medicine, observing their contraindications but ignore deprecation.
4. The very foundation of rapid drug testing is suspect in chronic diseases, as is unsupervised long term studies.
Let us imagine that I have a FIBER shop. Age extension studies are conducted along with sales. Let us examine me (i.e. my underlings) and customers, who would be honest, since they pay! Fake feedback is controlled by mixing honest doing illegal things - should be trapped! Adverse selection is by numbering feedback before and independently. Tying to any kind of incompleteness is also eliminated by numbering. Semantic incompleteness is by feedback from committee of critics, parsed by reasoned criticism and ignored bullshit otherwise. All easy nonsense problems are FIBER-defeated, like man-in-the-middle, repeat submissions etc! In fact there is one-to-one correspondence between easy-failures in customer-based-studies and encryption-hacking!
Conclusion
I hope they consider a eloquent miser saver Computer Scientist Professor now specializing in encryption, mental TBI worth saving, given a fit ancient, then weight lifting in 90s, after conquering and crushing all physical debilitation - genetic, accidental, or environmental; in the 2050's decade singularity.
1. For every acute sickness, only traditional doctors make sense.
2. Comed doctors will not prescribe any drugs to be solely prescribed by traditional doctors.
The complementary nature shows by limitation to supplements and non-traditional uses of other prescriptions - metformin and ECP.
3. They will work with traditional medicine, observing their contraindications but ignore deprecation.
4. The very foundation of rapid drug testing is suspect in chronic diseases, as is unsupervised long term studies.
Let us imagine that I have a FIBER shop. Age extension studies are conducted along with sales. Let us examine me (i.e. my underlings) and customers, who would be honest, since they pay! Fake feedback is controlled by mixing honest doing illegal things - should be trapped! Adverse selection is by numbering feedback before and independently. Tying to any kind of incompleteness is also eliminated by numbering. Semantic incompleteness is by feedback from committee of critics, parsed by reasoned criticism and ignored bullshit otherwise. All easy nonsense problems are FIBER-defeated, like man-in-the-middle, repeat submissions etc! In fact there is one-to-one correspondence between easy-failures in customer-based-studies and encryption-hacking!
Conclusion
I hope they consider a eloquent miser saver Computer Scientist Professor now specializing in encryption, mental TBI worth saving, given a fit ancient, then weight lifting in 90s, after conquering and crushing all physical debilitation - genetic, accidental, or environmental; in the 2050's decade singularity.
